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58  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HPPK_ECOLI (P26281)

Summary

This is the summary of UniProt entry HPPK_ECOLI (P26281).

Description: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EC=2.7.6.3
Source organism: Escherichia coli (strain K12) (NCBI taxonomy ID 83333)
Length: 159 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam HPPK 5 134
disorder n/a 52 53

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P26281. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTVAYIAIGS NLASPLEQVN AALKALGDIP ESHILTVSSF YRTPPLGPQD
50
51
QPDYLNAAVA LETSLAPEEL LNHTQRIELQ QGRVRKAERW GPRTLDLDIM
100
101
LFGNEVINTE RLTVPHYDMK NRGFMLWPLF EIAPELVFPD GEMLRQILHT
150
151
RAFDKLNKW                                             
159
 

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Checksums:
CRC64:67301CD634D0A174
MD5:8ec3f596357e83c64d4a301a0a64841c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
HPPK 5 - 134 1DY3 A 4 - 133 Show 3D Structure View in InterPro
1EQ0 A 4 - 133 Show 3D Structure View in InterPro
1EQM A 4 - 133 Show 3D Structure View in InterPro
1EX8 A 4 - 133 Show 3D Structure View in InterPro
1F9H A 4 - 133 Show 3D Structure View in InterPro
1G4C A 4 - 133 Show 3D Structure View in InterPro
B 204 - 333 Show 3D Structure View in InterPro
1HKA A 4 - 133 Show 3D Structure View in InterPro
1HQ2 A 4 - 133 Show 3D Structure View in InterPro
1IM6 A 4 - 133 Show 3D Structure View in InterPro
1KBR A 4 - 133 Show 3D Structure View in InterPro
1Q0N A 4 - 133 Show 3D Structure View in InterPro
1RAO A 4 - 133 Show 3D Structure View in InterPro
1RB0 A 4 - 133 Show 3D Structure View in InterPro
1RTZ A 4 - 133 Show 3D Structure View in InterPro
1RU1 A 4 - 133 Show 3D Structure View in InterPro
B 204 - 333 Show 3D Structure View in InterPro
1RU2 A 4 - 133 Show 3D Structure View in InterPro
1TMJ A 4 - 133 Show 3D Structure View in InterPro
1TMM A 4 - 133 Show 3D Structure View in InterPro
B 204 - 333 Show 3D Structure View in InterPro
2F63 A 4 - 133 Show 3D Structure View in InterPro
2F65 A 4 - 133 Show 3D Structure View in InterPro
3HCX A 4 - 133 Show 3D Structure View in InterPro
3HD1 A 4 - 133 Show 3D Structure View in InterPro
3HD2 A 4 - 133 Show 3D Structure View in InterPro
3HSD A 4 - 133 Show 3D Structure View in InterPro
B 4 - 133 Show 3D Structure View in InterPro
3HSG A 4 - 133 Show 3D Structure View in InterPro
3HSJ A 4 - 133 Show 3D Structure View in InterPro
3HSZ A 4 - 133 Show 3D Structure View in InterPro
3HT0 A 4 - 133 Show 3D Structure View in InterPro
3ILI A 4 - 133 Show 3D Structure View in InterPro
3ILJ A 4 - 133 Show 3D Structure View in InterPro
3ILL A 4 - 133 Show 3D Structure View in InterPro
3ILO A 4 - 133 Show 3D Structure View in InterPro
3IP0 A 4 - 133 Show 3D Structure View in InterPro
3KUE A 4 - 133 Show 3D Structure View in InterPro
3KUG A 4 - 133 Show 3D Structure View in InterPro
3KUH A 4 - 133 Show 3D Structure View in InterPro
3UD5 A 4 - 133 Show 3D Structure View in InterPro
3UDE A 4 - 133 Show 3D Structure View in InterPro
3UDV A 4 - 133 Show 3D Structure View in InterPro
4F7V A 4 - 133 Show 3D Structure View in InterPro
4M5G A 4 - 133 Show 3D Structure View in InterPro
4M5H A 4 - 133 Show 3D Structure View in InterPro
4M5I A 4 - 133 Show 3D Structure View in InterPro
4M5J A 4 - 133 Show 3D Structure View in InterPro
4M5K A 4 - 133 Show 3D Structure View in InterPro
4M5L A 4 - 133 Show 3D Structure View in InterPro
4M5M A 4 - 133 Show 3D Structure View in InterPro
4M5N A 4 - 133 Show 3D Structure View in InterPro
B 4 - 133 Show 3D Structure View in InterPro
5ETK A 4 - 133 Show 3D Structure View in InterPro
5ETL A 4 - 133 Show 3D Structure View in InterPro
B 4 - 133 Show 3D Structure View in InterPro
C 4 - 133 Show 3D Structure View in InterPro
D 4 - 133 Show 3D Structure View in InterPro
5ETM A 4 - 133 Show 3D Structure View in InterPro
5ETN A 4 - 133 Show 3D Structure View in InterPro
5ETO A 4 - 133 Show 3D Structure View in InterPro
5ETP A 4 - 133 Show 3D Structure View in InterPro
6AN4 A 4 - 133 Show 3D Structure View in InterPro
6AN6 A 4 - 133 Show 3D Structure View in InterPro
B 4 - 133 Show 3D Structure View in InterPro
7KDO A 4 - 133 Show 3D Structure View in InterPro
7KDR A 4 - 133 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;