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9  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PTN3_HUMAN (P26045)

Summary

This is the summary of UniProt entry PTN3_HUMAN (P26045).

Description: Tyrosine-protein phosphatase non-receptor type 3 EC=3.1.3.48
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 913 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 16 17
Pfam FERM_N 33 97
Pfam FERM_M 113 222
Pfam FERM_C 226 316
disorder n/a 361 402
disorder n/a 416 485
low_complexity n/a 453 469
disorder n/a 489 497
Pfam PDZ 510 595
disorder n/a 522 524
disorder n/a 534 538
disorder n/a 540 541
disorder n/a 546 549
Pfam Y_phosphatase 670 900
disorder n/a 757 758

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P26045. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTSRLRALGG RINNIRTSEL PKEKTRSEVI CSIHFLDGVV QTFKVTKQDT
50
51
GQVLLDMVHN HLGVTEKEYF GLQHDDDSVD SPRWLEASKA IRKQLKGGFP
100
101
CTLHFRVRFF IPDPNTLQQE QTRHLYFLQL KMDICEGRLT CPLNSAVVLA
150
151
SYAVQSHFGD YNSSIHHPGY LSDSHFIPDQ NEDFLTKVES LHEQHSGLKQ
200
201
SEAESCYINI ARTLDFYGVE LHSGRDLHNL DLMIGIASAG VAVYRKYICT
250
251
SFYPWVNILK ISFKRKKFFI HQRQKQAESR EHIVAFNMLN YRSCKNLWKS
300
301
CVEHHTFFQA KKLLPQEKNV LSQYWTMGSR NTKKSVNNQY CKKVIGGMVW
350
351
NPAMRRSLSV EHLETKSLPS RSPPITPNWR SPRLRHEIRK PRHSSADNLA
400
401
NEMTYITETE DVFYTYKGSL APQDSDSEVS QNRSPHQESL SENNPAQSYL
450
451
TQKSSSSVSP SSNAPGSCSP DGVDQQLLDD FHRVTKGGST EDASQYYCDK
500
501
NDNGDSYLVL IRITPDEDGK FGFNLKGGVD QKMPLVVSRI NPESPADTCI
550
551
PKLNEGDQIV LINGRDISEH THDQVVMFIK ASRESHSREL ALVIRRRAVR
600
601
SFADFKSEDE LNQLFPEAIF PMCPEGGDTL EGSMAQLKKG LESGTVLIQF
650
651
EQLYRKKPGL AITFAKLPQN LDKNRYKDVL PYDTTRVLLQ GNEDYINASY
700
701
VNMEIPAANL VNKYIATQGP LPHTCAQFWQ VVWDQKLSLI VMLTTLTERG
750
751
RTKCHQYWPD PPDVMNHGGF HIQCQSEDCT IAYVSREMLV TNTQTGEEHT
800
801
VTHLQYVAWP DHGVPDDSSD FLEFVNYVRS LRVDSEPVLV HCSAGIGRTG
850
851
VLVTMETAMC LTERNLPIYP LDIVRKMRDQ RAMMVQTSSQ YKFVCEAILR
900
901
VYEEGLVQML DPS                                        
913
 

Show the unformatted sequence.

Checksums:
CRC64:44FBBFA35A5F2AFF
MD5:6e578dd722a7953f290a41ce737bde2e

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Y_phosphatase 670 - 900 2B49 A 670 - 900 Jmol OpenAstexViewer
4QUM A 670 - 900 Jmol OpenAstexViewer
4QUN A 670 - 900 Jmol OpenAstexViewer
B 670 - 900 Jmol OpenAstexViewer
4RH5 A 670 - 900 Jmol OpenAstexViewer
4RH9 A 670 - 900 Jmol OpenAstexViewer
4RHG A 670 - 900 Jmol OpenAstexViewer
4RI4 A 670 - 900 Jmol OpenAstexViewer
B 670 - 900 Jmol OpenAstexViewer
4RI5 A 670 - 900 Jmol OpenAstexViewer
B 670 - 900 Jmol OpenAstexViewer
4S0G A 670 - 900 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.