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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: CD6_HUMAN (P30203)

Summary

This is the summary of UniProt entry CD6_HUMAN (P30203).

Description: T-cell differentiation antigen CD6
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 668 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 19
disorder n/a 15 42
Pfam SRCR 48 156
disorder n/a 94 116
low_complexity n/a 97 109
low_complexity n/a 115 127
Pfam SRCR 164 260
Pfam SRCR 268 361
transmembrane n/a 399 424
low_complexity n/a 400 423
disorder n/a 468 490
low_complexity n/a 476 484
disorder n/a 502 668
low_complexity n/a 559 567
low_complexity n/a 632 638
low_complexity n/a 654 663

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P30203. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MWLFFGITGL LTAALSGHPS PAPPDQLNTS SAESELWEPG ERLPVRLTNG
50
51
SSSCSGTVEV RLEASWEPAC GALWDSRAAE AVCRALGCGG AEAASQLAPP
100
101
TPELPPPPAA GNTSVAANAT LAGAPALLCS GAEWRLCEVV EHACRSDGRR
150
151
ARVTCAENRA LRLVDGGGAC AGRVEMLEHG EWGSVCDDTW DLEDAHVVCR
200
201
QLGCGWAVQA LPGLHFTPGR GPIHRDQVNC SGAEAYLWDC PGLPGQHYCG
250
251
HKEDAGAVCS EHQSWRLTGG ADRCEGQVEV HFRGVWNTVC DSEWYPSEAK
300
301
VLCQSLGCGT AVERPKGLPH SLSGRMYYSC NGEELTLSNC SWRFNNSNLC
350
351
SQSLAARVLC SASRSLHNLS TPEVPASVQT VTIESSVTVK IENKESRELM
400
401
LLIPSIVLGI LLLGSLIFIA FILLRIKGKY ALPVMVNHQH LPTTIPAGSN
450
451
SYQPVPITIP KEVFMLPIQV QAPPPEDSDS GSDSDYEHYD FSAQPPVALT
500
501
TFYNSQRHRV TDEEVQQSRF QMPPLEEGLE ELHASHIPTA NPGHCITDPP
550
551
SLGPQYHPRS NSESSTSSGE DYCNSPKSKL PPWNPQVFSS ERSSFLEQPP
600
601
NLELAGTQPA FSAGPPADDS SSTSSGEWYQ NFQPPPQPPS EEQFGCPGSP
650
651
SPQPDSTDND DYDDISAA                                   
668
 

Show the unformatted sequence.

Checksums:
CRC64:59E6790E77FFBC42
MD5:af734c065fd46520408c1d432359336e

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
SRCR 164 - 260 5A2E A 164 - 260 Jmol OpenAstexViewer
268 - 361 5A2E A 268 - 361 Jmol OpenAstexViewer
48 - 156 5A2E A 48 - 156 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.