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10  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PTBP1_HUMAN (P26599)

Summary

This is the summary of UniProt entry PTBP1_HUMAN (P26599).

Description: Polypyrimidine tract-binding protein 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 531 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
low_complexity n/a 31 43
Pfam RRM_5 40 152
disorder n/a 40 51
disorder n/a 138 139
disorder n/a 141 142
low_complexity n/a 161 178
Pfam RRM_1 186 252
disorder n/a 274 285
low_complexity n/a 305 334
Pfam RRM_5 309 433
disorder n/a 390 394
disorder n/a 410 434
disorder n/a 441 442
Pfam RRM_1 456 521

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P26599. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDGIVPDIAV GTKRGSDELF STCVTNGPFI MSSNSASAAN GNDSKKFKGD
50
51
SRSAGVPSRV IHIRKLPIDV TEGEVISLGL PFGKVTNLLM LKGKNQAFIE
100
101
MNTEEAANTM VNYYTSVTPV LRGQPIYIQF SNHKELKTDS SPNQARAQAA
150
151
LQAVNSVQSG NLALAASAAA VDAGMAMAGQ SPVLRIIVEN LFYPVTLDVL
200
201
HQIFSKFGTV LKIITFTKNN QFQALLQYAD PVSAQHAKLS LDGQNIYNAC
250
251
CTLRIDFSKL TSLNVKYNND KSRDYTRPDL PSGDSQPSLD QTMAAAFGLS
300
301
VPNVHGALAP LAIPSAAAAA AAAGRIAIPG LAGAGNSVLL VSNLNPERVT
350
351
PQSLFILFGV YGDVQRVKIL FNKKENALVQ MADGNQAQLA MSHLNGHKLH
400
401
GKPIRITLSK HQNVQLPREG QEDQGLTKDY GNSPLHRFKK PGSKNFQNIF
450
451
PPSATLHLSN IPPSVSEEDL KVLFSSNGGV VKGFKFFQKD RKMALIQMGS
500
501
VEEAVQALID LHNHDLGENH HLRVSFSKST I                    
531
 

Show the unformatted sequence.

Checksums:
CRC64:BE12D5EA21537BED
MD5:ad5385d79146509cfb8bb0c035e41a61

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
RRM_1 186 - 252 1SJR A 49 - 115 Jmol OpenAstexViewer
2ADB A 186 - 252 Jmol OpenAstexViewer
3ZZY A 186 - 252 Jmol OpenAstexViewer
B 186 - 252 Jmol OpenAstexViewer
3ZZZ A 186 - 252 Jmol OpenAstexViewer
B 186 - 252 Jmol OpenAstexViewer
456 - 521 1QM9 A 123 - 188 Jmol OpenAstexViewer
2ADC A 456 - 521 Jmol OpenAstexViewer
2EVZ A 133 - 198 Jmol OpenAstexViewer
RRM_5 324 - 433 2ADC A 324 - 433 Jmol OpenAstexViewer
2EVZ A 1 - 110 Jmol OpenAstexViewer
335 - 433 1QM9 A 2 - 100 Jmol OpenAstexViewer
41 - 152 2N3O A 41 - 152 Jmol OpenAstexViewer
49 - 146 2AD9 A 49 - 146 Jmol OpenAstexViewer
55 - 141 1SJQ A 13 - 99 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.