Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PUR8_HUMAN (P30566)

Summary

This is the summary of UniProt entry PUR8_HUMAN (P30566).

Description: Adenylosuccinate lyase {ECO:0000303|PubMed:8404037}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 484 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 6
Pfam Lyase_1 24 313
coiled_coil n/a 62 82
low_complexity n/a 119 131
disorder n/a 286 291
Pfam ADSL_C 378 460

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P30566. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAGGDHGSP DSYRSPLASR YASPEMCFVF SDRYKFRTWR QLWLWLAEAE
50
51
QTLGLPITDE QIQEMKSNLE NIDFKMAAEE EKRLRHDVMA HVHTFGHCCP
100
101
KAAGIIHLGA TSCYVGDNTD LIILRNALDL LLPKLARVIS RLADFAKERA
150
151
SLPTLGFTHF QPAQLTTVGK RCCLWIQDLC MDLQNLKRVR DDLRFRGVKG
200
201
TTGTQASFLQ LFEGDDHKVE QLDKMVTEKA GFKRAFIITG QTYTRKVDIE
250
251
VLSVLASLGA SVHKICTDIR LLANLKEMEE PFEKQQIGSS AMPYKRNPMR
300
301
SERCCSLARH LMTLVMDPLQ TASVQWFERT LDDSANRRIC LAEAFLTADT
350
351
ILNTLQNISE GLVVYPKVIE RRIRQELPFM ATENIIMAMV KAGGSRQDCH
400
401
EKIRVLSQQA ASVVKQEGGD NDLIERIQVD AYFSPIHSQL DHLLDPSSFT
450
451
GRASQQVQRF LEEEVYPLLK PYESVMKVKA ELCL                 
484
 

Show the unformatted sequence.

Checksums:
CRC64:7AA3A0A2C681FD94
MD5:a57cba6314c62d5fb51b67c8f8148b10

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
ADSL_C 378 - 460 2J91 A 378 - 460 Jmol OpenAstexViewer
B 378 - 460 Jmol OpenAstexViewer
C 378 - 460 Jmol OpenAstexViewer
D 378 - 460 Jmol OpenAstexViewer
2VD6 A 378 - 460 Jmol OpenAstexViewer
B 378 - 460 Jmol OpenAstexViewer
C 378 - 460 Jmol OpenAstexViewer
D 378 - 460 Jmol OpenAstexViewer
4FFX A 378 - 460 Jmol OpenAstexViewer
B 378 - 460 Jmol OpenAstexViewer
C 378 - 460 Jmol OpenAstexViewer
D 378 - 460 Jmol OpenAstexViewer
4FLC A 378 - 460 Jmol OpenAstexViewer
B 378 - 460 Jmol OpenAstexViewer
C 378 - 460 Jmol OpenAstexViewer
D 378 - 460 Jmol OpenAstexViewer
Lyase_1 24 - 313 2J91 A 24 - 313 Jmol OpenAstexViewer
B 24 - 313 Jmol OpenAstexViewer
C 24 - 313 Jmol OpenAstexViewer
D 24 - 313 Jmol OpenAstexViewer
2VD6 A 24 - 313 Jmol OpenAstexViewer
B 24 - 313 Jmol OpenAstexViewer
C 24 - 313 Jmol OpenAstexViewer
D 24 - 313 Jmol OpenAstexViewer
4FFX A 24 - 313 Jmol OpenAstexViewer
B 24 - 313 Jmol OpenAstexViewer
C 24 - 313 Jmol OpenAstexViewer
D 24 - 313 Jmol OpenAstexViewer
4FLC A 24 - 313 Jmol OpenAstexViewer
B 24 - 313 Jmol OpenAstexViewer
C 24 - 313 Jmol OpenAstexViewer
D 24 - 313 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.