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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PML_HUMAN (P29590)

Summary

This is the summary of UniProt entry PML_HUMAN (P29590).

Description: Protein PML
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 882 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 47
low_complexity n/a 14 28
Pfam zf-B_box 124 166
coiled_coil n/a 233 253
Pfam DUF3583 240 570
disorder n/a 240 242
low_complexity n/a 279 294
disorder n/a 397 422
disorder n/a 427 431
disorder n/a 437 445
disorder n/a 456 457
disorder n/a 460 461
disorder n/a 463 546
disorder n/a 549 589
low_complexity n/a 559 571
low_complexity n/a 569 587
disorder n/a 591 600
disorder n/a 870 874
disorder n/a 876 878
disorder n/a 880 882

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P29590. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEPAPARSPR PQQDPARPQE PTMPPPETPS EGRQPSPSPS PTERAPASEE
50
51
EFQFLRCQQC QAEAKCPKLL PCLHTLCSGC LEASGMQCPI CQAPWPLGAD
100
101
TPALDNVFFE SLQRRLSVYR QIVDAQAVCT RCKESADFWC FECEQLLCAK
150
151
CFEAHQWFLK HEARPLAELR NQSVREFLDG TRKTNNIFCS NPNHRTPTLT
200
201
SIYCRGCSKP LCCSCALLDS SHSELKCDIS AEIQQRQEEL DAMTQALQEQ
250
251
DSAFGAVHAQ MHAAVGQLGR ARAETEELIR ERVRQVVAHV RAQERELLEA
300
301
VDARYQRDYE EMASRLGRLD AVLQRIRTGS ALVQRMKCYA SDQEVLDMHG
350
351
FLRQALCRLR QEEPQSLQAA VRTDGFDEFK VRLQDLSSCI TQGKDAAVSK
400
401
KASPEAASTP RDPIDVDLPE EAERVKAQVQ ALGLAEAQPM AVVQSVPGAH
450
451
PVPVYAFSIK GPSYGEDVSN TTTAQKRKCS QTQCPRKVIK MESEEGKEAR
500
501
LARSSPEQPR PSTSKAVSPP HLDGPPSPRS PVIGSEVFLP NSNHVASGAG
550
551
EAEERVVVIS SSEDSDAENS SSRELDDSSS ESSDLQLEGP STLRVLDENL
600
601
ADPQAEDRPL VFFDLKIDNE TQKISQLAAV NRESKFRVVI QPEAFFSIYS
650
651
KAVSLEVGLQ HFLSFLSSMR RPILACYKLW GPGLPNFFRA LEDINRLWEF
700
701
QEAISGFLAA LPLIRERVPG ASSFKLKNLA QTYLARNMSE RSAMAAVLAM
750
751
RDLCRLLEVS PGPQLAQHVY PFSSLQCFAS LQPLVQAAVL PRAEARLLAL
800
801
HNVSFMELLS AHRRDRQGGL KKYSRYLSLQ TTTLPPAQPA FNLQALGTYF
850
851
EGLLEGPALA RAEGVSTPLA GRGLAERASQ QS                   
882
 

Show the unformatted sequence.

Checksums:
CRC64:D50968A977E34287
MD5:085765eca087b15479a7d9554d7decaf

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
DUF3583 552 - 570 4WJN B 7 - 25 Jmol OpenAstexViewer
4WJO B 7 - 25 Jmol OpenAstexViewer
zf-B_box 124 - 166 2MVW A 124 - 166 Jmol OpenAstexViewer
B 124 - 166 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.