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12  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RPB2_HUMAN (P30876)

Summary

This is the summary of UniProt entry RPB2_HUMAN (P30876).

Description: DNA-directed RNA polymerase II subunit RPB2 EC=2.7.7.6
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1174 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 16
low_complexity n/a 1 16
Pfam RNA_pol_Rpb2_1 38 442
disorder n/a 68 74
disorder n/a 99 108
disorder n/a 110 112
Pfam RNA_pol_Rpb2_2 201 394
low_complexity n/a 371 386
Pfam RNA_pol_Rpb2_3 468 532
Pfam RNA_pol_Rpb2_4 567 629
low_complexity n/a 604 614
Pfam RNA_pol_Rpb2_5 653 700
Pfam RNA_pol_Rpb2_6 707 1080
disorder n/a 721 724
disorder n/a 822 828
disorder n/a 877 884
disorder n/a 1066 1067
disorder n/a 1070 1072
disorder n/a 1080 1083
Pfam RNA_pol_Rpb2_7 1082 1174

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P30876. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MYDADEDMQY DEDDDEITPD LWQEACWIVI SSYFDEKGLV RQQLDSFDEF
50
51
IQMSVQRIVE DAPPIDLQAE AQHASGEVEE PPRYLLKFEQ IYLSKPTHWE
100
101
RDGAPSPMMP NEARLRNLTY SAPLYVDITK TVIKEGEEQL QTQHQKTFIG
150
151
KIPIMLRSTY CLLNGLTDRD LCELNECPLD PGGYFIINGS EKVLIAQEKM
200
201
ATNTVYVFAK KDSKYAYTGE CRSCLENSSR PTSTIWVSML ARGGQGAKKS
250
251
AIGQRIVATL PYIKQEVPII IVFRALGFVS DRDILEHIIY DFEDPEMMEM
300
301
VKPSLDEAFV IQEQNVALNF IGSRGAKPGV TKEKRIKYAK EVLQKEMLPH
350
351
VGVSDFCETK KAYFLGYMVH RLLLAALGRR ELDDRDHYGN KRLDLAGPLL
400
401
AFLFRGMFKN LLKEVRIYAQ KFIDRGKDFN LELAIKTRII SDGLKYSLAT
450
451
GNWGDQKKAH QARAGVSQVL NRLTFASTLS HLRRLNSPIG RDGKLAKPRQ
500
501
LHNTLWGMVC PAETPEGHAV GLVKNLALMA YISVGSQPSP ILEFLEEWSM
550
551
ENLEEISPAA IADATKIFVN GCWVGIHKDP EQLMNTLRKL RRQMDIIVSE
600
601
VSMIRDIRER EIRIYTDAGR ICRPLLIVEK QKLLLKKRHI DQLKEREYNN
650
651
YSWQDLVASG VVEYIDTLEE ETVMLAMTPD DLQEKEVAYC STYTHCEIHP
700
701
SMILGVCASI IPFPDHNQSP RNTYQSAMGK QAMGVYITNF HVRMDTLAHV
750
751
LYYPQKPLVT TRSMEYLRFR ELPAGINSIV AIASYTGYNQ EDSVIMNRSA
800
801
VDRGFFRSVF YRSYKEQESK KGFDQEEVFE KPTRETCQGM RHAIYDKLDD
850
851
DGLIAPGVRV SGDDVIIGKT VTLPENEDEL ESTNRRYTKR DCSTFLRTSE
900
901
TGIVDQVMVT LNQEGYKFCK IRVRSVRIPQ IGDKFASRHG QKGTCGIQYR
950
951
QEDMPFTCEG ITPDIIINPH AIPSRMTIGH LIECLQGKVS ANKGEIGDAT
1000
1001
PFNDAVNVQK ISNLLSDYGY HLRGNEVLYN GFTGRKITSQ IFIGPTYYQR
1050
1051
LKHMVDDKIH SRARGPIQIL NRQPMEGRSR DGGLRFGEME RDCQIAHGAA
1100
1101
QFLRERLFEA SDPYQVHVCN LCGIMAIANT RTHTYECRGC RNKTQISLVR
1150
1151
MPYACKLLFQ ELMSMSIAPR MMSV                            
1174
 

Show the unformatted sequence.

Checksums:
CRC64:32BEDF7F95E4DE10
MD5:42dca276e44eb561a7a8ed505c601b39

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
RNA_pol_Rpb2_1 38 - 442 5IY6 B 38 - 442 Show 3D Structure View in InterPro
5IY7 B 38 - 442 Show 3D Structure View in InterPro
5IY8 B 38 - 442 Show 3D Structure View in InterPro
5IY9 B 38 - 442 Show 3D Structure View in InterPro
5IYA B 38 - 442 Show 3D Structure View in InterPro
5IYB B 38 - 442 Show 3D Structure View in InterPro
5IYC B 38 - 442 Show 3D Structure View in InterPro
5IYD B 38 - 442 Show 3D Structure View in InterPro
6DRD B 38 - 442 Show 3D Structure View in InterPro
6O9L B 38 - 442 Show 3D Structure View in InterPro
6XRE B 38 - 442 Show 3D Structure View in InterPro
7LBM B 38 - 442 Show 3D Structure View in InterPro
RNA_pol_Rpb2_2 201 - 394 5IY6 B 201 - 394 Show 3D Structure View in InterPro
5IY7 B 201 - 394 Show 3D Structure View in InterPro
5IY8 B 201 - 394 Show 3D Structure View in InterPro
5IY9 B 201 - 394 Show 3D Structure View in InterPro
5IYA B 201 - 394 Show 3D Structure View in InterPro
5IYB B 201 - 394 Show 3D Structure View in InterPro
5IYC B 201 - 394 Show 3D Structure View in InterPro
5IYD B 201 - 394 Show 3D Structure View in InterPro
6DRD B 201 - 394 Show 3D Structure View in InterPro
6O9L B 201 - 394 Show 3D Structure View in InterPro
6XRE B 201 - 394 Show 3D Structure View in InterPro
7LBM B 201 - 394 Show 3D Structure View in InterPro
RNA_pol_Rpb2_3 468 - 532 5IY6 B 468 - 532 Show 3D Structure View in InterPro
5IY7 B 468 - 532 Show 3D Structure View in InterPro
5IY8 B 468 - 532 Show 3D Structure View in InterPro
5IY9 B 468 - 532 Show 3D Structure View in InterPro
5IYA B 468 - 532 Show 3D Structure View in InterPro
5IYB B 468 - 532 Show 3D Structure View in InterPro
5IYC B 468 - 532 Show 3D Structure View in InterPro
5IYD B 468 - 532 Show 3D Structure View in InterPro
6DRD B 468 - 532 Show 3D Structure View in InterPro
6O9L B 468 - 532 Show 3D Structure View in InterPro
6XRE B 468 - 532 Show 3D Structure View in InterPro
7LBM B 468 - 532 Show 3D Structure View in InterPro
RNA_pol_Rpb2_4 567 - 629 5IY6 B 567 - 629 Show 3D Structure View in InterPro
5IY7 B 567 - 629 Show 3D Structure View in InterPro
5IY8 B 567 - 629 Show 3D Structure View in InterPro
5IY9 B 567 - 629 Show 3D Structure View in InterPro
5IYA B 567 - 629 Show 3D Structure View in InterPro
5IYB B 567 - 629 Show 3D Structure View in InterPro
5IYC B 567 - 629 Show 3D Structure View in InterPro
5IYD B 567 - 629 Show 3D Structure View in InterPro
6DRD B 567 - 629 Show 3D Structure View in InterPro
6O9L B 567 - 629 Show 3D Structure View in InterPro
6XRE B 567 - 629 Show 3D Structure View in InterPro
7LBM B 567 - 629 Show 3D Structure View in InterPro
RNA_pol_Rpb2_5 653 - 700 5IY6 B 653 - 700 Show 3D Structure View in InterPro
5IY7 B 653 - 700 Show 3D Structure View in InterPro
5IY8 B 653 - 700 Show 3D Structure View in InterPro
5IY9 B 653 - 700 Show 3D Structure View in InterPro
5IYA B 653 - 700 Show 3D Structure View in InterPro
5IYB B 653 - 700 Show 3D Structure View in InterPro
5IYC B 653 - 700 Show 3D Structure View in InterPro
5IYD B 653 - 700 Show 3D Structure View in InterPro
6DRD B 653 - 700 Show 3D Structure View in InterPro
6O9L B 653 - 700 Show 3D Structure View in InterPro
6XRE B 653 - 700 Show 3D Structure View in InterPro
7LBM B 653 - 700 Show 3D Structure View in InterPro
RNA_pol_Rpb2_6 707 - 1059 6DRD B 707 - 1059 Show 3D Structure View in InterPro
707 - 1080 5IY6 B 707 - 1080 Show 3D Structure View in InterPro
5IY7 B 707 - 1080 Show 3D Structure View in InterPro
5IY8 B 707 - 1080 Show 3D Structure View in InterPro
5IY9 B 707 - 1080 Show 3D Structure View in InterPro
5IYA B 707 - 1080 Show 3D Structure View in InterPro
5IYB B 707 - 1080 Show 3D Structure View in InterPro
5IYC B 707 - 1080 Show 3D Structure View in InterPro
5IYD B 707 - 1080 Show 3D Structure View in InterPro
6O9L B 707 - 1080 Show 3D Structure View in InterPro
6XRE B 707 - 1080 Show 3D Structure View in InterPro
7LBM B 707 - 1080 Show 3D Structure View in InterPro
RNA_pol_Rpb2_7 1082 - 1165 6XRE B 1082 - 1165 Show 3D Structure View in InterPro
1082 - 1174 5IY6 B 1082 - 1174 Show 3D Structure View in InterPro
5IY7 B 1082 - 1174 Show 3D Structure View in InterPro
5IY8 B 1082 - 1174 Show 3D Structure View in InterPro
5IY9 B 1082 - 1174 Show 3D Structure View in InterPro
5IYA B 1082 - 1174 Show 3D Structure View in InterPro
5IYB B 1082 - 1174 Show 3D Structure View in InterPro
5IYC B 1082 - 1174 Show 3D Structure View in InterPro
5IYD B 1082 - 1174 Show 3D Structure View in InterPro
6O9L B 1082 - 1174 Show 3D Structure View in InterPro
7LBM B 1082 - 1174 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;