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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: IKBA_HUMAN (P25963)

Summary

This is the summary of UniProt entry IKBA_HUMAN (P25963).

Description: NF-kappa-B inhibitor alpha
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 317 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 3 42
disorder n/a 45 68
Pfam Ank 111 142
Pfam Ank 143 176
Pfam Ank 182 213
Pfam Ank 216 248
disorder n/a 276 277
disorder n/a 280 297
low_complexity n/a 281 301

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P25963. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MFQAAERPQE WAMEGPRDGL KKERLLDDRH DSGLDSMKDE EYEQMVKELQ
50
51
EIRLEPQEVP RGSEPWKQQL TEDGDSFLHL AIIHEEKALT MEVIRQVKGD
100
101
LAFLNFQNNL QQTPLHLAVI TNQPEIAEAL LGAGCDPELR DFRGNTPLHL
150
151
ACEQGCLASV GVLTQSCTTP HLHSILKATN YNGHTCLHLA SIHGYLGIVE
200
201
LLVSLGADVN AQEPCNGRTA LHLAVDLQNP DLVSLLLKCG ADVNRVTYQG
250
251
YSPYQLTWGR PSTRIQQQLG QLTLENLQML PESEDEESYD TESEFTEFTE
300
301
DELPYDDCVF GGQRLTL                                    
317
 

Show the unformatted sequence.

Checksums:
CRC64:088B313226786395
MD5:2c48504df3c20315ce424d3a33c7f711

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Ank 111 - 142 1IKN D 111 - 142 Jmol OpenAstexViewer
1NFI E 111 - 142 Jmol OpenAstexViewer
F 111 - 142 Jmol OpenAstexViewer
143 - 176 1IKN D 143 - 176 Jmol OpenAstexViewer
1NFI E 143 - 176 Jmol OpenAstexViewer
F 143 - 176 Jmol OpenAstexViewer
182 - 213 1IKN D 182 - 213 Jmol OpenAstexViewer
1NFI E 182 - 213 Jmol OpenAstexViewer
F 182 - 213 Jmol OpenAstexViewer
216 - 248 1IKN D 216 - 248 Jmol OpenAstexViewer
1NFI E 216 - 248 Jmol OpenAstexViewer
F 216 - 248 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.