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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DMB_HUMAN (P28068)

Summary

This is the summary of UniProt entry DMB_HUMAN (P28068).

Description: HLA class II histocompatibility antigen, DM beta chain
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 263 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 17
low_complexity n/a 4 19
Pfam MHC_II_beta 27 106
disorder n/a 116 122
Pfam C1-set 117 199
disorder n/a 158 162
transmembrane n/a 219 240

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P28068. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MITFLPLLLG LSLGCTGAGG FVAHVESTCL LDDAGTPKDF TYCISFNKDL
50
51
LTCWDPEENK MAPCEFGVLN SLANVLSQHL NQKDTLMQRL RNGLQNCATH
100
101
TQPFWGSLTN RTRPPSVQVA KTTPFNTREP VMLACYVWGF YPAEVTITWR
150
151
KNGKLVMPHS SAHKTAQPNG DWTYQTLSHL ALTPSYGDTY TCVVEHIGAP
200
201
EPILRDWTPG LSPMQTLKVS VSAVTLGLGL IIFSLGVISW RRAGHSSYTP
250
251
LPGSNYSEGW HIS                                        
263
 

Show the unformatted sequence.

Checksums:
CRC64:9B50F6CC22B3A4BA
MD5:9f70b36b3216b6f236bedcc2a706fd7f

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
C1-set 117 - 199 1HDM B 93 - 174 Jmol OpenAstexViewer
2BC4 B 99 - 181 Jmol OpenAstexViewer
D 99 - 181 Jmol OpenAstexViewer
4FQX D 99 - 181 Jmol OpenAstexViewer
4GBX D 99 - 181 Jmol OpenAstexViewer
4I0P B 99 - 181 Jmol OpenAstexViewer
F 99 - 181 Jmol OpenAstexViewer
MHC_II_beta 27 - 106 1HDM B 9 - 82 Jmol OpenAstexViewer
2BC4 B 9 - 88 Jmol OpenAstexViewer
D 9 - 88 Jmol OpenAstexViewer
4FQX D 9 - 88 Jmol OpenAstexViewer
4GBX D 9 - 88 Jmol OpenAstexViewer
4I0P B 9 - 88 Jmol OpenAstexViewer
F 9 - 88 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.