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24  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ODBB_HUMAN (P21953)

Summary

This is the summary of UniProt entry ODBB_HUMAN (P21953).

Description: 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial EC=1.2.4.4
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 392 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 16
low_complexity n/a 1 18
disorder n/a 51 53
disorder n/a 56 61
disorder n/a 67 68
Pfam Transket_pyr 69 247
low_complexity n/a 127 144
Pfam Transketolase_C 261 382

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P21953. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAVVAAAAGW LLRLRAAGAE GHWRRLPGAG LARGFLHPAA TVEDAAQRRQ
50
51
VAHFTFQPDP EPREYGQTQK MNLFQSVTSA LDNSLAKDPT AVIFGEDVAF
100
101
GGVFRCTVGL RDKYGKDRVF NTPLCEQGIV GFGIGIAVTG ATAIAEIQFA
150
151
DYIFPAFDQI VNEAAKYRYR SGDLFNCGSL TIRSPWGCVG HGALYHSQSP
200
201
EAFFAHCPGI KVVIPRSPFQ AKGLLLSCIE DKNPCIFFEP KILYRAAAEE
250
251
VPIEPYNIPL SQAEVIQEGS DVTLVAWGTQ VHVIREVASM AKEKLGVSCE
300
301
VIDLRTIIPW DVDTICKSVI KTGRLLISHE APLTGGFASE ISSTVQEECF
350
351
LNLEAPISRV CGYDTPFPHI FEPFYIPDKW KCYDALRKMI NY        
392
 

Show the unformatted sequence.

Checksums:
CRC64:D78097834D063BB7
MD5:ed027606ec39c4899c97218c974a7374

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Transket_pyr 69 - 247 1DTW B 19 - 197 Jmol OpenAstexViewer
1OLS B 19 - 197 Jmol OpenAstexViewer
1OLU B 19 - 197 Jmol OpenAstexViewer
1OLX B 19 - 197 Jmol OpenAstexViewer
1U5B B 19 - 197 Jmol OpenAstexViewer
1V11 B 19 - 197 Jmol OpenAstexViewer
1V16 B 19 - 197 Jmol OpenAstexViewer
1V1M B 19 - 197 Jmol OpenAstexViewer
1V1R B 19 - 197 Jmol OpenAstexViewer
1WCI B 19 - 197 Jmol OpenAstexViewer
1X7W B 19 - 197 Jmol OpenAstexViewer
1X7X B 19 - 197 Jmol OpenAstexViewer
1X7Y B 19 - 197 Jmol OpenAstexViewer
1X7Z B 19 - 197 Jmol OpenAstexViewer
1X80 B 19 - 197 Jmol OpenAstexViewer
2BEU B 19 - 197 Jmol OpenAstexViewer
2BEV B 19 - 197 Jmol OpenAstexViewer
2BEW B 19 - 197 Jmol OpenAstexViewer
2BFB B 19 - 197 Jmol OpenAstexViewer
2BFC B 19 - 197 Jmol OpenAstexViewer
2BFD B 19 - 197 Jmol OpenAstexViewer
2BFE B 19 - 197 Jmol OpenAstexViewer
2BFF B 19 - 197 Jmol OpenAstexViewer
2J9F B 19 - 197 Jmol OpenAstexViewer
D 19 - 197 Jmol OpenAstexViewer
Transketolase_C 261 - 382 1DTW B 211 - 332 Jmol OpenAstexViewer
1OLS B 211 - 332 Jmol OpenAstexViewer
1OLU B 211 - 332 Jmol OpenAstexViewer
1OLX B 211 - 332 Jmol OpenAstexViewer
1U5B B 211 - 332 Jmol OpenAstexViewer
1V11 B 211 - 332 Jmol OpenAstexViewer
1V16 B 211 - 332 Jmol OpenAstexViewer
1V1M B 211 - 332 Jmol OpenAstexViewer
1V1R B 211 - 332 Jmol OpenAstexViewer
1WCI B 211 - 332 Jmol OpenAstexViewer
1X7W B 211 - 332 Jmol OpenAstexViewer
1X7X B 211 - 332 Jmol OpenAstexViewer
1X7Y B 211 - 332 Jmol OpenAstexViewer
1X7Z B 211 - 332 Jmol OpenAstexViewer
1X80 B 211 - 332 Jmol OpenAstexViewer
2BEU B 211 - 332 Jmol OpenAstexViewer
2BEV B 211 - 332 Jmol OpenAstexViewer
2BEW B 211 - 332 Jmol OpenAstexViewer
2BFB B 211 - 332 Jmol OpenAstexViewer
2BFC B 211 - 332 Jmol OpenAstexViewer
2BFD B 211 - 332 Jmol OpenAstexViewer
2BFE B 211 - 332 Jmol OpenAstexViewer
2BFF B 211 - 332 Jmol OpenAstexViewer
2J9F B 211 - 332 Jmol OpenAstexViewer
D 211 - 332 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.