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59  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: AA2AR_HUMAN (P29274)

Summary

This is the summary of UniProt entry AA2AR_HUMAN (P29274).

Description: Adenosine receptor A2a
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 412 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
transmembrane n/a 6 32
Pfam 7tm_1 23 288
transmembrane n/a 44 66
transmembrane n/a 78 100
low_complexity n/a 97 108
transmembrane n/a 121 143
transmembrane n/a 178 202
low_complexity n/a 186 198
transmembrane n/a 235 258
transmembrane n/a 270 290
disorder n/a 345 353
disorder n/a 357 368
disorder n/a 371 382
disorder n/a 384 412

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P29274. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPIMGSSVYI TVELAIAVLA ILGNVLVCWA VWLNSNLQNV TNYFVVSLAA
50
51
ADIAVGVLAI PFAITISTGF CAACHGCLFI ACFVLVLTQS SIFSLLAIAI
100
101
DRYIAIRIPL RYNGLVTGTR AKGIIAICWV LSFAIGLTPM LGWNNCGQPK
150
151
EGKNHSQGCG EGQVACLFED VVPMNYMVYF NFFACVLVPL LLMLGVYLRI
200
201
FLAARRQLKQ MESQPLPGER ARSTLQKEVH AAKSLAIIVG LFALCWLPLH
250
251
IINCFTFFCP DCSHAPLWLM YLAIVLSHTN SVVNPFIYAY RIREFRQTFR
300
301
KIIRSHVLRQ QEPFKAAGTS ARVLAAHGSD GEQVSLRLNG HPPGVWANGS
350
351
APHPERRPNG YALGLVSGGS AQESQGNTGL PDVELLSHEL KGVCPEPPGL
400
401
DDPLAQDGAG VS                                         
412
 

Show the unformatted sequence.

Checksums:
CRC64:9438E9D64A6BE61B
MD5:7729b3238384b417c4d5cff9e8f6a4a1

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
7tm_1 23 - 288 2YDO A 23 - 288 Show 3D Structure View in InterPro
2YDV A 23 - 288 Show 3D Structure View in InterPro
3EML A 23 - 288 Show 3D Structure View in InterPro
3PWH A 23 - 288 Show 3D Structure View in InterPro
3QAK A 23 - 288 Show 3D Structure View in InterPro
3REY A 23 - 288 Show 3D Structure View in InterPro
3RFM A 23 - 288 Show 3D Structure View in InterPro
3UZA A 23 - 288 Show 3D Structure View in InterPro
3UZC A 23 - 288 Show 3D Structure View in InterPro
3VG9 A 23 - 288 Show 3D Structure View in InterPro
3VGA A 23 - 288 Show 3D Structure View in InterPro
4EIY A 23 - 288 Show 3D Structure View in InterPro
4UG2 A 23 - 288 Show 3D Structure View in InterPro
B 23 - 288 Show 3D Structure View in InterPro
4UHR A 23 - 288 Show 3D Structure View in InterPro
5G53 A 23 - 288 Show 3D Structure View in InterPro
B 23 - 288 Show 3D Structure View in InterPro
5IU4 A 23 - 288 Show 3D Structure View in InterPro
5IU7 A 23 - 288 Show 3D Structure View in InterPro
5IU8 A 23 - 288 Show 3D Structure View in InterPro
5IUA A 23 - 288 Show 3D Structure View in InterPro
5IUB A 23 - 288 Show 3D Structure View in InterPro
5JTB A 23 - 288 Show 3D Structure View in InterPro
5K2A A 23 - 288 Show 3D Structure View in InterPro
5K2B A 23 - 288 Show 3D Structure View in InterPro
5K2C A 23 - 288 Show 3D Structure View in InterPro
5K2D A 23 - 288 Show 3D Structure View in InterPro
5MZJ A 23 - 288 Show 3D Structure View in InterPro
5MZP A 23 - 288 Show 3D Structure View in InterPro
5N2R A 23 - 288 Show 3D Structure View in InterPro
5NLX A 32 - 393 Show 3D Structure View in InterPro
5NM2 A 23 - 288 Show 3D Structure View in InterPro
5NM4 A 32 - 393 Show 3D Structure View in InterPro
5OLG A 23 - 288 Show 3D Structure View in InterPro
5OLH A 23 - 288 Show 3D Structure View in InterPro
5OLO A 23 - 288 Show 3D Structure View in InterPro
5OLV A 23 - 288 Show 3D Structure View in InterPro
5OLZ A 23 - 288 Show 3D Structure View in InterPro
5OM1 A 23 - 288 Show 3D Structure View in InterPro
5OM4 A 23 - 288 Show 3D Structure View in InterPro
5UIG A 23 - 288 Show 3D Structure View in InterPro
5UVI A 23 - 288 Show 3D Structure View in InterPro
5VRA A 23 - 288 Show 3D Structure View in InterPro
5WF5 A 23 - 288 Show 3D Structure View in InterPro
5WF6 A 23 - 288 Show 3D Structure View in InterPro
6AQF A 23 - 288 Show 3D Structure View in InterPro
6GDG A 23 - 288 Show 3D Structure View in InterPro
6GT3 A 23 - 288 Show 3D Structure View in InterPro
6JZH A 23 - 288 Show 3D Structure View in InterPro
6LPJ A 23 - 288 Show 3D Structure View in InterPro
6LPK A 23 - 288 Show 3D Structure View in InterPro
6LPL A 23 - 288 Show 3D Structure View in InterPro
6MH8 A 23 - 288 Show 3D Structure View in InterPro
6PS7 A 23 - 288 Show 3D Structure View in InterPro
6S0L A 23 - 288 Show 3D Structure View in InterPro
6S0Q A 23 - 288 Show 3D Structure View in InterPro
6WQA A 23 - 288 Show 3D Structure View in InterPro
6ZDR A 23 - 288 Show 3D Structure View in InterPro
6ZDV A 23 - 288 Show 3D Structure View in InterPro
7ARO A 23 - 288 Show 3D Structure View in InterPro
7RM5 A 23 - 288 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;