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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MK03_HUMAN (P27361)

Summary

This is the summary of UniProt entry MK03_HUMAN (P27361).

Description: Mitogen-activated protein kinase 3 EC=2.7.11.24
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 379 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
low_complexity n/a 1 11
disorder n/a 2 26
low_complexity n/a 17 28
Pfam Pkinase 42 330

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P27361. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAAAAQGGG GGEPRRTEGV GPGVPGEVEM VKGQPFDVGP RYTQLQYIGE
50
51
GAYGMVSSAY DHVRKTRVAI KKISPFEHQT YCQRTLREIQ ILLRFRHENV
100
101
IGIRDILRAS TLEAMRDVYI VQDLMETDLY KLLKSQQLSN DHICYFLYQI
150
151
LRGLKYIHSA NVLHRDLKPS NLLINTTCDL KICDFGLARI ADPEHDHTGF
200
201
LTEYVATRWY RAPEIMLNSK GYTKSIDIWS VGCILAEMLS NRPIFPGKHY
250
251
LDQLNHILGI LGSPSQEDLN CIINMKARNY LQSLPSKTKV AWAKLFPKSD
300
301
SKALDLLDRM LTFNPNKRIT VEEALAHPYL EQYYDPTDEP VAEEPFTFAM
350
351
ELDDLPKERL KELIFQETAR FQPGVLEAP                       
379
 

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Checksums:
CRC64:E6020CE413EC41F7
MD5:8501faf469e77a9fbdc0166f5a18bcf6

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase 42 - 330 2ZOQ A 42 - 330 Jmol OpenAstexViewer
B 42 - 330 Jmol OpenAstexViewer
4QTB A 42 - 330 Jmol OpenAstexViewer
B 42 - 330 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.