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8  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TKT1_ECOLI (P27302)

Summary

This is the summary of UniProt entry TKT1_ECOLI (P27302).

Description: Transketolase 1
Source organism: Escherichia coli (strain K12) (NCBI taxonomy ID 83333)
Length: 663 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam Transketolase_N 3 334
disorder n/a 21 28
disorder n/a 55 58
disorder n/a 91 93
disorder n/a 101 108
disorder n/a 257 265
low_complexity n/a 312 324
Pfam Transket_pyr 353 526
disorder n/a 469 472
disorder n/a 475 479
disorder n/a 481 482
disorder n/a 518 521
Pfam Transketolase_C 540 655

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P27302. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSSRKELANA IRALSMDAVQ KAKSGHPGAP MGMADIAEVL WRDFLKHNPQ
50
51
NPSWADRDRF VLSNGHGSML IYSLLHLTGY DLPMEELKNF RQLHSKTPGH
100
101
PEVGYTAGVE TTTGPLGQGI ANAVGMAIAE KTLAAQFNRP GHDIVDHYTY
150
151
AFMGDGCMME GISHEVCSLA GTLKLGKLIA FYDDNGISID GHVEGWFTDD
200
201
TAMRFEAYGW HVIRDIDGHD AASIKRAVEE ARAVTDKPSL LMCKTIIGFG
250
251
SPNKAGTHDS HGAPLGDAEI ALTREQLGWK YAPFEIPSEI YAQWDAKEAG
300
301
QAKESAWNEK FAAYAKAYPQ EAAEFTRRMK GEMPSDFDAK AKEFIAKLQA
350
351
NPAKIASRKA SQNAIEAFGP LLPEFLGGSA DLAPSNLTLW SGSKAINEDA
400
401
AGNYIHYGVR EFGMTAIANG ISLHGGFLPY TSTFLMFVEY ARNAVRMAAL
450
451
MKQRQVMVYT HDSIGLGEDG PTHQPVEQVA SLRVTPNMST WRPCDQVESA
500
501
VAWKYGVERQ DGPTALILSR QNLAQQERTE EQLANIARGG YVLKDCAGQP
550
551
ELIFIATGSE VELAVAAYEK LTAEGVKARV VSMPSTDAFD KQDAAYRESV
600
601
LPKAVTARVA VEAGIADYWY KYVGLNGAIV GMTTFGESAP AELLFEEFGF
650
651
TVDNVVAKAK ELL                                        
663
 

Show the unformatted sequence.

Checksums:
CRC64:FE6D624ADD11939A
MD5:dccf3c9edddfd9e490612e563185c9b9

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Transket_pyr 353 - 526 1QGD A 353 - 526 Show 3D Structure View in InterPro
B 353 - 526 Show 3D Structure View in InterPro
2R5N A 353 - 526 Show 3D Structure View in InterPro
B 353 - 526 Show 3D Structure View in InterPro
2R8O A 353 - 526 Show 3D Structure View in InterPro
B 353 - 526 Show 3D Structure View in InterPro
2R8P A 353 - 526 Show 3D Structure View in InterPro
B 353 - 526 Show 3D Structure View in InterPro
5HHT A 353 - 526 Show 3D Structure View in InterPro
B 353 - 526 Show 3D Structure View in InterPro
6RJC A 353 - 526 Show 3D Structure View in InterPro
B 353 - 526 Show 3D Structure View in InterPro
6TJ8 A 353 - 526 Show 3D Structure View in InterPro
B 353 - 526 Show 3D Structure View in InterPro
6TJ9 A 353 - 526 Show 3D Structure View in InterPro
B 353 - 526 Show 3D Structure View in InterPro
Transketolase_C 540 - 655 1QGD A 540 - 655 Show 3D Structure View in InterPro
B 540 - 655 Show 3D Structure View in InterPro
2R5N A 540 - 655 Show 3D Structure View in InterPro
B 540 - 655 Show 3D Structure View in InterPro
2R8O A 540 - 655 Show 3D Structure View in InterPro
B 540 - 655 Show 3D Structure View in InterPro
2R8P A 540 - 655 Show 3D Structure View in InterPro
B 540 - 655 Show 3D Structure View in InterPro
5HHT A 540 - 655 Show 3D Structure View in InterPro
B 540 - 655 Show 3D Structure View in InterPro
6RJC A 540 - 655 Show 3D Structure View in InterPro
B 540 - 655 Show 3D Structure View in InterPro
6TJ8 A 540 - 655 Show 3D Structure View in InterPro
B 540 - 655 Show 3D Structure View in InterPro
6TJ9 A 540 - 655 Show 3D Structure View in InterPro
B 540 - 655 Show 3D Structure View in InterPro
Transketolase_N 3 - 334 1QGD A 3 - 334 Show 3D Structure View in InterPro
B 3 - 334 Show 3D Structure View in InterPro
2R5N A 3 - 334 Show 3D Structure View in InterPro
B 3 - 334 Show 3D Structure View in InterPro
2R8O A 3 - 334 Show 3D Structure View in InterPro
B 3 - 334 Show 3D Structure View in InterPro
2R8P A 3 - 334 Show 3D Structure View in InterPro
B 3 - 334 Show 3D Structure View in InterPro
5HHT A 3 - 334 Show 3D Structure View in InterPro
B 3 - 334 Show 3D Structure View in InterPro
6RJC A 3 - 334 Show 3D Structure View in InterPro
B 3 - 334 Show 3D Structure View in InterPro
6TJ8 A 3 - 334 Show 3D Structure View in InterPro
B 3 - 334 Show 3D Structure View in InterPro
6TJ9 A 3 - 334 Show 3D Structure View in InterPro
B 3 - 334 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;