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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TENA_HUMAN (P24821)

Summary

This is the summary of UniProt entry TENA_HUMAN (P24821).

Description: Tenascin
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 2201 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 22
low_complexity n/a 6 18
disorder n/a 36 37
disorder n/a 40 41
disorder n/a 71 92
coiled_coil n/a 119 139
low_complexity n/a 120 137
Pfam EGF_Tenascin 189 217
Pfam EGF_2 221 247
Pfam EGF_Tenascin 251 280
Pfam EGF_Tenascin 283 311
Pfam EGF_Tenascin 345 373
Pfam EGF_2 377 403
Pfam EGF_Tenascin 407 435
Pfam EGF_Tenascin 438 466
Pfam EGF_2 470 496
Pfam EGF_Tenascin 500 528
Pfam EGF_2 532 558
Pfam EGF_Tenascin 562 590
Pfam EGF_Tenascin 593 621
Pfam fn3 624 701
low_complexity n/a 629 638
disorder n/a 666 667
Pfam fn3 713 794
disorder n/a 755 769
disorder n/a 795 802
Pfam fn3 804 884
disorder n/a 806 809
disorder n/a 844 862
disorder n/a 871 878
disorder n/a 880 901
Pfam fn3 894 977
disorder n/a 904 907
disorder n/a 934 956
disorder n/a 963 970
disorder n/a 972 993
Pfam fn3 986 1065
disorder n/a 1051 1055
disorder n/a 1060 1075
Pfam fn3 1074 1154
disorder n/a 1159 1160
Pfam fn3 1166 1248
disorder n/a 1209 1213
disorder n/a 1249 1250
disorder n/a 1253 1255
Pfam fn3 1257 1337
disorder n/a 1287 1290
disorder n/a 1299 1304
disorder n/a 1326 1327
disorder n/a 1337 1338
Pfam fn3 1348 1427
Pfam fn3 1439 1511
disorder n/a 1440 1442
Pfam fn3 1530 1610
disorder n/a 1610 1615
Pfam fn3 1621 1701
disorder n/a 1664 1668
disorder n/a 1704 1705
Pfam fn3 1711 1790
disorder n/a 1753 1756
disorder n/a 1792 1794
Pfam fn3 1800 1877
disorder n/a 1879 1883
Pfam fn3 1888 1964
disorder n/a 1890 1892
disorder n/a 1899 1900
Pfam Fibrinogen_C 1980 2189
disorder n/a 2195 2200

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P24821. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGAMTQLLAG VFLAFLALAT EGGVLKKVIR HKRQSGVNAT LPEENQPVVF
50
51
NHVYNIKLPV GSQCSVDLES ASGEKDLAPP SEPSESFQEH TVDGENQIVF
100
101
THRINIPRRA CGCAAAPDVK ELLSRLEELE NLVSSLREQC TAGAGCCLQP
150
151
ATGRLDTRPF CSGRGNFSTE GCGCVCEPGW KGPNCSEPEC PGNCHLRGRC
200
201
IDGQCICDDG FTGEDCSQLA CPSDCNDQGK CVNGVCICFE GYAGADCSRE
250
251
ICPVPCSEEH GTCVDGLCVC HDGFAGDDCN KPLCLNNCYN RGRCVENECV
300
301
CDEGFTGEDC SELICPNDCF DRGRCINGTC YCEEGFTGED CGKPTCPHAC
350
351
HTQGRCEEGQ CVCDEGFAGV DCSEKRCPAD CHNRGRCVDG RCECDDGFTG
400
401
ADCGELKCPN GCSGHGRCVN GQCVCDEGYT GEDCSQLRCP NDCHSRGRCV
450
451
EGKCVCEQGF KGYDCSDMSC PNDCHQHGRC VNGMCVCDDG YTGEDCRDRQ
500
501
CPRDCSNRGL CVDGQCVCED GFTGPDCAEL SCPNDCHGQG RCVNGQCVCH
550
551
EGFMGKDCKE QRCPSDCHGQ GRCVDGQCIC HEGFTGLDCG QHSCPSDCNN
600
601
LGQCVSGRCI CNEGYSGEDC SEVSPPKDLV VTEVTEETVN LAWDNEMRVT
650
651
EYLVVYTPTH EGGLEMQFRV PGDQTSTIIQ ELEPGVEYFI RVFAILENKK
700
701
SIPVSARVAT YLPAPEGLKF KSIKETSVEV EWDPLDIAFE TWEIIFRNMN
750
751
KEDEGEITKS LRRPETSYRQ TGLAPGQEYE ISLHIVKNNT RGPGLKRVTT
800
801
TRLDAPSQIE VKDVTDTTAL ITWFKPLAEI DGIELTYGIK DVPGDRTTID
850
851
LTEDENQYSI GNLKPDTEYE VSLISRRGDM SSNPAKETFT TGLDAPRNLR
900
901
RVSQTDNSIT LEWRNGKAAI DSYRIKYAPI SGGDHAEVDV PKSQQATTKT
950
951
TLTGLRPGTE YGIGVSAVKE DKESNPATIN AATELDTPKD LQVSETAETS
1000
1001
LTLLWKTPLA KFDRYRLNYS LPTGQWVGVQ LPRNTTSYVL RGLEPGQEYN
1050
1051
VLLTAEKGRH KSKPARVKAS TEQAPELENL TVTEVGWDGL RLNWTAADQA
1100
1101
YEHFIIQVQE ANKVEAARNL TVPGSLRAVD IPGLKAATPY TVSIYGVIQG
1150
1151
YRTPVLSAEA STGETPNLGE VVVAEVGWDA LKLNWTAPEG AYEYFFIQVQ
1200
1201
EADTVEAAQN LTVPGGLRST DLPGLKAATH YTITIRGVTQ DFSTTPLSVE
1250
1251
VLTEEVPDMG NLTVTEVSWD ALRLNWTTPD GTYDQFTIQV QEADQVEEAH
1300
1301
NLTVPGSLRS MEIPGLRAGT PYTVTLHGEV RGHSTRPLAV EVVTEDLPQL
1350
1351
GDLAVSEVGW DGLRLNWTAA DNAYEHFVIQ VQEVNKVEAA QNLTLPGSLR
1400
1401
AVDIPGLEAA TPYRVSIYGV IRGYRTPVLS AEASTAKEPE IGNLNVSDIT
1450
1451
PESFNLSWMA TDGIFETFTI EIIDSNRLLE TVEYNISGAE RTAHISGLPP
1500
1501
STDFIVYLSG LAPSIRTKTI SATATTEALP LLENLTISDI NPYGFTVSWM
1550
1551
ASENAFDSFL VTVVDSGKLL DPQEFTLSGT QRKLELRGLI TGIGYEVMVS
1600
1601
GFTQGHQTKP LRAEIVTEAE PEVDNLLVSD ATPDGFRLSW TADEGVFDNF
1650
1651
VLKIRDTKKQ SEPLEITLLA PERTRDITGL REATEYEIEL YGISKGRRSQ
1700
1701
TVSAIATTAM GSPKEVIFSD ITENSATVSW RAPTAQVESF RITYVPITGG
1750
1751
TPSMVTVDGT KTQTRLVKLI PGVEYLVSII AMKGFEESEP VSGSFTTALD
1800
1801
GPSGLVTANI TDSEALARWQ PAIATVDSYV ISYTGEKVPE ITRTVSGNTV
1850
1851
EYALTDLEPA TEYTLRIFAE KGPQKSSTIT AKFTTDLDSP RDLTATEVQS
1900
1901
ETALLTWRPP RASVTGYLLV YESVDGTVKE VIVGPDTTSY SLADLSPSTH
1950
1951
YTAKIQALNG PLRSNMIQTI FTTIGLLYPF PKDCSQAMLN GDTTSGLYTI
2000
2001
YLNGDKAEAL EVFCDMTSDG GGWIVFLRRK NGRENFYQNW KAYAAGFGDR
2050
2051
REEFWLGLDN LNKITAQGQY ELRVDLRDHG ETAFAVYDKF SVGDAKTRYK
2100
2101
LKVEGYSGTA GDSMAYHNGR SFSTFDKDTD SAITNCALSY KGAFWYRNCH
2150
2151
RVNLMGRYGD NNHSQGVNWF HWKGHEHSIQ FAEMKLRPSN FRNLEGRRKR
2200
2201
A                                                     
2201
 

Show the unformatted sequence.

Checksums:
CRC64:B2BEF378AA6F1D85
MD5:e8427bf5a0779eca20887e59e5e98982

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
fn3 804 - 884 1TEN A 804 - 884 Jmol OpenAstexViewer
2RB8 A 804 - 884 Jmol OpenAstexViewer
2RBL A 804 - 884 Jmol OpenAstexViewer
B 804 - 884 Jmol OpenAstexViewer
M 804 - 884 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.