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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: GRN_HUMAN (P28799)

Summary

This is the summary of UniProt entry GRN_HUMAN (P28799).

Description: Progranulin {ECO:0000303|PubMed:16862116}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 593 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 17
Pfam Granulin 72 113
Pfam Granulin 138 179
Pfam Granulin 220 261
Pfam Granulin 295 336
disorder n/a 346 349
disorder n/a 351 354
Pfam Granulin 377 417
disorder n/a 427 430
Pfam Granulin 455 496
Pfam Granulin 532 573

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P28799. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MWTLVSWVAL TAGLVAGTRC PDGQFCPVAC CLDPGGASYS CCRPLLDKWP
50
51
TTLSRHLGGP CQVDAHCSAG HSCIFTVSGT SSCCPFPEAV ACGDGHHCCP
100
101
RGFHCSADGR SCFQRSGNNS VGAIQCPDSQ FECPDFSTCC VMVDGSWGCC
150
151
PMPQASCCED RVHCCPHGAF CDLVHTRCIT PTGTHPLAKK LPAQRTNRAV
200
201
ALSSSVMCPD ARSRCPDGST CCELPSGKYG CCPMPNATCC SDHLHCCPQD
250
251
TVCDLIQSKC LSKENATTDL LTKLPAHTVG DVKCDMEVSC PDGYTCCRLQ
300
301
SGAWGCCPFT QAVCCEDHIH CCPAGFTCDT QKGTCEQGPH QVPWMEKAPA
350
351
HLSLPDPQAL KRDVPCDNVS SCPSSDTCCQ LTSGEWGCCP IPEAVCCSDH
400
401
QHCCPQGYTC VAEGQCQRGS EIVAGLEKMP ARRASLSHPR DIGCDQHTSC
450
451
PVGQTCCPSL GGSWACCQLP HAVCCEDRQH CCPAGYTCNV KARSCEKEVV
500
501
SAQPATFLAR SPHVGVKDVE CGEGHFCHDN QTCCRDNRQG WACCPYRQGV
550
551
CCADRRHCCP AGFRCAARGT KCLRREAPRW DAPLRDPALR QLL       
593
 

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Checksums:
CRC64:4E5947F1B4EDE619
MD5:337571304c4f77ac5f097ae87c5e47fe

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Granulin 138 - 154 2JYV A 16 - 32 Jmol OpenAstexViewer
295 - 311 1G26 A 15 - 31 Jmol OpenAstexViewer
295 - 336 2JYE A 17 - 58 Jmol OpenAstexViewer
377 - 417 2JYT A 14 - 54 Jmol OpenAstexViewer
2JYU A 14 - 54 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.