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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SFPQ_HUMAN (P23246)

Summary

This is the summary of UniProt entry SFPQ_HUMAN (P23246).

Description: Splicing factor, proline- and glutamine-rich
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 707 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 289
low_complexity n/a 1 32
low_complexity n/a 45 103
low_complexity n/a 113 178
low_complexity n/a 172 228
low_complexity n/a 226 249
low_complexity n/a 242 265
disorder n/a 295 296
Pfam RRM_1 299 363
Pfam RRM_1 373 440
disorder n/a 415 416
Pfam NOPS 444 495
disorder n/a 447 483
disorder n/a 497 707
coiled_coil n/a 498 529
coiled_coil n/a 532 595
low_complexity n/a 533 551
low_complexity n/a 561 594
low_complexity n/a 602 621
low_complexity n/a 624 646
low_complexity n/a 667 687
low_complexity n/a 689 699

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P23246. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSRDRFRSRG GGGGGFHRRG GGGGRGGLHD FRSPPPGMGL NQNRGPMGPG
50
51
PGQSGPKPPI PPPPPHQQQQ QPPPQQPPPQ QPPPHQPPPH PQPHQQQQPP
100
101
PPPQDSSKPV VAQGPGPAPG VGSAPPASSS APPATPPTSG APPGSGPGPT
150
151
PTPPPAVTSA PPGAPPPTPP SSGVPTTPPQ AGGPPPPPAA VPGPGPGPKQ
200
201
GPGPGGPKGG KMPGGPKPGG GPGLSTPGGH PKPPHRGGGE PRGGRQHHPP
250
251
YHQQHHQGPP PGGPGGRSEE KISDSEGFKA NLSLLRRPGE KTYTQRCRLF
300
301
VGNLPADITE DEFKRLFAKY GEPGEVFINK GKGFGFIKLE SRALAEIAKA
350
351
ELDDTPMRGR QLRVRFATHA AALSVRNLSP YVSNELLEEA FSQFGPIERA
400
401
VVIVDDRGRS TGKGIVEFAS KPAARKAFER CSEGVFLLTT TPRPVIVEPL
450
451
EQLDDEDGLP EKLAQKNPMY QKERETPPRF AQHGTFEYEY SQRWKSLDEM
500
501
EKQQREQVEK NMKDAKDKLE SEMEDAYHEH QANLLRQDLM RRQEELRRME
550
551
ELHNQEMQKR KEMQLRQEEE RRRREEEMMI RQREMEEQMR RQREESYSRM
600
601
GYMDPRERDM RMGGGGAMNM GDPYGSGGQK FPPLGGGGGI GYEANPGVPP
650
651
ATMSGSMMGS DMRTERFGQG GAGPVGGQGP RGMGPGTPAG YGRGREEYEG
700
701
PNKKPRF                                               
707
 

Show the unformatted sequence.

Checksums:
CRC64:6D8D5EA95E235847
MD5:6cccf6a607fbf8cad29b6aa81963d8f6

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
NOPS 444 - 495 4WII A 444 - 495 Jmol OpenAstexViewer
B 444 - 495 Jmol OpenAstexViewer
4WIJ A 444 - 495 Jmol OpenAstexViewer
B 444 - 495 Jmol OpenAstexViewer
4WIK A 444 - 495 Jmol OpenAstexViewer
B 444 - 495 Jmol OpenAstexViewer
5WPA A 444 - 495 Jmol OpenAstexViewer
6NCQ A 444 - 495 Jmol OpenAstexViewer
RRM_1 299 - 363 4WII A 299 - 363 Jmol OpenAstexViewer
B 299 - 363 Jmol OpenAstexViewer
4WIJ A 299 - 363 Jmol OpenAstexViewer
B 299 - 363 Jmol OpenAstexViewer
5WPA A 299 - 363 Jmol OpenAstexViewer
6NCQ A 299 - 363 Jmol OpenAstexViewer
373 - 440 4WII A 373 - 440 Jmol OpenAstexViewer
B 373 - 440 Jmol OpenAstexViewer
4WIJ A 373 - 440 Jmol OpenAstexViewer
B 373 - 440 Jmol OpenAstexViewer
4WIK A 373 - 440 Jmol OpenAstexViewer
B 373 - 440 Jmol OpenAstexViewer
5WPA A 373 - 440 Jmol OpenAstexViewer
6NCQ A 373 - 440 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.