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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: AL4A1_HUMAN (P30038)

Summary

This is the summary of UniProt entry AL4A1_HUMAN (P30038).

Description: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial EC=1.2.1.88
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 563 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
low_complexity n/a 1 15
disorder n/a 51 52
Pfam Aldedh 74 547
disorder n/a 517 529
disorder n/a 533 535

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P30038. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MLLPAPALRR ALLSRPWTGA GLRWKHTSSL KVANEPVLAF TQGSPERDAL
50
51
QKALKDLKGR MEAIPCVVGD EEVWTSDVQY QVSPFNHGHK VAKFCYADKS
100
101
LLNKAIEAAL AARKEWDLKP IADRAQIFLK AADMLSGPRR AEILAKTMVG
150
151
QGKTVIQAEI DAAAELIDFF RFNAKYAVEL EGQQPISVPP STNSTVYRGL
200
201
EGFVAAISPF NFTAIGGNLA GAPALMGNVV LWKPSDTAML ASYAVYRILR
250
251
EAGLPPNIIQ FVPADGPLFG DTVTSSEHLC GINFTGSVPT FKHLWKQVAQ
300
301
NLDRFHTFPR LAGECGGKNF HFVHRSADVE SVVSGTLRSA FEYGGQKCSA
350
351
CSRLYVPHSL WPQIKGRLLE EHSRIKVGDP AEDFGTFFSA VIDAKSFARI
400
401
KKWLEHARSS PSLTILAGGK CDDSVGYFVE PCIVESKDPQ EPIMKEEIFG
450
451
PVLSVYVYPD DKYKETLQLV DSTTSYGLTG AVFSQDKDVV QEATKVLRNA
500
501
AGNFYINDKS TGSIVGQQPF GGARASGTND KPGGPHYILR WTSPQVIKET
550
551
HKPLGDWSYA YMQ                                        
563
 

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Checksums:
CRC64:4D964771B7DB5FFD
MD5:b13de10c9830482a237a7c8cc9b9b826

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Aldedh 74 - 547 3V9G A 74 - 547 Jmol OpenAstexViewer
B 74 - 547 Jmol OpenAstexViewer
C 74 - 547 Jmol OpenAstexViewer
D 74 - 547 Jmol OpenAstexViewer
3V9H A 74 - 547 Jmol OpenAstexViewer
B 74 - 547 Jmol OpenAstexViewer
C 74 - 547 Jmol OpenAstexViewer
D 74 - 547 Jmol OpenAstexViewer
3V9I A 74 - 547 Jmol OpenAstexViewer
B 74 - 547 Jmol OpenAstexViewer
C 74 - 547 Jmol OpenAstexViewer
D 74 - 547 Jmol OpenAstexViewer
4OE5 A 74 - 547 Jmol OpenAstexViewer
B 74 - 547 Jmol OpenAstexViewer
C 74 - 547 Jmol OpenAstexViewer
D 74 - 547 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.