Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
40  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: KDM5A_HUMAN (P29375)

Summary

This is the summary of UniProt entry KDM5A_HUMAN (P29375).

Description: Lysine-specific demethylase 5A
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1690 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
low_complexity n/a 12 24
Pfam JmjN 20 53
Pfam ARID 86 170
disorder n/a 191 230
disorder n/a 253 256
disorder n/a 259 276
Pfam PHD 295 343
Pfam JmjC 470 586
low_complexity n/a 638 651
Pfam zf-C5HC2 676 728
Pfam PLU-1 741 1072
disorder n/a 806 818
coiled_coil n/a 846 866
disorder n/a 857 872
coiled_coil n/a 938 958
low_complexity n/a 1091 1119
disorder n/a 1093 1095
disorder n/a 1108 1112
Pfam PHD 1163 1218
low_complexity n/a 1193 1202
low_complexity n/a 1269 1280
disorder n/a 1296 1297
disorder n/a 1299 1301
disorder n/a 1307 1309
low_complexity n/a 1324 1331
disorder n/a 1327 1357
low_complexity n/a 1337 1351
disorder n/a 1360 1362
disorder n/a 1366 1367
low_complexity n/a 1403 1414
disorder n/a 1407 1442
disorder n/a 1466 1471
disorder n/a 1477 1543
low_complexity n/a 1494 1513
low_complexity n/a 1525 1546
coiled_coil n/a 1541 1576
low_complexity n/a 1544 1578
disorder n/a 1549 1564
disorder n/a 1566 1577
disorder n/a 1594 1597
low_complexity n/a 1663 1674
disorder n/a 1669 1674
disorder n/a 1676 1679

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P29375. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAGVGPGGYA AEFVPPPECP VFEPSWEEFT DPLSFIGRIR PLAEKTGICK
50
51
IRPPKDWQPP FACEVKSFRF TPRVQRLNEL EAMTRVRLDF LDQLAKFWEL
100
101
QGSTLKIPVV ERKILDLYAL SKIVASKGGF EMVTKEKKWS KVGSRLGYLP
150
151
GKGTGSLLKS HYERILYPYE LFQSGVSLMG VQMPNLDLKE KVEPEVLSTD
200
201
TQTSPEPGTR MNILPKRTRR VKTQSESGDV SRNTELKKLQ IFGAGPKVVG
250
251
LAMGTKDKED EVTRRRKVTN RSDAFNMQMR QRKGTLSVNF VDLYVCMFCG
300
301
RGNNEDKLLL CDGCDDSYHT FCLIPPLPDV PKGDWRCPKC VAEECSKPRE
350
351
AFGFEQAVRE YTLQSFGEMA DNFKSDYFNM PVHMVPTELV EKEFWRLVSS
400
401
IEEDVIVEYG ADISSKDFGS GFPVKDGRRK ILPEEEEYAL SGWNLNNMPV
450
451
LEQSVLAHIN VDISGMKVPW LYVGMCFSSF CWHIEDHWSY SINYLHWGEP
500
501
KTWYGVPSHA AEQLEEVMRE LAPELFESQP DLLHQLVTIM NPNVLMEHGV
550
551
PVYRTNQCAG EFVVTFPRAY HSGFNQGYNF AEAVNFCTAD WLPIGRQCVN
600
601
HYRRLRRHCV FSHEELIFKM AADPECLDVG LAAMVCKELT LMTEEETRLR
650
651
ESVVQMGVLM SEEEVFELVP DDERQCSACR TTCFLSALTC SCNPERLVCL
700
701
YHPTDLCPCP MQKKCLRYRY PLEDLPSLLY GVKVRAQSYD TWVSRVTEAL
750
751
SANFNHKKDL IELRVMLEDA EDRKYPENDL FRKLRDAVKE AETCASVAQL
800
801
LLSKKQKHRQ SPDSGRTRTK LTVEELKAFV QQLFSLPCVI SQARQVKNLL
850
851
DDVEEFHERA QEAMMDETPD SSKLQMLIDM GSSLYVELPE LPRLKQELQQ
900
901
ARWLDEVRLT LSDPQQVTLD VMKKLIDSGV GLAPHHAVEK AMAELQELLT
950
951
VSERWEEKAK VCLQARPRHS VASLESIVNE AKNIPAFLPN VLSLKEALQK
1000
1001
AREWTAKVEA IQSGSNYAYL EQLESLSAKG RPIPVRLEAL PQVESQVAAA
1050
1051
RAWRERTGRT FLKKNSSHTL LQVLSPRTDI GVYGSGKNRR KKVKELIEKE
1100
1101
KEKDLDLEPL SDLEEGLEET RDTAMVVAVF KEREQKEIEA MHSLRAANLA
1150
1151
KMTMVDRIEE VKFCICRKTA SGFMLQCELC KDWFHNSCVP LPKSSSQKKG
1200
1201
SSWQAKEVKF LCPLCMRSRR PRLETILSLL VSLQKLPVRL PEGEALQCLT
1250
1251
ERAMSWQDRA RQALATDELS SALAKLSVLS QRMVEQAARE KTEKIISAEL
1300
1301
QKAAANPDLQ GHLPSFQQSA FNRVVSSVSS SPRQTMDYDD EETDSDEDIR
1350
1351
ETYGYDMKDT ASVKSSSSLE PNLFCDEEIP IKSEEVVTHM WTAPSFCAEH
1400
1401
AYSSASKSCS QGSSTPRKQP RKSPLVPRSL EPPVLELSPG AKAQLEELMM
1450
1451
VGDLLEVSLD ETQHIWRILQ ATHPPSEDRF LHIMEDDSME EKPLKVKGKD
1500
1501
SSEKKRKRKL EKVEQLFGEG KQKSKELKKM DKPRKKKLKL GADKSKELNK
1550
1551
LAKKLAKEEE RKKKKEKAAA AKVELVKEST EKKREKKVLD IPSKYDWSGA
1600
1601
EESDDENAVC AAQNCQRPCK DKVDWVQCDG GCDEWFHQVC VGVSPEMAEN
1650
1651
EDYICINCAK KQGPVSPGPA PPPSFIMSYK LPMEDLKETS           
1690
 

Show the unformatted sequence.

Checksums:
CRC64:FCF6DC22DEF001DF
MD5:14e5d9dcd5efea5fb00ad9cbb57868f6

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
ARID 86 - 170 2JXJ A 86 - 170 Show 3D Structure View in InterPro
5CEH A 86 - 170 Show 3D Structure View in InterPro
5K4L A 86 - 170 Show 3D Structure View in InterPro
B 86 - 170 Show 3D Structure View in InterPro
5V9P A 86 - 170 Show 3D Structure View in InterPro
5V9T A 86 - 170 Show 3D Structure View in InterPro
B 86 - 170 Show 3D Structure View in InterPro
JmjC 470 - 586 5CEH A 470 - 586 Show 3D Structure View in InterPro
5E6H A 470 - 586 Show 3D Structure View in InterPro
5ISL A 470 - 586 Show 3D Structure View in InterPro
5IVB A 470 - 586 Show 3D Structure View in InterPro
5IVC A 470 - 586 Show 3D Structure View in InterPro
5IVE A 470 - 586 Show 3D Structure View in InterPro
5IVF A 470 - 586 Show 3D Structure View in InterPro
5IVJ A 470 - 586 Show 3D Structure View in InterPro
5IVV A 470 - 586 Show 3D Structure View in InterPro
5IVY A 470 - 586 Show 3D Structure View in InterPro
5IW0 A 470 - 586 Show 3D Structure View in InterPro
5IWF A 470 - 586 Show 3D Structure View in InterPro
5K4L A 470 - 586 Show 3D Structure View in InterPro
B 470 - 586 Show 3D Structure View in InterPro
5V9P A 470 - 586 Show 3D Structure View in InterPro
5V9T A 470 - 586 Show 3D Structure View in InterPro
B 470 - 586 Show 3D Structure View in InterPro
6BGU A 470 - 586 Show 3D Structure View in InterPro
6BGV A 470 - 586 Show 3D Structure View in InterPro
6BGW A 470 - 586 Show 3D Structure View in InterPro
6BGX A 470 - 586 Show 3D Structure View in InterPro
6BGY A 470 - 586 Show 3D Structure View in InterPro
6BGZ A 470 - 586 Show 3D Structure View in InterPro
6BH0 A 470 - 586 Show 3D Structure View in InterPro
6BH1 A 470 - 586 Show 3D Structure View in InterPro
6BH2 A 470 - 586 Show 3D Structure View in InterPro
6BH3 A 470 - 586 Show 3D Structure View in InterPro
6BH4 A 470 - 586 Show 3D Structure View in InterPro
6BH5 A 470 - 586 Show 3D Structure View in InterPro
6DQ4 A 470 - 586 Show 3D Structure View in InterPro
6DQ5 A 470 - 586 Show 3D Structure View in InterPro
6DQ6 A 470 - 586 Show 3D Structure View in InterPro
6DQ7 A 470 - 586 Show 3D Structure View in InterPro
6DQ8 A 470 - 586 Show 3D Structure View in InterPro
6DQ9 A 470 - 586 Show 3D Structure View in InterPro
6DQA A 470 - 586 Show 3D Structure View in InterPro
6DQB A 470 - 586 Show 3D Structure View in InterPro
6DQC A 470 - 586 Show 3D Structure View in InterPro
6DQD A 470 - 586 Show 3D Structure View in InterPro
6DQE A 470 - 586 Show 3D Structure View in InterPro
6DQF A 470 - 586 Show 3D Structure View in InterPro
JmjN 20 - 53 5CEH A 20 - 53 Show 3D Structure View in InterPro
5E6H A 20 - 53 Show 3D Structure View in InterPro
5ISL A 20 - 53 Show 3D Structure View in InterPro
5IVB A 20 - 53 Show 3D Structure View in InterPro
5IVC A 20 - 53 Show 3D Structure View in InterPro
5IVE A 20 - 53 Show 3D Structure View in InterPro
5IVF A 20 - 53 Show 3D Structure View in InterPro
5IVJ A 20 - 53 Show 3D Structure View in InterPro
5IVV A 20 - 53 Show 3D Structure View in InterPro
5IVY A 20 - 53 Show 3D Structure View in InterPro
5IW0 A 20 - 53 Show 3D Structure View in InterPro
5IWF A 20 - 53 Show 3D Structure View in InterPro
5K4L A 20 - 53 Show 3D Structure View in InterPro
B 20 - 53 Show 3D Structure View in InterPro
5V9P A 20 - 53 Show 3D Structure View in InterPro
5V9T A 20 - 53 Show 3D Structure View in InterPro
B 20 - 53 Show 3D Structure View in InterPro
6BGU A 20 - 53 Show 3D Structure View in InterPro
6BGV A 20 - 53 Show 3D Structure View in InterPro
6BGW A 20 - 53 Show 3D Structure View in InterPro
6BGX A 20 - 53 Show 3D Structure View in InterPro
6BGY A 20 - 53 Show 3D Structure View in InterPro
6BGZ A 20 - 53 Show 3D Structure View in InterPro
6BH0 A 20 - 53 Show 3D Structure View in InterPro
6BH1 A 20 - 53 Show 3D Structure View in InterPro
6BH2 A 20 - 53 Show 3D Structure View in InterPro
6BH3 A 20 - 53 Show 3D Structure View in InterPro
6BH4 A 20 - 53 Show 3D Structure View in InterPro
6BH5 A 20 - 53 Show 3D Structure View in InterPro
6DQ4 A 20 - 53 Show 3D Structure View in InterPro
6DQ5 A 20 - 53 Show 3D Structure View in InterPro
6DQ6 A 20 - 53 Show 3D Structure View in InterPro
6DQ7 A 20 - 53 Show 3D Structure View in InterPro
6DQ8 A 20 - 53 Show 3D Structure View in InterPro
6DQ9 A 20 - 53 Show 3D Structure View in InterPro
6DQA A 20 - 53 Show 3D Structure View in InterPro
6DQB A 20 - 53 Show 3D Structure View in InterPro
6DQC A 20 - 53 Show 3D Structure View in InterPro
6DQD A 20 - 53 Show 3D Structure View in InterPro
6DQE A 20 - 53 Show 3D Structure View in InterPro
6DQF A 20 - 53 Show 3D Structure View in InterPro
PLU-1 741 - 785 5CEH A 741 - 785 Show 3D Structure View in InterPro
5K4L A 741 - 785 Show 3D Structure View in InterPro
B 741 - 785 Show 3D Structure View in InterPro
5V9P A 741 - 785 Show 3D Structure View in InterPro
5V9T A 741 - 785 Show 3D Structure View in InterPro
B 741 - 785 Show 3D Structure View in InterPro
zf-C5HC2 676 - 728 5CEH A 676 - 728 Show 3D Structure View in InterPro
5K4L A 676 - 728 Show 3D Structure View in InterPro
B 676 - 728 Show 3D Structure View in InterPro
5V9P A 676 - 728 Show 3D Structure View in InterPro
5V9T A 676 - 728 Show 3D Structure View in InterPro
B 676 - 728 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;