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36  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PYR1_HUMAN (P27708)

Summary

This is the summary of UniProt entry PYR1_HUMAN (P27708).

Description: CAD protein Glutamine-dependent carbamoyl-phosphate synthase Aspartate carbamoyltransferase Dihydroorotase
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 2225 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam CPSase_sm_chain 1 138
disorder n/a 150 151
Pfam GATase 179 356
disorder n/a 310 311
disorder n/a 364 386
disorder n/a 390 392
low_complexity n/a 396 406
Pfam CPSase_L_D2 514 718
low_complexity n/a 531 545
low_complexity n/a 555 568
low_complexity n/a 684 696
Pfam CPSase_L_D3 800 881
Pfam CPSase_L_D2 1047 1250
low_complexity n/a 1134 1151
Pfam MGS 1327 1428
Pfam Amidohydro_1 1462 1745
low_complexity n/a 1507 1518
disorder n/a 1655 1662
disorder n/a 1664 1665
disorder n/a 1691 1701
disorder n/a 1736 1737
disorder n/a 1751 1754
disorder n/a 1805 1808
disorder n/a 1810 1915
low_complexity n/a 1890 1895
Pfam OTCace_N 1924 2065
disorder n/a 2044 2045
Pfam OTCace 2071 2221
disorder n/a 2116 2117
disorder n/a 2129 2130

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P27708. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAALVLEDGS VLRGQPFGAA VSTAGEVVFQ TGMVGYPEAL TDPSYKAQIL
50
51
VLTYPLIGNY GIPPDEMDEF GLCKWFESSG IHVAALVVGE CCPTPSHWSA
100
101
TRTLHEWLQQ HGIPGLQGVD TRELTKKLRE QGSLLGKLVQ NGTEPSSLPF
150
151
LDPNARPLVP EVSIKTPRVF NTGGAPRILA LDCGLKYNQI RCLCQRGAEV
200
201
TVVPWDHALD SQEYEGLFLS NGPGDPASYP SVVSTLSRVL SEPNPRPVFG
250
251
ICLGHQLLAL AIGAKTYKMR YGNRGHNQPC LLVGSGRCFL TSQNHGFAVE
300
301
TDSLPADWAP LFTNANDGSN EGIVHNSLPF FSVQFHPEHQ AGPSDMELLF
350
351
DIFLETVKEA TAGNPGGQTV RERLTERLCP PGIPTPGSGL PPPRKVLILG
400
401
SGGLSIGQAG EFDYSGSQAI KALKEENIQT LLINPNIATV QTSQGLADKV
450
451
YFLPITPHYV TQVIRNERPD GVLLTFGGQT ALNCGVELTK AGVLARYGVR
500
501
VLGTPVETIE LTEDRRAFAA RMAEIGEHVA PSEAANSLEQ AQAAAERLGY
550
551
PVLVRAAFAL GGLGSGFASN REELSALVAP AFAHTSQVLV DKSLKGWKEI
600
601
EYEVVRDAYG NCVTVCNMEN LDPLGIHTGE SIVVAPSQTL NDREYQLLRQ
650
651
TAIKVTQHLG IVGECNVQYA LNPESEQYYI IEVNARLSRS SALASKATGY
700
701
PLAYVAAKLA LGIPLPELRN SVTGGTAAFE PSVDYCVVKI PRWDLSKFLR
750
751
VSTKIGSCMK SVGEVMGIGR SFEEAFQKAL RMVDENCVGF DHTVKPVSDM
800
801
ELETPTDKRI FVVAAALWAG YSVDRLYELT RIDRWFLHRM KRIIAHAQLL
850
851
EQHRGQPLPP DLLQQAKCLG FSDKQIALAV LSTELAVRKL RQELGICPAV
900
901
KQIDTVAAEW PAQTNYLYLT YWGTTHDLTF RTPHVLVLGS GVYRIGSSVE
950
951
FDWCAVGCIQ QLRKMGYKTI MVNYNPETVS TDYDMCDRLY FDEISFEVVM
1000
1001
DIYELENPEG VILSMGGQLP NNMAMALHRQ QCRVLGTSPE AIDSAENRFK
1050
1051
FSRLLDTIGI SQPQWRELSD LESARQFCQT VGYPCVVRPS YVLSGAAMNV
1100
1101
AYTDGDLERF LSSAAAVSKE HPVVISKFIQ EAKEIDVDAV ASDGVVAAIA
1150
1151
ISEHVENAGV HSGDATLVTP PQDITAKTLE RIKAIVHAVG QELQVTGPFN
1200
1201
LQLIAKDDQL KVIECNVRVS RSFPFVSKTL GVDLVALATR VIMGEEVEPV
1250
1251
GLMTGSGVVG VKVPQFSFSR LAGADVVLGV EMTSTGEVAG FGESRCEAYL
1300
1301
KAMLSTGFKI PKKNILLTIG SYKNKSELLP TVRLLESLGY SLYASLGTAD
1350
1351
FYTEHGVKVT AVDWHFEEAV DGECPPQRSI LEQLAEKNFE LVINLSMRGA
1400
1401
GGRRLSSFVT KGYRTRRLAA DFSVPLIIDI KCTKLFVEAL GQIGPAPPLK
1450
1451
VHVDCMTSQK LVRLPGLIDV HVHLREPGGT HKEDFASGTA AALAGGITMV
1500
1501
CAMPNTRPPI IDAPALALAQ KLAEAGARCD FALFLGASSE NAGTLGTVAG
1550
1551
SAAGLKLYLN ETFSELRLDS VVQWMEHFET WPSHLPIVAH AEQQTVAAVL
1600
1601
MVAQLTQRSV HICHVARKEE ILLIKAAKAR GLPVTCEVAP HHLFLSHDDL
1650
1651
ERLGPGKGEV RPELGSRQDV EALWENMAVI DCFASDHAPH TLEEKCGSRP
1700
1701
PPGFPGLETM LPLLLTAVSE GRLSLDDLLQ RLHHNPRRIF HLPPQEDTYV
1750
1751
EVDLEHEWTI PSHMPFSKAH WTPFEGQKVK GTVRRVVLRG EVAYIDGQVL
1800
1801
VPPGYGQDVR KWPQGAVPQL PPSAPATSEM TTTPERPRRG IPGLPDGRFH
1850
1851
LPPRIHRASD PGLPAEEPKE KSSRKVAEPE LMGTPDGTCY PPPPVPRQAS
1900
1901
PQNLGTPGLL HPQTSPLLHS LVGQHILSVQ QFTKDQMSHL FNVAHTLRMM
1950
1951
VQKERSLDIL KGKVMASMFY EVSTRTSSSF AAAMARLGGA VLSFSEATSS
2000
2001
VQKGESLADS VQTMSCYADV VVLRHPQPGA VELAAKHCRR PVINAGDGVG
2050
2051
EHPTQALLDI FTIREELGTV NGMTITMVGD LKHGRTVHSL ACLLTQYRVS
2100
2101
LRYVAPPSLR MPPTVRAFVA SRGTKQEEFE SIEEALPDTD VLYMTRIQKE
2150
2151
RFGSTQEYEA CFGQFILTPH IMTRAKKKMV VMHPMPRVNE ISVEVDSDPR
2200
2201
AAYFRQAENG MYIRMALLAT VLGRF                           
2225
 

Show the unformatted sequence.

Checksums:
CRC64:2AB8E8413E825A8F
MD5:4655b332cfefd50c5e861d8ad52a8e66

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Amidohydro_1 1462 - 1745 4BY3 A 1462 - 1745 Jmol OpenAstexViewer
4C6B A 1462 - 1745 Jmol OpenAstexViewer
4C6C A 1462 - 1745 Jmol OpenAstexViewer
4C6D A 1462 - 1745 Jmol OpenAstexViewer
4C6E A 1462 - 1745 Jmol OpenAstexViewer
4C6F A 1462 - 1745 Jmol OpenAstexViewer
4C6I A 1462 - 1745 Jmol OpenAstexViewer
4C6J A 1462 - 1745 Jmol OpenAstexViewer
4C6K A 1462 - 1745 Jmol OpenAstexViewer
4C6L A 1462 - 1745 Jmol OpenAstexViewer
4C6M A 1462 - 1745 Jmol OpenAstexViewer
4C6N A 1462 - 1745 Jmol OpenAstexViewer
4C6O A 1462 - 1745 Jmol OpenAstexViewer
4C6P A 1462 - 1745 Jmol OpenAstexViewer
4C6Q A 1462 - 1745 Jmol OpenAstexViewer
5YNZ A 1462 - 1745 Jmol OpenAstexViewer
6HFD A 1462 - 1745 Jmol OpenAstexViewer
6HFE A 1462 - 1745 Jmol OpenAstexViewer
6HFF A 1462 - 1745 Jmol OpenAstexViewer
6HFH A 1462 - 1745 Jmol OpenAstexViewer
6HFI A 1462 - 1745 Jmol OpenAstexViewer
6HFJ A 1462 - 1745 Jmol OpenAstexViewer
6HFK A 1462 - 1745 Jmol OpenAstexViewer
6HFL A 1462 - 1745 Jmol OpenAstexViewer
6HFN A 1462 - 1745 Jmol OpenAstexViewer
6HFP A 1462 - 1745 Jmol OpenAstexViewer
6HFQ A 1462 - 1745 Jmol OpenAstexViewer
6HFR A 1462 - 1745 Jmol OpenAstexViewer
6HFS A 1462 - 1745 Jmol OpenAstexViewer
6HFU A 1462 - 1745 Jmol OpenAstexViewer
6HG1 A 1462 - 1747 Jmol OpenAstexViewer
6HG2 A 1462 - 1745 Jmol OpenAstexViewer
6HG3 A 1462 - 1747 Jmol OpenAstexViewer
OTCace 2071 - 2221 5G1N A 2071 - 2221 Jmol OpenAstexViewer
B 2071 - 2221 Jmol OpenAstexViewer
C 2071 - 2221 Jmol OpenAstexViewer
D 2071 - 2221 Jmol OpenAstexViewer
E 2071 - 2221 Jmol OpenAstexViewer
F 2071 - 2221 Jmol OpenAstexViewer
5G1O A 2071 - 2221 Jmol OpenAstexViewer
B 2071 - 2221 Jmol OpenAstexViewer
C 2071 - 2221 Jmol OpenAstexViewer
D 2071 - 2221 Jmol OpenAstexViewer
E 2071 - 2221 Jmol OpenAstexViewer
F 2071 - 2221 Jmol OpenAstexViewer
5G1P A 2071 - 2221 Jmol OpenAstexViewer
B 2071 - 2221 Jmol OpenAstexViewer
C 2071 - 2221 Jmol OpenAstexViewer
D 2071 - 2221 Jmol OpenAstexViewer
E 2071 - 2221 Jmol OpenAstexViewer
F 2071 - 2221 Jmol OpenAstexViewer
OTCace_N 1924 - 2065 5G1N A 1924 - 2065 Jmol OpenAstexViewer
B 1924 - 2065 Jmol OpenAstexViewer
C 1924 - 2065 Jmol OpenAstexViewer
D 1924 - 2065 Jmol OpenAstexViewer
E 1924 - 2065 Jmol OpenAstexViewer
F 1924 - 2065 Jmol OpenAstexViewer
5G1O A 1924 - 2065 Jmol OpenAstexViewer
B 1924 - 2065 Jmol OpenAstexViewer
C 1924 - 2065 Jmol OpenAstexViewer
D 1924 - 2065 Jmol OpenAstexViewer
E 1924 - 2065 Jmol OpenAstexViewer
F 1924 - 2065 Jmol OpenAstexViewer
5G1P A 1924 - 2065 Jmol OpenAstexViewer
B 1924 - 2065 Jmol OpenAstexViewer
C 1924 - 2065 Jmol OpenAstexViewer
D 1924 - 2065 Jmol OpenAstexViewer
E 1924 - 2065 Jmol OpenAstexViewer
F 1924 - 2065 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.