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25  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ARNT_HUMAN (P27540)

Summary

This is the summary of UniProt entry ARNT_HUMAN (P27540).

Description: Aryl hydrocarbon receptor nuclear translocator
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 789 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 50
low_complexity n/a 24 34
disorder n/a 52 104
Pfam HLH 90 143
disorder n/a 142 156
Pfam PAS 163 270
disorder n/a 220 225
disorder n/a 250 251
low_complexity n/a 251 262
disorder n/a 322 324
Pfam PAS_11 360 469
disorder n/a 462 463
disorder n/a 465 789
low_complexity n/a 631 643
low_complexity n/a 649 662
low_complexity n/a 669 680
low_complexity n/a 682 696
low_complexity n/a 723 736
low_complexity n/a 743 756

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P27540. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAATTANPEM TSDVPSLGPA IASGNSGPGI QGGGAIVQRA IKRRPGLDFD
50
51
DDGEGNSKFL RCDDDQMSND KERFARSDDE QSSADKERLA RENHSEIERR
100
101
RRNKMTAYIT ELSDMVPTCS ALARKPDKLT ILRMAVSHMK SLRGTGNTST
150
151
DGSYKPSFLT DQELKHLILE AADGFLFIVS CETGRVVYVS DSVTPVLNQP
200
201
QSEWFGSTLY DQVHPDDVDK LREQLSTSEN ALTGRILDLK TGTVKKEGQQ
250
251
SSMRMCMGSR RSFICRMRCG SSSVDPVSVN RLSFVRNRCR NGLGSVKDGE
300
301
PHFVVVHCTG YIKAWPPAGV SLPDDDPEAG QGSKFCLVAI GRLQVTSSPN
350
351
CTDMSNVCQP TEFISRHNIE GIFTFVDHRC VATVGYQPQE LLGKNIVEFC
400
401
HPEDQQLLRD SFQQVVKLKG QVLSVMFRFR SKNQEWLWMR TSSFTFQNPY
450
451
SDEIEYIICT NTNVKNSSQE PRPTLSNTIQ RPQLGPTANL PLEMGSGQLA
500
501
PRQQQQQTEL DMVPGRDGLA SYNHSQVVQP VTTTGPEHSK PLEKSDGLFA
550
551
QDRDPRFSEI YHNINADQSK GISSSTVPAT QQLFSQGNTF PPTPRPAENF
600
601
RNSGLAPPVT IVQPSASAGQ MLAQISRHSN PTQGATPTWT PTTRSGFSAQ
650
651
QVATQATAKT RTSQFGVGSF QTPSSFSSMS LPGAPTASPG AAAYPSLTNR
700
701
GSNFAPETGQ TAGQFQTRTA EGVGVWPQWQ GQQPHHRSSS SEQHVQQPPA
750
751
QQPGQPEVFQ EMLSMLGDQS NSYNNEEFPD LTMFPPFSE            
789
 

Show the unformatted sequence.

Checksums:
CRC64:2E278F8E62BFBF6D
MD5:a5c61c712a8e665d5a485d4734e5ab14

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
HLH 90 - 142 5V0L A 90 - 142 Show 3D Structure View in InterPro
90 - 143 5NJ8 B 90 - 143 Show 3D Structure View in InterPro
D 90 - 143 Show 3D Structure View in InterPro
PAS 163 - 269 5NJ8 B 163 - 269 Show 3D Structure View in InterPro
D 163 - 269 Show 3D Structure View in InterPro
5V0L A 163 - 269 Show 3D Structure View in InterPro
PAS_11 360 - 464 2B02 A 360 - 464 Show 3D Structure View in InterPro
4EQ1 A 360 - 464 Show 3D Structure View in InterPro
B 360 - 464 Show 3D Structure View in InterPro
360 - 465 2A24 B 9 - 114 Show 3D Structure View in InterPro
2HV1 A 9 - 114 Show 3D Structure View in InterPro
B 9 - 114 Show 3D Structure View in InterPro
360 - 466 4H6J B 360 - 466 Show 3D Structure View in InterPro
4XT2 D 360 - 466 Show 3D Structure View in InterPro
360 - 467 3F1P B 360 - 467 Show 3D Structure View in InterPro
3H7W B 360 - 467 Show 3D Structure View in InterPro
3H82 B 360 - 467 Show 3D Structure View in InterPro
4GHI B 360 - 467 Show 3D Structure View in InterPro
5TBM B 360 - 467 Show 3D Structure View in InterPro
5UFP B 360 - 467 Show 3D Structure View in InterPro
6CZW B 360 - 467 Show 3D Structure View in InterPro
6D09 B 360 - 467 Show 3D Structure View in InterPro
6D0B B 360 - 467 Show 3D Structure View in InterPro
6D0C B 360 - 467 Show 3D Structure View in InterPro
360 - 468 3F1N B 360 - 468 Show 3D Structure View in InterPro
3F1O B 360 - 468 Show 3D Structure View in InterPro
4GS9 B 360 - 468 Show 3D Structure View in InterPro
4XT2 B 360 - 468 Show 3D Structure View in InterPro
360 - 469 1X0O A 9 - 118 Show 3D Structure View in InterPro
2K7S A 9 - 118 Show 3D Structure View in InterPro
361 - 464 4LPZ A 361 - 464 Show 3D Structure View in InterPro
B 361 - 464 Show 3D Structure View in InterPro
4PKY A 361 - 464 Show 3D Structure View in InterPro
D 361 - 464 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;