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7  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DNMT1_HUMAN (P26358)

Summary

This is the summary of UniProt entry DNMT1_HUMAN (P26358).

Description: DNA (cytosine-5)-methyltransferase 1 EC=2.1.1.37
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1616 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 6
disorder n/a 10 12
Pfam DMAP_binding 16 105
disorder n/a 64 66
disorder n/a 89 355
low_complexity n/a 203 214
low_complexity n/a 228 243
coiled_coil n/a 230 250
low_complexity n/a 272 284
low_complexity n/a 295 305
low_complexity n/a 312 335
disorder n/a 358 384
disorder n/a 386 387
Pfam DNMT1-RFD 399 534
disorder n/a 527 528
low_complexity n/a 593 601
disorder n/a 598 616
disorder n/a 618 619
disorder n/a 639 641
disorder n/a 643 644
Pfam zf-CXXC 645 691
disorder n/a 687 726
low_complexity n/a 715 728
Pfam BAH 755 880
disorder n/a 847 851
disorder n/a 878 880
Pfam BAH 931 1100
disorder n/a 963 964
disorder n/a 1012 1021
disorder n/a 1096 1130
low_complexity n/a 1106 1118
Pfam DNA_methylase 1139 1594
disorder n/a 1207 1209
disorder n/a 1455 1464
disorder n/a 1530 1541
low_complexity n/a 1597 1614
disorder n/a 1606 1616

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P26358. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPARTAPARV PTLAVPAISL PDDVRRRLKD LERDSLTEKE CVKEKLNLLH
50
51
EFLQTEIKNQ LCDLETKLRK EELSEEGYLA KVKSLLNKDL SLENGAHAYN
100
101
REVNGRLENG NQARSEARRV GMADANSPPK PLSKPRTPRR SKSDGEAKPE
150
151
PSPSPRITRK STRQTTITSH FAKGPAKRKP QEESERAKSD ESIKEEDKDQ
200
201
DEKRRRVTSR ERVARPLPAE EPERAKSGTR TEKEEERDEK EEKRLRSQTK
250
251
EPTPKQKLKE EPDREARAGV QADEDEDGDE KDEKKHRSQP KDLAAKRRPE
300
301
EKEPEKVNPQ ISDEKDEDEK EEKRRKTTPK EPTEKKMARA KTVMNSKTHP
350
351
PKCIQCGQYL DDPDLKYGQH PPDAVDEPQM LTNEKLSIFD ANESGFESYE
400
401
ALPQHKLTCF SVYCKHGHLC PIDTGLIEKN IELFFSGSAK PIYDDDPSLE
450
451
GGVNGKNLGP INEWWITGFD GGEKALIGFS TSFAEYILMD PSPEYAPIFG
500
501
LMQEKIYISK IVVEFLQSNS DSTYEDLINK IETTVPPSGL NLNRFTEDSL
550
551
LRHAQFVVEQ VESYDEAGDS DEQPIFLTPC MRDLIKLAGV TLGQRRAQAR
600
601
RQTIRHSTRE KDRGPTKATT TKLVYQIFDT FFAEQIEKDD REDKENAFKR
650
651
RRCGVCEVCQ QPECGKCKAC KDMVKFGGSG RSKQACQERR CPNMAMKEAD
700
701
DDEEVDDNIP EMPSPKKMHQ GKKKKQNKNR ISWVGEAVKT DGKKSYYKKV
750
751
CIDAETLEVG DCVSVIPDDS SKPLYLARVT ALWEDSSNGQ MFHAHWFCAG
800
801
TDTVLGATSD PLELFLVDEC EDMQLSYIHS KVKVIYKAPS ENWAMEGGMD
850
851
PESLLEGDDG KTYFYQLWYD QDYARFESPP KTQPTEDNKF KFCVSCARLA
900
901
EMRQKEIPRV LEQLEDLDSR VLYYSATKNG ILYRVGDGVY LPPEAFTFNI
950
951
KLSSPVKRPR KEPVDEDLYP EHYRKYSDYI KGSNLDAPEP YRIGRIKEIF
1000
1001
CPKKSNGRPN ETDIKIRVNK FYRPENTHKS TPASYHADIN LLYWSDEEAV
1050
1051
VDFKAVQGRC TVEYGEDLPE CVQVYSMGGP NRFYFLEAYN AKSKSFEDPP
1100
1101
NHARSPGNKG KGKGKGKGKP KSQACEPSEP EIEIKLPKLR TLDVFSGCGG
1150
1151
LSEGFHQAGI SDTLWAIEMW DPAAQAFRLN NPGSTVFTED CNILLKLVMA
1200
1201
GETTNSRGQR LPQKGDVEML CGGPPCQGFS GMNRFNSRTY SKFKNSLVVS
1250
1251
FLSYCDYYRP RFFLLENVRN FVSFKRSMVL KLTLRCLVRM GYQCTFGVLQ
1300
1301
AGQYGVAQTR RRAIILAAAP GEKLPLFPEP LHVFAPRACQ LSVVVDDKKF
1350
1351
VSNITRLSSG PFRTITVRDT MSDLPEVRNG ASALEISYNG EPQSWFQRQL
1400
1401
RGAQYQPILR DHICKDMSAL VAARMRHIPL APGSDWRDLP NIEVRLSDGT
1450
1451
MARKLRYTHH DRKNGRSSSG ALRGVCSCVE AGKACDPAAR QFNTLIPWCL
1500
1501
PHTGNRHNHW AGLYGRLEWD GFFSTTVTNP EPMGKQGRVL HPEQHRVVSV
1550
1551
RECARSQGFP DTYRLFGNIL DKHRQVGNAV PPPLAKAIGL EIKLCMLAKA
1600
1601
RESASAKIKE EEAAKD                                     
1616
 

Show the unformatted sequence.

Checksums:
CRC64:1E833192D22AFA5B
MD5:aa4d2df629c398a84bfe0389ad4bb83a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
BAH 755 - 880 3PTA A 755 - 880 Jmol OpenAstexViewer
3SWR A 755 - 880 Jmol OpenAstexViewer
4WXX A 755 - 880 Jmol OpenAstexViewer
B 755 - 880 Jmol OpenAstexViewer
4YOC A 755 - 880 Jmol OpenAstexViewer
931 - 1100 3PTA A 931 - 1100 Jmol OpenAstexViewer
3SWR A 931 - 1100 Jmol OpenAstexViewer
4WXX A 931 - 1100 Jmol OpenAstexViewer
B 931 - 1100 Jmol OpenAstexViewer
4YOC A 931 - 1100 Jmol OpenAstexViewer
DNA_methylase 1139 - 1594 3PTA A 1139 - 1594 Jmol OpenAstexViewer
3SWR A 1139 - 1594 Jmol OpenAstexViewer
4WXX A 1139 - 1594 Jmol OpenAstexViewer
B 1139 - 1594 Jmol OpenAstexViewer
4YOC A 1139 - 1594 Jmol OpenAstexViewer
DNMT1-RFD 399 - 534 5WVO C 399 - 534 Jmol OpenAstexViewer
5YDR B 399 - 534 Jmol OpenAstexViewer
400 - 534 4WXX B 400 - 534 Jmol OpenAstexViewer
401 - 534 3EPZ A 401 - 534 Jmol OpenAstexViewer
4WXX A 401 - 534 Jmol OpenAstexViewer
402 - 534 3EPZ B 402 - 534 Jmol OpenAstexViewer
zf-CXXC 646 - 691 3SWR A 646 - 691 Jmol OpenAstexViewer
647 - 691 3PTA A 647 - 691 Jmol OpenAstexViewer
649 - 691 4WXX A 649 - 691 Jmol OpenAstexViewer
B 649 - 691 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.