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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ITB7_HUMAN (P26010)

Summary

This is the summary of UniProt entry ITB7_HUMAN (P26010).

Description: Integrin beta-7
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 798 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 19
low_complexity n/a 6 13
disorder n/a 24 30
disorder n/a 32 33
disorder n/a 36 39
Pfam PSI_integrin 43 92
low_complexity n/a 73 88
disorder n/a 98 120
disorder n/a 122 130
Pfam Integrin_beta 147 393
disorder n/a 248 250
disorder n/a 411 416
disorder n/a 418 421
disorder n/a 423 425
low_complexity n/a 540 556
Pfam EGF_2 605 635
disorder n/a 713 714
low_complexity n/a 725 744
transmembrane n/a 726 746
Pfam Integrin_b_cyt 747 791
disorder n/a 797 798

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P26010. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVALPMVLVL LLVLSRGESE LDAKIPSTGD ATEWRNPHLS MLGSCQPAPS
50
51
CQKCILSHPS CAWCKQLNFT ASGEAEARRC ARREELLARG CPLEELEEPR
100
101
GQQEVLQDQP LSQGARGEGA TQLAPQRVRV TLRPGEPQQL QVRFLRAEGY
150
151
PVDLYYLMDL SYSMKDDLER VRQLGHALLV RLQEVTHSVR IGFGSFVDKT
200
201
VLPFVSTVPS KLRHPCPTRL ERCQSPFSFH HVLSLTGDAQ AFEREVGRQS
250
251
VSGNLDSPEG GFDAILQAAL CQEQIGWRNV SRLLVFTSDD TFHTAGDGKL
300
301
GGIFMPSDGH CHLDSNGLYS RSTEFDYPSV GQVAQALSAA NIQPIFAVTS
350
351
AALPVYQELS KLIPKSAVGE LSEDSSNVVQ LIMDAYNSLS STVTLEHSSL
400
401
PPGVHISYES QCEGPEKREG KAEDRGQCNH VRINQTVTFW VSLQATHCLP
450
451
EPHLLRLRAL GFSEELIVEL HTLCDCNCSD TQPQAPHCSD GQGHLQCGVC
500
501
SCAPGRLGRL CECSVAELSS PDLESGCRAP NGTGPLCSGK GHCQCGRCSC
550
551
SGQSSGHLCE CDDASCERHE GILCGGFGRC QCGVCHCHAN RTGRACECSG
600
601
DMDSCISPEG GLCSGHGRCK CNRCQCLDGY YGALCDQCPG CKTPCERHRD
650
651
CAECGAFRTG PLATNCSTAC AHTNVTLALA PILDDGWCKE RTLDNQLFFF
700
701
LVEDDARGTV VLRVRPQEKG ADHTQAIVLG CVGGIVAVGL GLVLAYRLSV
750
751
EIYDRREYSR FEKEQQQLNW KQDSNPLYKS AITTTINPRF QEADSPTL  
798
 

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Checksums:
CRC64:CBE275E0E9992385
MD5:3cee5d803d6afc8d7442dc3521eb0d1c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Integrin_b_cyt 776 - 789 2BRQ C 776 - 789 Jmol OpenAstexViewer
D 776 - 789 Jmol OpenAstexViewer
Integrin_beta 147 - 393 3V4P B 128 - 374 Jmol OpenAstexViewer
D 128 - 374 Jmol OpenAstexViewer
3V4V B 128 - 374 Jmol OpenAstexViewer
D 128 - 374 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.