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7  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TNR5_HUMAN (P25942)

Summary

This is the summary of UniProt entry TNR5_HUMAN (P25942).

Description: Tumor necrosis factor receptor superfamily member 5
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 277 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 20
Pfam TNFR_c6 62 103
transmembrane n/a 194 215
low_complexity n/a 196 214
disorder n/a 223 246
disorder n/a 249 277

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P25942. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVRLPLQCVL WGCLLTAVHP EPPTACREKQ YLINSQCCSL CQPGQKLVSD
50
51
CTEFTETECL PCGESEFLDT WNRETHCHQH KYCDPNLGLR VQQKGTSETD
100
101
TICTCEEGWH CTSEACESCV LHRSCSPGFG VKQIATGVSD TICEPCPVGF
150
151
FSNVSSAFEK CHPWTSCETK DLVVQQAGTN KTDVVCGPQD RLRALVVIPI
200
201
IFGILFAILL VLVFIKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP
250
251
VQETLHGCQP VTQEDGKESR ISVQERQ                         
277
 

Show the unformatted sequence.

Checksums:
CRC64:BC8776EC2C4A5680
MD5:667cc2129cc2bfc456503a1c0af0dd02

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
TNFR_c6 62 - 103 3QD6 R 62 - 103 Jmol OpenAstexViewer
S 62 - 103 Jmol OpenAstexViewer
T 62 - 103 Jmol OpenAstexViewer
U 62 - 103 Jmol OpenAstexViewer
5DMI A 62 - 103 Jmol OpenAstexViewer
5DMJ A 62 - 103 Jmol OpenAstexViewer
D 62 - 103 Jmol OpenAstexViewer
F 62 - 103 Jmol OpenAstexViewer
5IHL A 62 - 103 Jmol OpenAstexViewer
D 62 - 103 Jmol OpenAstexViewer
F 62 - 103 Jmol OpenAstexViewer
H 62 - 103 Jmol OpenAstexViewer
6FAX R 62 - 103 Jmol OpenAstexViewer
6PE8 T 62 - 103 Jmol OpenAstexViewer
U 62 - 103 Jmol OpenAstexViewer
6PE9 G 62 - 103 Jmol OpenAstexViewer
I 62 - 103 Jmol OpenAstexViewer
J 62 - 103 Jmol OpenAstexViewer
U 62 - 103 Jmol OpenAstexViewer
V 62 - 103 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.