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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: GLRA1_HUMAN (P23415)

Summary

This is the summary of UniProt entry GLRA1_HUMAN (P23415).

Description: Glycine receptor subunit alpha-1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 457 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
low_complexity n/a 20 34
Pfam Neur_chan_LBD 38 248
low_complexity n/a 106 119
transmembrane n/a 250 272
Pfam Neur_chan_memb 255 405
transmembrane n/a 313 336
low_complexity n/a 338 352
disorder n/a 391 411
low_complexity n/a 392 405
transmembrane n/a 429 449

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P23415. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MYSFNTLRLY LWETIVFFSL AASKEAEAAR SAPKPMSPSD FLDKLMGRTS
50
51
GYDARIRPNF KGPPVNVSCN IFINSFGSIA ETTMDYRVNI FLRQQWNDPR
100
101
LAYNEYPDDS LDLDPSMLDS IWKPDLFFAN EKGAHFHEIT TDNKLLRISR
150
151
NGNVLYSIRI TLTLACPMDL KNFPMDVQTC IMQLESFGYT MNDLIFEWQE
200
201
QGAVQVADGL TLPQFILKEE KDLRYCTKHY NTGKFTCIEA RFHLERQMGY
250
251
YLIQMYIPSL LIVILSWISF WINMDAAPAR VGLGITTVLT MTTQSSGSRA
300
301
SLPKVSYVKA IDIWMAVCLL FVFSALLEYA AVNFVSRQHK ELLRFRRKRR
350
351
HHKSPMLNLF QEDEAGEGRF NFSAYGMGPA CLQAKDGISV KGANNSNTTN
400
401
PPPAPSKSPE EMRKLFIQRA KKIDKISRIG FPMAFLIFNM FYWIIYKIVR
450
451
REDVHNQ                                               
457
 

Show the unformatted sequence.

Checksums:
CRC64:5ED80AF62B06A3AA
MD5:c8c0bf97e3303bf27d3d61a245eda025

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Neur_chan_LBD 173 - 248 4X5T A 119 - 220 Jmol OpenAstexViewer
B 119 - 220 Jmol OpenAstexViewer
C 119 - 220 Jmol OpenAstexViewer
D 119 - 220 Jmol OpenAstexViewer
E 119 - 220 Jmol OpenAstexViewer
244 - 248 2M6B A 216 - 220 Jmol OpenAstexViewer
2M6I A 216 - 220 Jmol OpenAstexViewer
B 216 - 220 Jmol OpenAstexViewer
C 216 - 220 Jmol OpenAstexViewer
D 216 - 220 Jmol OpenAstexViewer
E 216 - 220 Jmol OpenAstexViewer
Neur_chan_memb 255 - 338 4X5T A 227 - 310 Jmol OpenAstexViewer
B 227 - 310 Jmol OpenAstexViewer
C 227 - 310 Jmol OpenAstexViewer
D 227 - 310 Jmol OpenAstexViewer
E 227 - 310 Jmol OpenAstexViewer
255 - 387 2M6B A 227 - 317 Jmol OpenAstexViewer
2M6I A 227 - 317 Jmol OpenAstexViewer
B 227 - 317 Jmol OpenAstexViewer
C 227 - 317 Jmol OpenAstexViewer
D 227 - 317 Jmol OpenAstexViewer
E 227 - 317 Jmol OpenAstexViewer
277 - 304 1MOT A 249 - 276 Jmol OpenAstexViewer
278 - 337 1VRY A -2 - 57 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.