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25  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: APC_HUMAN (P25054)

Summary

This is the summary of UniProt entry APC_HUMAN (P25054).

Description: Adenomatous polyposis coli protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 2843 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam APC_N_CC 4 55
coiled_coil n/a 6 54
disorder n/a 17 43
disorder n/a 45 54
low_complexity n/a 93 110
disorder n/a 97 112
disorder n/a 114 122
Pfam Suppressor_APC 127 207
low_complexity n/a 133 144
coiled_coil n/a 134 168
low_complexity n/a 142 155
disorder n/a 173 174
disorder n/a 176 177
disorder n/a 179 181
disorder n/a 183 186
disorder n/a 189 195
disorder n/a 200 212
coiled_coil n/a 207 227
low_complexity n/a 212 223
disorder n/a 215 216
disorder n/a 235 307
low_complexity n/a 289 298
disorder n/a 329 340
disorder n/a 368 375
disorder n/a 384 392
Pfam APC_rep 393 466
disorder n/a 428 439
Pfam Arm 512 553
coiled_coil n/a 530 550
Pfam Arm 649 689
Pfam Arm_APC_u3 732 1019
disorder n/a 739 744
disorder n/a 746 757
disorder n/a 760 761
disorder n/a 763 764
disorder n/a 771 802
disorder n/a 806 942
low_complexity n/a 832 845
disorder n/a 948 955
disorder n/a 958 988
low_complexity n/a 958 970
disorder n/a 990 991
disorder n/a 1005 1185
Pfam APC_15aa 1020 1034
Pfam APC_u5 1036 1135
Pfam APC_15aa 1136 1150
low_complexity n/a 1142 1157
Pfam APC_15aa 1155 1169
Pfam APC_15aa 1172 1186
low_complexity n/a 1188 1206
disorder n/a 1190 1251
low_complexity n/a 1204 1214
low_complexity n/a 1211 1223
Pfam APC_r 1257 1280
low_complexity n/a 1274 1281
Pfam APC_u9 1282 1368
disorder n/a 1284 1384
low_complexity n/a 1333 1345
low_complexity n/a 1354 1365
Pfam APC_r 1371 1393
disorder n/a 1387 1389
disorder n/a 1395 1479
low_complexity n/a 1431 1449
low_complexity n/a 1468 1480
disorder n/a 1482 1497
Pfam APC_r 1486 1509
disorder n/a 1499 1508
low_complexity n/a 1500 1510
disorder n/a 1511 1568
coiled_coil n/a 1543 1563
low_complexity n/a 1556 1580
Pfam SAMP 1567 1588
disorder n/a 1574 1579
disorder n/a 1585 1639
Pfam APC_r 1637 1660
disorder n/a 1641 1645
disorder n/a 1654 1844
Pfam APC_u13 1662 1715
Pfam SAMP 1716 1737
Pfam APC_u14 1746 1839
low_complexity n/a 1752 1758
Pfam APC_r 1841 1865
disorder n/a 1848 1855
low_complexity n/a 1859 1874
disorder n/a 1866 1958
Pfam APC_u15 1867 1947
coiled_coil n/a 1871 1894
Pfam APC_r 1949 1972
disorder n/a 1965 2015
low_complexity n/a 1966 1972
low_complexity n/a 1977 1992
Pfam APC_r 2008 2030
low_complexity n/a 2024 2038
disorder n/a 2025 2026
Pfam SAMP 2031 2052
disorder n/a 2038 2039
disorder n/a 2041 2100
low_complexity n/a 2112 2129
disorder n/a 2122 2123
low_complexity n/a 2128 2145
disorder n/a 2135 2136
disorder n/a 2146 2187
low_complexity n/a 2178 2192
disorder n/a 2192 2197
disorder n/a 2199 2647
Pfam APC_basic 2223 2575
low_complexity n/a 2238 2246
low_complexity n/a 2347 2368
low_complexity n/a 2455 2476
low_complexity n/a 2568 2589
disorder n/a 2656 2843
Pfam EB1_binding 2670 2843
low_complexity n/a 2762 2773

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P25054. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE ASNMKEVLKQ
50
51
LQGSIEDEAM ASSGQIDLLE RLKELNLDSS NFPGVKLRSK MSLRSYGSRE
100
101
GSVSSRSGEC SPVPMGSFPR RGFVNGSRES TGYLEELEKE RSLLLADLDK
150
151
EEKEKDWYYA QLQNLTKRID SLPLTENFSL QTDMTRRQLE YEARQIRVAM
200
201
EEQLGTCQDM EKRAQRRIAR IQQIEKDILR IRQLLQSQAT EAERSSQNKH
250
251
ETGSHDAERQ NEGQGVGEIN MATSGNGQGS TTRMDHETAS VLSSSSTHSA
300
301
PRRLTSHLGT KVEMVYSLLS MLGTHDKDDM SRTLLAMSSS QDSCISMRQS
350
351
GCLPLLIQLL HGNDKDSVLL GNSRGSKEAR ARASAALHNI IHSQPDDKRG
400
401
RREIRVLHLL EQIRAYCETC WEWQEAHEPG MDQDKNPMPA PVEHQICPAV
450
451
CVLMKLSFDE EHRHAMNELG GLQAIAELLQ VDCEMYGLTN DHYSITLRRY
500
501
AGMALTNLTF GDVANKATLC SMKGCMRALV AQLKSESEDL QQVIASVLRN
550
551
LSWRADVNSK KTLREVGSVK ALMECALEVK KESTLKSVLS ALWNLSAHCT
600
601
ENKADICAVD GALAFLVGTL TYRSQTNTLA IIESGGGILR NVSSLIATNE
650
651
DHRQILRENN CLQTLLQHLK SHSLTIVSNA CGTLWNLSAR NPKDQEALWD
700
701
MGAVSMLKNL IHSKHKMIAM GSAAALRNLM ANRPAKYKDA NIMSPGSSLP
750
751
SLHVRKQKAL EAELDAQHLS ETFDNIDNLS PKASHRSKQR HKQSLYGDYV
800
801
FDTNRHDDNR SDNFNTGNMT VLSPYLNTTV LPSSSSSRGS LDSSRSEKDR
850
851
SLERERGIGL GNYHPATENP GTSSKRGLQI STTAAQIAKV MEEVSAIHTS
900
901
QEDRSSGSTT ELHCVTDERN ALRRSSAAHT HSNTYNFTKS ENSNRTCSMP
950
951
YAKLEYKRSS NDSLNSVSSS DGYGKRGQMK PSIESYSEDD ESKFCSYGQY
1000
1001
PADLAHKIHS ANHMDDNDGE LDTPINYSLK YSDEQLNSGR QSPSQNERWA
1050
1051
RPKHIIEDEI KQSEQRQSRN QSTTYPVYTE STDDKHLKFQ PHFGQQECVS
1100
1101
PYRSRGANGS ETNRVGSNHG INQNVSQSLC QEDDYEDDKP TNYSERYSEE
1150
1151
EQHEEEERPT NYSIKYNEEK RHVDQPIDYS LKYATDIPSS QKQSFSFSKS
1200
1201
SSGQSSKTEH MSSSSENTST PSSNAKRQNQ LHPSSAQSRS GQPQKAATCK
1250
1251
VSSINQETIQ TYCVEDTPIC FSRCSSLSSL SSAEDEIGCN QTTQEADSAN
1300
1301
TLQIAEIKEK IGTRSAEDPV SEVPAVSQHP RTKSSRLQGS SLSSESARHK
1350
1351
AVEFSSGAKS PSKSGAQTPK SPPEHYVQET PLMFSRCTSV SSLDSFESRS
1400
1401
IASSVQSEPC SGMVSGIISP SDLPDSPGQT MPPSRSKTPP PPPQTAQTKR
1450
1451
EVPKNKAPTA EKRESGPKQA AVNAAVQRVQ VLPDADTLLH FATESTPDGF
1500
1501
SCSSSLSALS LDEPFIQKDV ELRIMPPVQE NDNGNETESE QPKESNENQE
1550
1551
KEAEKTIDSE KDLLDDSDDD DIEILEECII SAMPTKSSRK AKKPAQTASK
1600
1601
LPPPVARKPS QLPVYKLLPS QNRLQPQKHV SFTPGDDMPR VYCVEGTPIN
1650
1651
FSTATSLSDL TIESPPNELA AGEGVRGGAQ SGEFEKRDTI PTEGRSTDEA
1700
1701
QGGKTSSVTI PELDDNKAEE GDILAECINS AMPKGKSHKP FRVKKIMDQV
1750
1751
QQASASSSAP NKNQLDGKKK KPTSPVKPIP QNTEYRTRVR KNADSKNNLN
1800
1801
AERVFSDNKD SKKQNLKNNS KVFNDKLPNN EDRVRGSFAF DSPHHYTPIE
1850
1851
GTPYCFSRND SLSSLDFDDD DVDLSREKAE LRKAKENKES EAKVTSHTEL
1900
1901
TSNQQSANKT QAIAKQPINR GQPKPILQKQ STFPQSSKDI PDRGAATDEK
1950
1951
LQNFAIENTP VCFSHNSSLS SLSDIDQENN NKENEPIKET EPPDSQGEPS
2000
2001
KPQASGYAPK SFHVEDTPVC FSRNSSLSSL SIDSEDDLLQ ECISSAMPKK
2050
2051
KKPSRLKGDN EKHSPRNMGG ILGEDLTLDL KDIQRPDSEH GLSPDSENFD
2100
2101
WKAIQEGANS IVSSLHQAAA AACLSRQASS DSDSILSLKS GISLGSPFHL
2150
2151
TPDQEEKPFT SNKGPRILKP GEKSTLETKK IESESKGIKG GKKVYKSLIT
2200
2201
GKVRSNSEIS GQMKQPLQAN MPSISRGRTM IHIPGVRNSS SSTSPVSKKG
2250
2251
PPLKTPASKS PSEGQTATTS PRGAKPSVKS ELSPVARQTS QIGGSSKAPS
2300
2301
RSGSRDSTPS RPAQQPLSRP IQSPGRNSIS PGRNGISPPN KLSQLPRTSS
2350
2351
PSTASTKSSG SGKMSYTSPG RQMSQQNLTK QTGLSKNASS IPRSESASKG
2400
2401
LNQMNNGNGA NKKVELSRMS STKSSGSESD RSERPVLVRQ STFIKEAPSP
2450
2451
TLRRKLEESA SFESLSPSSR PASPTRSQAQ TPVLSPSLPD MSLSTHSSVQ
2500
2501
AGGWRKLPPN LSPTIEYNDG RPAKRHDIAR SHSESPSRLP INRSGTWKRE
2550
2551
HSKHSSSLPR VSTWRRTGSS SSILSASSES SEKAKSEDEK HVNSISGTKQ
2600
2601
SKENQVSAKG TWRKIKENEF SPTNSTSQTV SSGATNGAES KTLIYQMAPA
2650
2651
VSKTEDVWVR IEDCPINNPR SGRSPTGNTP PVIDSVSEKA NPNIKDSKDN
2700
2701
QAKQNVGNGS VPMRTVGLEN RLNSFIQVDA PDQKGTEIKP GQNNPVPVSE
2750
2751
TNESSIVERT PFSSSSSSKH SSPSGTVAAR VTPFNYNPSP RKSSADSTSA
2800
2801
RPSQIPTPVN NNTKKRDSKT DSTESSGTQS PKRHSGSYLV TSV       
2843
 

Show the unformatted sequence.

Checksums:
CRC64:77E194AE4A91DC5A
MD5:751c3a38c377d9a228438cf36427095e

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
APC_15aa 1021 - 1031 1JPP C 1021 - 1031 Jmol OpenAstexViewer
1021 - 1034 1JPP D 1021 - 1034 Jmol OpenAstexViewer
APC_N_CC 4 - 55 1DEB A 4 - 55 Jmol OpenAstexViewer
B 4 - 55 Jmol OpenAstexViewer
APC_r 1486 - 1498 1T08 C 1486 - 1498 Jmol OpenAstexViewer
1486 - 1509 1TH1 C 1486 - 1509 Jmol OpenAstexViewer
D 1486 - 1509 Jmol OpenAstexViewer
1V18 B 1486 - 1509 Jmol OpenAstexViewer
APC_rep 393 - 466 3NMZ A 393 - 466 Jmol OpenAstexViewer
B 393 - 466 Jmol OpenAstexViewer
397 - 466 3AU3 A 397 - 466 Jmol OpenAstexViewer
401 - 466 3QHE A 401 - 466 Jmol OpenAstexViewer
402 - 466 3QHE C 402 - 466 Jmol OpenAstexViewer
407 - 466 3NMW A 407 - 466 Jmol OpenAstexViewer
B 407 - 466 Jmol OpenAstexViewer
3NMX A 407 - 466 Jmol OpenAstexViewer
B 407 - 466 Jmol OpenAstexViewer
C 407 - 466 Jmol OpenAstexViewer
3T7U A 407 - 466 Jmol OpenAstexViewer
B 407 - 466 Jmol OpenAstexViewer
4YJE A 407 - 466 Jmol OpenAstexViewer
4YJL A 407 - 466 Jmol OpenAstexViewer
B 407 - 466 Jmol OpenAstexViewer
C 407 - 466 Jmol OpenAstexViewer
D 407 - 466 Jmol OpenAstexViewer
E 407 - 466 Jmol OpenAstexViewer
F 407 - 466 Jmol OpenAstexViewer
4YK6 A 407 - 466 Jmol OpenAstexViewer
5B6G A 407 - 466 Jmol OpenAstexViewer
5IZ6 A 407 - 466 Jmol OpenAstexViewer
5IZ8 A 407 - 466 Jmol OpenAstexViewer
B 407 - 466 Jmol OpenAstexViewer
5IZ9 A 407 - 466 Jmol OpenAstexViewer
5IZA A 407 - 466 Jmol OpenAstexViewer
Arm 512 - 553 3AU3 A 512 - 553 Jmol OpenAstexViewer
3NMW A 512 - 553 Jmol OpenAstexViewer
B 512 - 553 Jmol OpenAstexViewer
3NMX A 512 - 553 Jmol OpenAstexViewer
B 512 - 553 Jmol OpenAstexViewer
C 512 - 553 Jmol OpenAstexViewer
3NMZ A 512 - 553 Jmol OpenAstexViewer
B 512 - 553 Jmol OpenAstexViewer
3QHE A 512 - 553 Jmol OpenAstexViewer
C 512 - 553 Jmol OpenAstexViewer
3T7U A 512 - 553 Jmol OpenAstexViewer
B 512 - 553 Jmol OpenAstexViewer
4YJE A 512 - 553 Jmol OpenAstexViewer
4YJL A 512 - 553 Jmol OpenAstexViewer
B 512 - 553 Jmol OpenAstexViewer
C 512 - 553 Jmol OpenAstexViewer
D 512 - 553 Jmol OpenAstexViewer
E 512 - 553 Jmol OpenAstexViewer
F 512 - 553 Jmol OpenAstexViewer
4YK6 A 512 - 553 Jmol OpenAstexViewer
5B6G A 512 - 553 Jmol OpenAstexViewer
5IZ6 A 512 - 553 Jmol OpenAstexViewer
5IZ8 A 512 - 553 Jmol OpenAstexViewer
B 512 - 553 Jmol OpenAstexViewer
5IZ9 A 512 - 553 Jmol OpenAstexViewer
5IZA A 512 - 553 Jmol OpenAstexViewer
649 - 689 3AU3 A 649 - 689 Jmol OpenAstexViewer
3NMW A 649 - 689 Jmol OpenAstexViewer
B 649 - 689 Jmol OpenAstexViewer
3NMX A 649 - 689 Jmol OpenAstexViewer
B 649 - 689 Jmol OpenAstexViewer
C 649 - 689 Jmol OpenAstexViewer
3NMZ A 649 - 689 Jmol OpenAstexViewer
B 649 - 689 Jmol OpenAstexViewer
3QHE A 649 - 689 Jmol OpenAstexViewer
C 649 - 689 Jmol OpenAstexViewer
3T7U A 649 - 689 Jmol OpenAstexViewer
B 649 - 689 Jmol OpenAstexViewer
4YJE A 649 - 689 Jmol OpenAstexViewer
4YJL A 649 - 689 Jmol OpenAstexViewer
B 649 - 689 Jmol OpenAstexViewer
C 649 - 689 Jmol OpenAstexViewer
D 649 - 689 Jmol OpenAstexViewer
E 649 - 689 Jmol OpenAstexViewer
F 649 - 689 Jmol OpenAstexViewer
4YK6 A 649 - 689 Jmol OpenAstexViewer
5B6G A 649 - 689 Jmol OpenAstexViewer
5IZ6 A 649 - 689 Jmol OpenAstexViewer
5IZ8 A 649 - 689 Jmol OpenAstexViewer
B 649 - 689 Jmol OpenAstexViewer
5IZ9 A 649 - 689 Jmol OpenAstexViewer
5IZA A 649 - 689 Jmol OpenAstexViewer
Arm_APC_u3 732 - 733 3NMZ B 732 - 733 Jmol OpenAstexViewer
732 - 734 3T7U A 732 - 734 Jmol OpenAstexViewer
B 732 - 734 Jmol OpenAstexViewer
732 - 736 3NMX A 732 - 736 Jmol OpenAstexViewer
3NMZ A 732 - 736 Jmol OpenAstexViewer
4YJL A 732 - 736 Jmol OpenAstexViewer
732 - 737 3NMX B 732 - 737 Jmol OpenAstexViewer
C 732 - 737 Jmol OpenAstexViewer
4YJL B 732 - 737 Jmol OpenAstexViewer
C 732 - 737 Jmol OpenAstexViewer
732 - 738 3NMW A 732 - 738 Jmol OpenAstexViewer
B 732 - 738 Jmol OpenAstexViewer
4YJE A 732 - 738 Jmol OpenAstexViewer
4YJL D 732 - 738 Jmol OpenAstexViewer
E 732 - 738 Jmol OpenAstexViewer
F 732 - 738 Jmol OpenAstexViewer
5IZ9 A 732 - 738 Jmol OpenAstexViewer
732 - 741 4YK6 A 732 - 741 Jmol OpenAstexViewer
5B6G A 732 - 741 Jmol OpenAstexViewer
5IZ6 A 732 - 741 Jmol OpenAstexViewer
732 - 743 5IZ8 A 732 - 743 Jmol OpenAstexViewer
5IZA A 732 - 743 Jmol OpenAstexViewer
EB1_binding 2837 - 2843 3RL7 G 2837 - 2843 Jmol OpenAstexViewer
2838 - 2842 3RL7 H 2838 - 2842 Jmol OpenAstexViewer
I 2838 - 2842 Jmol OpenAstexViewer
2838 - 2843 3RL7 J 2838 - 2843 Jmol OpenAstexViewer
3RL8 F 2838 - 2843 Jmol OpenAstexViewer
4G69 B 2838 - 2843 Jmol OpenAstexViewer
2839 - 2842 3RL7 L 2839 - 2842 Jmol OpenAstexViewer
2839 - 2843 3RL7 K 2839 - 2843 Jmol OpenAstexViewer
SAMP 1578 - 1588 2RQU B 1578 - 1588 Jmol OpenAstexViewer
2034 - 2049 1EMU B 2035 - 2050 Jmol OpenAstexViewer
Suppressor_APC 130 - 207 1M5I A 130 - 207 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.