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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CCND1_HUMAN (P24385)

Summary

This is the summary of UniProt entry CCND1_HUMAN (P24385).

Description: G1/S-specific cyclin-D1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 295 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Cyclin_N 26 153
low_complexity n/a 65 76
Pfam Cyclin_C 155 282
low_complexity n/a 202 211
coiled_coil n/a 259 279
disorder n/a 262 285
low_complexity n/a 271 279

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P24385. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEHQLLCCEV ETIRRAYPDA NLLNDRVLRA MLKAEETCAP SVSYFKCVQK
50
51
EVLPSMRKIV ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS LEPVKKSRLQ
100
101
LLGATCMFVA SKMKETIPLT AEKLCIYTDN SIRPEELLQM ELLLVNKLKW
150
151
NLAAMTPHDF IEHFLSKMPE AEENKQIIRK HAQTFVALCA TDVKFISNPP
200
201
SMVAAGSVVA AVQGLNLRSP NNFLSYYRLT RFLSRVIKCD PDCLRACQEQ
250
251
IEALLESSLR QAQQNMDPKA AEEEEEEEEE VDLACTPTDV RDVDI     
295
 

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Checksums:
CRC64:3CC00C9905F58D3A
MD5:0fc93a360e31633af786d3b2827e5437

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Cyclin_C 155 - 261 2W9F A 155 - 261 Jmol OpenAstexViewer
155 - 265 2W96 A 155 - 265 Jmol OpenAstexViewer
155 - 267 2W99 A 155 - 267 Jmol OpenAstexViewer
2W9Z A 155 - 267 Jmol OpenAstexViewer
Cyclin_N 26 - 153 2W96 A 26 - 153 Jmol OpenAstexViewer
2W99 A 26 - 153 Jmol OpenAstexViewer
2W9F A 26 - 153 Jmol OpenAstexViewer
2W9Z A 26 - 153 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.