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14  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CADH3_HUMAN (P22223)

Summary

This is the summary of UniProt entry CADH3_HUMAN (P22223).

Description: Cadherin-3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 829 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 23
low_complexity n/a 1 13
disorder n/a 38 39
disorder n/a 41 43
disorder n/a 49 54
disorder n/a 66 84
disorder n/a 86 88
Pfam Cadherin 112 206
disorder n/a 115 116
disorder n/a 121 131
disorder n/a 142 146
disorder n/a 153 156
disorder n/a 199 203
disorder n/a 206 208
disorder n/a 215 217
Pfam Cadherin 220 319
disorder n/a 232 234
disorder n/a 266 270
disorder n/a 282 283
disorder n/a 293 303
disorder n/a 312 315
disorder n/a 327 342
Pfam Cadherin 333 432
disorder n/a 344 350
disorder n/a 352 354
disorder n/a 375 386
disorder n/a 388 394
disorder n/a 440 441
Pfam Cadherin 445 539
disorder n/a 445 448
disorder n/a 457 466
disorder n/a 471 474
disorder n/a 489 492
disorder n/a 494 501
disorder n/a 520 522
low_complexity n/a 527 537
disorder n/a 531 537
disorder n/a 539 541
disorder n/a 549 555
disorder n/a 576 578
transmembrane n/a 655 677
low_complexity n/a 656 676
Pfam Cadherin_C 678 826
disorder n/a 699 703
low_complexity n/a 701 708
disorder n/a 710 717
disorder n/a 740 746
disorder n/a 773 779
low_complexity n/a 783 804
disorder n/a 790 800
low_complexity n/a 800 807
disorder n/a 803 804
disorder n/a 827 829

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P22223. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGLPRGPLAS LLLLQVCWLQ CAASEPCRAV FREAEVTLEA GGAEQEPGQA
50
51
LGKVFMGCPG QEPALFSTDN DDFTVRNGET VQERRSLKER NPLKIFPSKR
100
101
ILRRHKRDWV VAPISVPENG KGPFPQRLNQ LKSNKDRDTK IFYSITGPGA
150
151
DSPPEGVFAV EKETGWLLLN KPLDREEIAK YELFGHAVSE NGASVEDPMN
200
201
ISIIVTDQND HKPKFTQDTF RGSVLEGVLP GTSVMQVTAT DEDDAIYTYN
250
251
GVVAYSIHSQ EPKDPHDLMF TIHRSTGTIS VISSGLDREK VPEYTLTIQA
300
301
TDMDGDGSTT TAVAVVEILD ANDNAPMFDP QKYEAHVPEN AVGHEVQRLT
350
351
VTDLDAPNSP AWRATYLIMG GDDGDHFTIT THPESNQGIL TTRKGLDFEA
400
401
KNQHTLYVEV TNEAPFVLKL PTSTATIVVH VEDVNEAPVF VPPSKVVEVQ
450
451
EGIPTGEPVC VYTAEDPDKE NQKISYRILR DPAGWLAMDP DSGQVTAVGT
500
501
LDREDEQFVR NNIYEVMVLA MDNGSPPTTG TGTLLLTLID VNDHGPVPEP
550
551
RQITICNQSP VRQVLNITDK DLSPHTSPFQ AQLTDDSDIY WTAEVNEEGD
600
601
TVVLSLKKFL KQDTYDVHLS LSDHGNKEQL TVIRATVCDC HGHVETCPGP
650
651
WKGGFILPVL GAVLALLFLL LVLLLLVRKK RKIKEPLLLP EDDTRDNVFY
700
701
YGEEGGGEED QDYDITQLHR GLEARPEVVL RNDVAPTIIP TPMYRPRPAN
750
751
PDEIGNFIIE NLKAANTDPT APPYDTLLVF DYEGSGSDAA SLSSLTSSAS
800
801
DQDQDYDYLN EWGSRFKKLA DMYGGGEDD                       
829
 

Show the unformatted sequence.

Checksums:
CRC64:7C03C8536CD98C7B
MD5:413e22a0ff79335668459321ce8ffa4a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Cadherin 112 - 206 4OY9 A 5 - 99 Jmol OpenAstexViewer
4ZML A 5 - 99 Jmol OpenAstexViewer
4ZMN A 5 - 99 Jmol OpenAstexViewer
4ZMO A 5 - 99 Jmol OpenAstexViewer
4ZMP A 5 - 99 Jmol OpenAstexViewer
4ZMQ A 5 - 99 Jmol OpenAstexViewer
B 5 - 99 Jmol OpenAstexViewer
4ZMT A 5 - 99 Jmol OpenAstexViewer
B 5 - 99 Jmol OpenAstexViewer
C 5 - 99 Jmol OpenAstexViewer
D 5 - 99 Jmol OpenAstexViewer
E 5 - 99 Jmol OpenAstexViewer
F 5 - 99 Jmol OpenAstexViewer
4ZMV A 5 - 99 Jmol OpenAstexViewer
B 5 - 99 Jmol OpenAstexViewer
4ZMW A 5 - 99 Jmol OpenAstexViewer
B 5 - 99 Jmol OpenAstexViewer
4ZMX A 5 - 99 Jmol OpenAstexViewer
B 5 - 99 Jmol OpenAstexViewer
4ZMY A 5 - 99 Jmol OpenAstexViewer
4ZMZ A 5 - 99 Jmol OpenAstexViewer
5JYL A 5 - 99 Jmol OpenAstexViewer
C 5 - 99 Jmol OpenAstexViewer
5JYM A 5 - 99 Jmol OpenAstexViewer
C 5 - 99 Jmol OpenAstexViewer
220 - 316 4ZMT F 113 - 209 Jmol OpenAstexViewer
220 - 319 4OY9 A 113 - 212 Jmol OpenAstexViewer
4ZML A 113 - 212 Jmol OpenAstexViewer
4ZMN A 113 - 212 Jmol OpenAstexViewer
4ZMO A 113 - 212 Jmol OpenAstexViewer
4ZMP A 113 - 212 Jmol OpenAstexViewer
4ZMQ A 113 - 212 Jmol OpenAstexViewer
B 113 - 212 Jmol OpenAstexViewer
4ZMT A 113 - 212 Jmol OpenAstexViewer
B 113 - 212 Jmol OpenAstexViewer
C 113 - 212 Jmol OpenAstexViewer
D 113 - 212 Jmol OpenAstexViewer
E 113 - 212 Jmol OpenAstexViewer
4ZMV A 113 - 212 Jmol OpenAstexViewer
B 113 - 212 Jmol OpenAstexViewer
4ZMW A 113 - 212 Jmol OpenAstexViewer
B 113 - 212 Jmol OpenAstexViewer
4ZMX A 113 - 212 Jmol OpenAstexViewer
B 113 - 212 Jmol OpenAstexViewer
4ZMY A 113 - 212 Jmol OpenAstexViewer
4ZMZ A 113 - 212 Jmol OpenAstexViewer
5JYM A 113 - 212 Jmol OpenAstexViewer
C 113 - 212 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.