Summary
This is the summary of UniProt entry MMP8_HUMAN (P22894).
Description: | Neutrophil collagenase EC=3.4.24.34 |
Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
Length: | 467 amino acids |
Reference Proteome: |
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Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
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Source | Domain | Start | End |
---|---|---|---|
sig_p | n/a | 1 | 20 |
low_complexity | n/a | 3 | 12 |
Pfam | PG_binding_1 | 26 | 86 |
disorder | n/a | 83 | 88 |
disorder | n/a | 95 | 96 |
disorder | n/a | 98 | 99 |
Pfam | Peptidase_M10 | 107 | 262 |
disorder | n/a | 174 | 180 |
disorder | n/a | 193 | 197 |
disorder | n/a | 267 | 277 |
Pfam | Hemopexin | 285 | 327 |
Pfam | Hemopexin | 329 | 372 |
Pfam | Hemopexin | 377 | 422 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P22894. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
Sequence: | 1
MFSLKTLPFL LLLHVQISKA FPVSSKEKNT KTVQDYLEKF YQLPSNQYQS
50 51
TRKNGTNVIV EKLKEMQRFF GLNVTGKPNE ETLDMMKKPR CGVPDSGGFM
100 101
LTPGNPKWER TNLTYRIRNY TPQLSEAEVE RAIKDAFELW SVASPLIFTR
150 151
ISQGEADINI AFYQRDHGDN SPFDGPNGIL AHAFQPGQGI GGDAHFDAEE
200 201
TWTNTSANYN LFLVAAHEFG HSLGLAHSSD PGALMYPNYA FRETSNYSLP
250 251
QDDIDGIQAI YGLSSNPIQP TGPSTPKPCD PSLTFDAITT LRGEILFFKD
300 301
RYFWRRHPQL QRVEMNFISL FWPSLPTGIQ AAYEDFDRDL IFLFKGNQYW
350 351
ALSGYDILQG YPKDISNYGF PSSVQAIDAA VFYRSKTYFF VNDQFWRYDN
400 401
QRQFMEPGYP KSISGAFPGI ESKVDAVFQQ EHFFHVFSGP RYYAFDLIAQ
450 451
RVTRVARGNK WLNCRYG
467
Show the unformatted sequence. |
Checksums: |
CRC64:4D4602A53AD7F8BC
MD5:9b1fa90a47b5a5572926013b922b7c5f
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.