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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FSHR_HUMAN (P23945)

Summary

This is the summary of UniProt entry FSHR_HUMAN (P23945).

Description: Follicle-stimulating hormone receptor
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 695 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 17
low_complexity n/a 2 14
Pfam LRRNT 17 45
Pfam LRR_5 46 147
Pfam LRR_5 139 257
low_complexity n/a 195 212
Pfam GnHR_trans 282 349
transmembrane n/a 367 387
Pfam 7tm_1 379 626
transmembrane n/a 399 424
transmembrane n/a 444 465
transmembrane n/a 486 509
low_complexity n/a 495 508
transmembrane n/a 529 554
transmembrane n/a 575 597
transmembrane n/a 609 629
disorder n/a 665 667
disorder n/a 670 672

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P23945. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MALLLVSLLA FLSLGSGCHH RICHCSNRVF LCQESKVTEI PSDLPRNAIE
50
51
LRFVLTKLRV IQKGAFSGFG DLEKIEISQN DVLEVIEADV FSNLPKLHEI
100
101
RIEKANNLLY INPEAFQNLP NLQYLLISNT GIKHLPDVHK IHSLQKVLLD
150
151
IQDNINIHTI ERNSFVGLSF ESVILWLNKN GIQEIHNCAF NGTQLDELNL
200
201
SDNNNLEELP NDVFHGASGP VILDISRTRI HSLPSYGLEN LKKLRARSTY
250
251
NLKKLPTLEK LVALMEASLT YPSHCCAFAN WRRQISELHP ICNKSILRQE
300
301
VDYMTQARGQ RSSLAEDNES SYSRGFDMTY TEFDYDLCNE VVDVTCSPKP
350
351
DAFNPCEDIM GYNILRVLIW FISILAITGN IIVLVILTTS QYKLTVPRFL
400
401
MCNLAFADLC IGIYLLLIAS VDIHTKSQYH NYAIDWQTGA GCDAAGFFTV
450
451
FASELSVYTL TAITLERWHT ITHAMQLDCK VQLRHAASVM VMGWIFAFAA
500
501
ALFPIFGISS YMKVSICLPM DIDSPLSQLY VMSLLVLNVL AFVVICGCYI
550
551
HIYLTVRNPN IVSSSSDTRI AKRMAMLIFT DFLCMAPISF FAISASLKVP
600
601
LITVSKAKIL LVLFHPINSC ANPFLYAIFT KNFRRDFFIL LSKCGCYEMQ
650
651
AQIYRTETSS TVHNTHPRNG HCSSAPRVTN GSTYILVPLS HLAQN     
695
 

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Checksums:
CRC64:766BC421014CD5A4
MD5:a68e26905ba58a65e0870841cfd6ec44

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
GnHR_trans 282 - 349 4AY9 X 282 - 349 Show 3D Structure View in InterPro
Y 282 - 349 Show 3D Structure View in InterPro
Z 282 - 349 Show 3D Structure View in InterPro
4MQW X 282 - 349 Show 3D Structure View in InterPro
Z 282 - 349 Show 3D Structure View in InterPro
334 - 349 4MQW Y 334 - 349 Show 3D Structure View in InterPro
LRR_5 139 - 250 1XWD F 139 - 250 Show 3D Structure View in InterPro
139 - 257 1XWD C 139 - 257 Show 3D Structure View in InterPro
4AY9 X 139 - 257 Show 3D Structure View in InterPro
Y 139 - 257 Show 3D Structure View in InterPro
Z 139 - 257 Show 3D Structure View in InterPro
4MQW X 139 - 257 Show 3D Structure View in InterPro
Y 139 - 257 Show 3D Structure View in InterPro
Z 139 - 257 Show 3D Structure View in InterPro
46 - 147 1XWD C 46 - 147 Show 3D Structure View in InterPro
F 46 - 147 Show 3D Structure View in InterPro
4AY9 X 46 - 147 Show 3D Structure View in InterPro
Y 46 - 147 Show 3D Structure View in InterPro
Z 46 - 147 Show 3D Structure View in InterPro
4MQW X 46 - 147 Show 3D Structure View in InterPro
Y 46 - 147 Show 3D Structure View in InterPro
Z 46 - 147 Show 3D Structure View in InterPro
LRRNT 18 - 45 1XWD C 18 - 45 Show 3D Structure View in InterPro
F 18 - 45 Show 3D Structure View in InterPro
4AY9 X 18 - 45 Show 3D Structure View in InterPro
Y 18 - 45 Show 3D Structure View in InterPro
Z 18 - 45 Show 3D Structure View in InterPro
4MQW X 18 - 45 Show 3D Structure View in InterPro
Y 18 - 45 Show 3D Structure View in InterPro
Z 18 - 45 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;