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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RBL1_HUMAN (P28749)

Summary

This is the summary of UniProt entry RBL1_HUMAN (P28749).

Description: Retinoblastoma-like protein 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1068 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
low_complexity n/a 8 20
Pfam DUF3452 77 212
Pfam RB_A 385 578
disorder n/a 604 605
disorder n/a 608 610
low_complexity n/a 609 618
disorder n/a 622 649
disorder n/a 653 663
disorder n/a 666 669
disorder n/a 671 676
disorder n/a 705 708
disorder n/a 713 714
disorder n/a 716 722
disorder n/a 770 777
Pfam RB_B 787 943
disorder n/a 865 866
disorder n/a 916 921
Pfam Rb_C 953 1053
disorder n/a 960 991
disorder n/a 998 1002
disorder n/a 1014 1023
disorder n/a 1025 1041
disorder n/a 1044 1050
disorder n/a 1057 1061
disorder n/a 1065 1068

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P28749. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MFEDKPHAEG AAVVAAAGEA LQALCQELNL DEGSAAEALD DFTAIRGNYS
50
51
LEGEVTHWLA CSLYVACRKS IIPTVGKGIM EGNCVSLTRI LRSAKLSLIQ
100
101
FFSKMKKWMD MSNLPQEFRE RIERLERNFE VSTVIFKKYE PIFLDIFQNP
150
151
YEEPPKLPRS RKQRRIPCSV KDLFNFCWTL FVYTKGNFRM IGDDLVNSYH
200
201
LLLCCLDLIF ANAIMCPNRQ DLLNPSFKGL PSDFHTADFT ASEEPPCIIA
250
251
VLCELHDGLL VEAKGIKEHY FKPYISKLFD RKILKGECLL DLSSFTDNSK
300
301
AVNKEYEEYV LTVGDFDERI FLGADAEEEI GTPRKFTRDT PLGKLTAQAN
350
351
VEYNLQQHFE KKRSFAPSTP LTGRRYLREK EAVITPVASA TQSVSRLQSI
400
401
VAGLKNAPSD QLINIFESCV RNPVENIMKI LKGIGETFCQ HYTQSTDEQP
450
451
GSHIDFAVNR LKLAEILYYK ILETVMVQET RRLHGMDMSV LLEQDIFHRS
500
501
LMACCLEIVL FAYSSPRTFP WIIEVLNLQP FYFYKVIEVV IRSEEGLSRD
550
551
MVKHLNSIEE QILESLAWSH DSALWEALQV SANKVPTCEE VIFPNNFETG
600
601
NGGNVQGHLP LMPMSPLMHP RVKEVRTDSG SLRRDMQPLS PISVHERYSS
650
651
PTAGSAKRRL FGEDPPKEML MDKIITEGTK LKIAPSSSIT AENVSILPGQ
700
701
TLLTMATAPV TGTTGHKVTI PLHGVANDAG EITLIPLSMN TNQESKVKSP
750
751
VSLTAHSLIG ASPKQTNLTK AQEVHSTGIN RPKRTGSLAL FYRKVYHLAS
800
801
VRLRDLCLKL DVSNELRRKI WTCFEFTLVH CPDLMKDRHL DQLLLCAFYI
850
851
MAKVTKEERT FQEIMKSYRN QPQANSHVYR SVLLKSIPRE VVAYNKNIND
900
901
DFEMIDCDLE DATKTPDCSS GPVKEERGDL IKFYNTIYVG RVKSFALKYD
950
951
LANQDHMMDA PPLSPFPHIK QQPGSPRRIS QQHSIYISPH KNGSGLTPRS
1000
1001
ALLYKFNGSP SKSLKDINNM IRQGEQRTKK RVIAIDSDAE SPAKRVCQEN
1050
1051
DDVLLKRLQD VVSERANH                                   
1068
 

Show the unformatted sequence.

Checksums:
CRC64:2BC4876EA04BDB31
MD5:c5f3769e2822252d544d865eafb8a155

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
RB_A 391 - 578 4YOO A 391 - 578 Show 3D Structure View in InterPro
4YOS A 391 - 578 Show 3D Structure View in InterPro
4YOZ A 391 - 578 Show 3D Structure View in InterPro
RB_B 787 - 943 4YOO A 787 - 943 Show 3D Structure View in InterPro
4YOS A 787 - 943 Show 3D Structure View in InterPro
4YOZ A 787 - 943 Show 3D Structure View in InterPro
Rb_C 1000 - 1028 5TUV C 1000 - 1028 Show 3D Structure View in InterPro
1001 - 1024 5TUV F 1001 - 1024 Show 3D Structure View in InterPro
961 - 968 4YOO A 958 - 965 Show 3D Structure View in InterPro
962 - 967 4YOS A 959 - 964 Show 3D Structure View in InterPro
4YOZ A 962 - 967 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;