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7  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TKT1_YEAST (P23254)

Summary

This is the summary of UniProt entry TKT1_YEAST (P23254).

Description: Transketolase 1 EC=2.2.1.1
Source organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (NCBI taxonomy ID 559292)
Length: 680 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam Transketolase_N 7 339
disorder n/a 29 32
disorder n/a 98 99
disorder n/a 104 111
Pfam Transket_pyr 354 533
disorder n/a 394 395
disorder n/a 475 478
disorder n/a 483 484
disorder n/a 510 511
Pfam Transketolase_C 546 656

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P23254. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTQFTDIDKL AVSTIRILAV DTVSKANSGH PGAPLGMAPA AHVLWSQMRM
50
51
NPTNPDWINR DRFVLSNGHA VALLYSMLHL TGYDLSIEDL KQFRQLGSRT
100
101
PGHPEFELPG VEVTTGPLGQ GISNAVGMAM AQANLAATYN KPGFTLSDNY
150
151
TYVFLGDGCL QEGISSEASS LAGHLKLGNL IAIYDDNKIT IDGATSISFD
200
201
EDVAKRYEAY GWEVLYVENG NEDLAGIAKA IAQAKLSKDK PTLIKMTTTI
250
251
GYGSLHAGSH SVHGAPLKAD DVKQLKSKFG FNPDKSFVVP QEVYDHYQKT
300
301
ILKPGVEANN KWNKLFSEYQ KKFPELGAEL ARRLSGQLPA NWESKLPTYT
350
351
AKDSAVATRK LSETVLEDVY NQLPELIGGS ADLTPSNLTR WKEALDFQPP
400
401
SSGSGNYSGR YIRYGIREHA MGAIMNGISA FGANYKPYGG TFLNFVSYAA
450
451
GAVRLSALSG HPVIWVATHD SIGVGEDGPT HQPIETLAHF RSLPNIQVWR
500
501
PADGNEVSAA YKNSLESKHT PSIIALSRQN LPQLEGSSIE SASKGGYVLQ
550
551
DVANPDIILV ATGSEVSLSV EAAKTLAAKN IKARVVSLPD FFTFDKQPLE
600
601
YRLSVLPDNV PIMSVEVLAT TCWGKYAHQS FGIDRFGASG KAPEVFKFFG
650
651
FTPEGVAERA QKTIAFYKGD KLISPLKKAF                      
680
 

Show the unformatted sequence.

Checksums:
CRC64:40225EAA23A63835
MD5:878319897bc66dca21388009765cade3

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Transket_pyr 354 - 533 1AY0 A 354 - 533 Show 3D Structure View in InterPro
B 354 - 533 Show 3D Structure View in InterPro
1GPU A 354 - 533 Show 3D Structure View in InterPro
B 354 - 533 Show 3D Structure View in InterPro
1NGS A 354 - 533 Show 3D Structure View in InterPro
B 354 - 533 Show 3D Structure View in InterPro
1TKA A 354 - 533 Show 3D Structure View in InterPro
B 354 - 533 Show 3D Structure View in InterPro
1TKB A 354 - 533 Show 3D Structure View in InterPro
B 354 - 533 Show 3D Structure View in InterPro
1TKC A 354 - 533 Show 3D Structure View in InterPro
B 354 - 533 Show 3D Structure View in InterPro
1TRK A 354 - 533 Show 3D Structure View in InterPro
B 354 - 533 Show 3D Structure View in InterPro
Transketolase_C 546 - 656 1AY0 A 546 - 656 Show 3D Structure View in InterPro
B 546 - 656 Show 3D Structure View in InterPro
1GPU A 546 - 656 Show 3D Structure View in InterPro
B 546 - 656 Show 3D Structure View in InterPro
1NGS A 546 - 656 Show 3D Structure View in InterPro
B 546 - 656 Show 3D Structure View in InterPro
1TKA A 546 - 656 Show 3D Structure View in InterPro
B 546 - 656 Show 3D Structure View in InterPro
1TKB A 546 - 656 Show 3D Structure View in InterPro
B 546 - 656 Show 3D Structure View in InterPro
1TKC A 546 - 656 Show 3D Structure View in InterPro
B 546 - 656 Show 3D Structure View in InterPro
1TRK A 546 - 656 Show 3D Structure View in InterPro
B 546 - 656 Show 3D Structure View in InterPro
Transketolase_N 7 - 339 1AY0 A 7 - 339 Show 3D Structure View in InterPro
B 7 - 339 Show 3D Structure View in InterPro
1GPU A 7 - 339 Show 3D Structure View in InterPro
B 7 - 339 Show 3D Structure View in InterPro
1NGS A 7 - 339 Show 3D Structure View in InterPro
B 7 - 339 Show 3D Structure View in InterPro
1TKA A 7 - 339 Show 3D Structure View in InterPro
B 7 - 339 Show 3D Structure View in InterPro
1TKB A 7 - 339 Show 3D Structure View in InterPro
B 7 - 339 Show 3D Structure View in InterPro
1TKC A 7 - 339 Show 3D Structure View in InterPro
B 7 - 339 Show 3D Structure View in InterPro
1TRK A 7 - 339 Show 3D Structure View in InterPro
B 7 - 339 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;