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9  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CLIP1_HUMAN (P30622)

Summary

This is the summary of UniProt entry CLIP1_HUMAN (P30622).

Description: CAP-Gly domain-containing linker protein 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1438 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 2 3
disorder n/a 15 17
disorder n/a 34 54
low_complexity n/a 37 49
Pfam CAP_GLY 60 124
disorder n/a 88 91
disorder n/a 93 94
disorder n/a 122 193
low_complexity n/a 150 167
disorder n/a 196 207
Pfam CAP_GLY 214 278
disorder n/a 283 284
disorder n/a 292 296
disorder n/a 300 304
low_complexity n/a 303 331
disorder n/a 307 314
disorder n/a 318 324
disorder n/a 327 335
disorder n/a 337 341
disorder n/a 347 348
coiled_coil n/a 350 377
disorder n/a 351 352
disorder n/a 354 355
disorder n/a 358 361
disorder n/a 364 366
disorder n/a 368 373
disorder n/a 375 376
disorder n/a 378 382
disorder n/a 386 394
disorder n/a 396 397
disorder n/a 399 401
disorder n/a 403 412
coiled_coil n/a 403 451
disorder n/a 424 426
disorder n/a 428 429
disorder n/a 442 443
disorder n/a 452 474
coiled_coil n/a 477 497
disorder n/a 497 500
coiled_coil n/a 512 532
disorder n/a 532 537
low_complexity n/a 544 559
disorder n/a 560 561
disorder n/a 563 567
disorder n/a 570 579
disorder n/a 584 586
disorder n/a 588 593
coiled_coil n/a 588 615
low_complexity n/a 595 609
disorder n/a 600 611
coiled_coil n/a 624 644
disorder n/a 642 644
coiled_coil n/a 660 817
disorder n/a 670 691
disorder n/a 713 716
disorder n/a 722 730
disorder n/a 777 781
disorder n/a 784 785
disorder n/a 787 795
disorder n/a 804 813
disorder n/a 815 823
coiled_coil n/a 832 873
disorder n/a 866 869
disorder n/a 871 886
coiled_coil n/a 881 936
disorder n/a 889 890
disorder n/a 892 897
disorder n/a 902 924
disorder n/a 929 953
coiled_coil n/a 944 1192
disorder n/a 955 962
disorder n/a 964 967
disorder n/a 974 1134
low_complexity n/a 984 1013
low_complexity n/a 1076 1090
low_complexity n/a 1125 1143
disorder n/a 1136 1146
disorder n/a 1148 1149
disorder n/a 1155 1162
low_complexity n/a 1160 1175
disorder n/a 1165 1170
disorder n/a 1172 1181
disorder n/a 1183 1208
coiled_coil n/a 1196 1216
disorder n/a 1216 1219
disorder n/a 1221 1223
coiled_coil n/a 1242 1269
disorder n/a 1253 1257
disorder n/a 1269 1271
coiled_coil n/a 1273 1307
low_complexity n/a 1279 1297
disorder n/a 1296 1321
coiled_coil n/a 1323 1350
disorder n/a 1340 1367
low_complexity n/a 1349 1360
low_complexity n/a 1362 1373
Pfam CLIP1_ZNF 1376 1393
disorder n/a 1393 1413
Pfam CLIP1_ZNF 1416 1432

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P30622. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSMLKPSGLK APTKILKPGS TALKTPTAVV APVEKTISSE KASSTPSSET
50
51
QEEFVDDFRV GERVWVNGNK PGFIQFLGET QFAPGQWAGI VLDEPIGKND
100
101
GSVAGVRYFQ CEPLKGIFTR PSKLTRKVQA EDEANGLQTT PASRATSPLC
150
151
TSTASMVSSS PSTPSNIPQK PSQPAAKEPS ATPPISNLTK TASESISNLS
200
201
EAGSIKKGER ELKIGDRVLV GGTKAGVVRF LGETDFAKGE WCGVELDEPL
250
251
GKNDGAVAGT RYFQCQPKYG LFAPVHKVTK IGFPSTTPAK AKANAVRRVM
300
301
ATTSASLKRS PSASSLSSMS SVASSVSSRP SRTGLLTETS SRYARKISGT
350
351
TALQEALKEK QQHIEQLLAE RDLERAEVAK ATSHVGEIEQ ELALARDGHD
400
401
QHVLELEAKM DQLRTMVEAA DREKVELLNQ LEEEKRKVED LQFRVEEESI
450
451
TKGDLEQKSQ ISEDPENTQT KLEHARIKEL EQSLLFEKTK ADKLQRELED
500
501
TRVATVSEKS RIMELEKDLA LRVQEVAELR RRLESNKPAG DVDMSLSLLQ
550
551
EISSLQEKLE VTRTDHQREI TSLKEHFGAR EETHQKEIKA LYTATEKLSK
600
601
ENESLKSKLE HANKENSDVI ALWKSKLETA IASHQQAMEE LKVSFSKGLG
650
651
TETAEFAELK TQIEKMRLDY QHEIENLQNQ QDSERAAHAK EMEALRAKLM
700
701
KVIKEKENSL EAIRSKLDKA EDQHLVEMED TLNKLQEAEI KVKELEVLQA
750
751
KCNEQTKVID NFTSQLKATE EKLLDLDALR KASSEGKSEM KKLRQQLEAA
800
801
EKQIKHLEIE KNAESSKASS ITRELQGREL KLTNLQENLS EVSQVKETLE
850
851
KELQILKEKF AEASEEAVSV QRSMQETVNK LHQKEEQFNM LSSDLEKLRE
900
901
NLADMEAKFR EKDEREEQLI KAKEKLENDI AEIMKMSGDN SSQLTKMNDE
950
951
LRLKERDVEE LQLKLTKANE NASFLQKSIE DMTVKAEQSQ QEAAKKHEEE
1000
1001
KKELERKLSD LEKKMETSHN QCQELKARYE RATSETKTKH EEILQNLQKT
1050
1051
LLDTEDKLKG AREENSGLLQ ELEELRKQAD KAKAAQTAED AMQIMEQMTK
1100
1101
EKTETLASLE DTKQTNAKLQ NELDTLKENN LKNVEELNKS KELLTVENQK
1150
1151
MEEFRKEIET LKQAAAQKSQ QLSALQEENV KLAEELGRSR DEVTSHQKLE
1200
1201
EERSVLNNQL LEMKKRESKF IKDADEEKAS LQKSISITSA LLTEKDAELE
1250
1251
KLRNEVTVLR GENASAKSLH SVVQTLESDK VKLELKVKNL ELQLKENKRQ
1300
1301
LSSSSGNTDT QADEDERAQE SQIDFLNSVI VDLQRKNQDL KMKVEMMSEA
1350
1351
ALNGNGDDLN NYDSDDQEKQ SKKKPRLFCD ICDCFDLHDT EDCPTQAQMS
1400
1401
EDPPHSTHHG SRGEERPYCE ICEMFGHWAT NCNDDETF             
1438
 

Show the unformatted sequence.

Checksums:
CRC64:A7F125F7A96DBDDB
MD5:94a36753a1517e19eeccffae8decf688

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
CAP_GLY 214 - 278 2CP6 A 41 - 105 Jmol OpenAstexViewer
2E3H A 214 - 278 Jmol OpenAstexViewer
2E4H A 214 - 278 Jmol OpenAstexViewer
60 - 124 2CP5 A 67 - 131 Jmol OpenAstexViewer
2E3I A 60 - 124 Jmol OpenAstexViewer
2QK0 A 33 - 97 Jmol OpenAstexViewer
3RDV A 60 - 124 Jmol OpenAstexViewer
B 60 - 124 Jmol OpenAstexViewer
C 60 - 124 Jmol OpenAstexViewer
D 60 - 124 Jmol OpenAstexViewer
CLIP1_ZNF 1416 - 1432 3E2U E 1405 - 1421 Jmol OpenAstexViewer
F 1405 - 1421 Jmol OpenAstexViewer
G 1405 - 1421 Jmol OpenAstexViewer
H 1405 - 1421 Jmol OpenAstexViewer
1417 - 1432 2HQH E 1406 - 1421 Jmol OpenAstexViewer
F 1406 - 1421 Jmol OpenAstexViewer
G 1406 - 1421 Jmol OpenAstexViewer
H 1406 - 1421 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.