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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FGFR3_HUMAN (P22607)

Summary

This is the summary of UniProt entry FGFR3_HUMAN (P22607).

Description: Fibroblast growth factor receptor 3 EC=2.7.10.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 806 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 22
low_complexity n/a 1 19
disorder n/a 28 77
low_complexity n/a 61 70
disorder n/a 92 95
disorder n/a 100 101
disorder n/a 124 153
low_complexity n/a 131 148
Pfam I-set 160 245
disorder n/a 187 189
Pfam Ig_3 252 343
low_complexity n/a 353 368
Pfam FGFR3_TM 369 399
transmembrane n/a 372 396
Pfam Pkinase_Tyr 472 748
disorder n/a 765 806
low_complexity n/a 770 786
low_complexity n/a 794 803

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P22607. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGAPACALAL CVAVAIVAGA SSESLGTEQR VVGRAAEVPG PEPGQQEQLV
50
51
FGSGDAVELS CPPPGGGPMG PTVWVKDGTG LVPSERVLVG PQRLQVLNAS
100
101
HEDSGAYSCR QRLTQRVLCH FSVRVTDAPS SGDDEDGEDE AEDTGVDTGA
150
151
PYWTRPERMD KKLLAVPAAN TVRFRCPAAG NPTPSISWLK NGREFRGEHR
200
201
IGGIKLRHQQ WSLVMESVVP SDRGNYTCVV ENKFGSIRQT YTLDVLERSP
250
251
HRPILQAGLP ANQTAVLGSD VEFHCKVYSD AQPHIQWLKH VEVNGSKVGP
300
301
DGTPYVTVLK TAGANTTDKE LEVLSLHNVT FEDAGEYTCL AGNSIGFSHH
350
351
SAWLVVLPAE EELVEADEAG SVYAGILSYG VGFFLFILVV AAVTLCRLRS
400
401
PPKKGLGSPT VHKISRFPLK RQVSLESNAS MSSNTPLVRI ARLSSGEGPT
450
451
LANVSELELP ADPKWELSRA RLTLGKPLGE GCFGQVVMAE AIGIDKDRAA
500
501
KPVTVAVKML KDDATDKDLS DLVSEMEMMK MIGKHKNIIN LLGACTQGGP
550
551
LYVLVEYAAK GNLREFLRAR RPPGLDYSFD TCKPPEEQLT FKDLVSCAYQ
600
601
VARGMEYLAS QKCIHRDLAA RNVLVTEDNV MKIADFGLAR DVHNLDYYKK
650
651
TTNGRLPVKW MAPEALFDRV YTHQSDVWSF GVLLWEIFTL GGSPYPGIPV
700
701
EELFKLLKEG HRMDKPANCT HDLYMIMREC WHAAPSQRPT FKQLVEDLDR
750
751
VLTVTSTDEY LDLSAPFEQY SPGGQDTPSS SSSGDDSVFA HDLLPPAPPS
800
801
SGGSRT                                                
806
 

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Checksums:
CRC64:BC5EA75EA46F447E
MD5:632616f7ccb30252cd89afba2784beec

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
FGFR3_TM 369 - 399 2LZL A 369 - 399 Jmol OpenAstexViewer
B 369 - 399 Jmol OpenAstexViewer
I-set 160 - 245 1RY7 B 160 - 245 Jmol OpenAstexViewer
Ig_3 252 - 343 1RY7 B 252 - 343 Jmol OpenAstexViewer
Pkinase_Tyr 472 - 748 4K33 A 472 - 748 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.