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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CPSM_HUMAN (P31327)

Summary

This is the summary of UniProt entry CPSM_HUMAN (P31327).

Description: Carbamoyl-phosphate synthase [ammonia], mitochondrial
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1500 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam CPSase_sm_chain 48 183
Pfam GATase 221 397
low_complexity n/a 426 436
Pfam CPSase_L_D2 546 750
low_complexity n/a 717 729
disorder n/a 838 839
Pfam CPSase_L_D3 841 921
Pfam CPSase_L_D2 1088 1291
Pfam MGS 1373 1465
disorder n/a 1408 1411

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P31327. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTRILTAFKV VRTLKTGFGF TNVTAHQKWK FSRPGIRLLS VKAQTAHIVL
50
51
EDGTKMKGYS FGHPSSVAGE VVFNTGLGGY PEAITDPAYK GQILTMANPI
100
101
IGNGGAPDTT ALDELGLSKY LESNGIKVSG LLVLDYSKDY NHWLATKSLG
150
151
QWLQEEKVPA IYGVDTRMLT KIIRDKGTML GKIEFEGQPV DFVDPNKQNL
200
201
IAEVSTKDVK VYGKGNPTKV VAVDCGIKNN VIRLLVKRGA EVHLVPWNHD
250
251
FTKMEYDGIL IAGGPGNPAL AEPLIQNVRK ILESDRKEPL FGISTGNLIT
300
301
GLAAGAKTYK MSMANRGQNQ PVLNITNKQA FITAQNHGYA LDNTLPAGWK
350
351
PLFVNVNDQT NEGIMHESKP FFAVQFHPEV TPGPIDTEYL FDSFFSLIKK
400
401
GKATTITSVL PKPALVASRV EVSKVLILGS GGLSIGQAGE FDYSGSQAVK
450
451
AMKEENVKTV LMNPNIASVQ TNEVGLKQAD TVYFLPITPQ FVTEVIKAEQ
500
501
PDGLILGMGG QTALNCGVEL FKRGVLKEYG VKVLGTSVES IMATEDRQLF
550
551
SDKLNEINEK IAPSFAVESI EDALKAADTI GYPVMIRSAY ALGGLGSGIC
600
601
PNRETLMDLS TKAFAMTNQI LVEKSVTGWK EIEYEVVRDA DDNCVTVCNM
650
651
ENVDAMGVHT GDSVVVAPAQ TLSNAEFQML RRTSINVVRH LGIVGECNIQ
700
701
FALHPTSMEY CIIEVNARLS RSSALASKAT GYPLAFIAAK IALGIPLPEI
750
751
KNVVSGKTSA CFEPSLDYMV TKIPRWDLDR FHGTSSRIGS SMKSVGEVMA
800
801
IGRTFEESFQ KALRMCHPSI EGFTPRLPMN KEWPSNLDLR KELSEPSSTR
850
851
IYAIAKAIDD NMSLDEIEKL TYIDKWFLYK MRDILNMEKT LKGLNSESMT
900
901
EETLKRAKEI GFSDKQISKC LGLTEAQTRE LRLKKNIHPW VKQIDTLAAE
950
951
YPSVTNYLYV TYNGQEHDVN FDDHGMMVLG CGPYHIGSSV EFDWCAVSSI
1000
1001
RTLRQLGKKT VVVNCNPETV STDFDECDKL YFEELSLERI LDIYHQEACG
1050
1051
GCIISVGGQI PNNLAVPLYK NGVKIMGTSP LQIDRAEDRS IFSAVLDELK
1100
1101
VAQAPWKAVN TLNEALEFAK SVDYPCLLRP SYVLSGSAMN VVFSEDEMKK
1150
1151
FLEEATRVSQ EHPVVLTKFV EGAREVEMDA VGKDGRVISH AISEHVEDAG
1200
1201
VHSGDATLML PTQTISQGAI EKVKDATRKI AKAFAISGPF NVQFLVKGND
1250
1251
VLVIECNLRA SRSFPFVSKT LGVDFIDVAT KVMIGENVDE KHLPTLDHPI
1300
1301
IPADYVAIKA PMFSWPRLRD ADPILRCEMA STGEVACFGE GIHTAFLKAM
1350
1351
LSTGFKIPQK GILIGIQQSF RPRFLGVAEQ LHNEGFKLFA TEATSDWLNA
1400
1401
NNVPATPVAW PSQEGQNPSL SSIRKLIRDG SIDLVINLPN NNTKFVHDNY
1450
1451
VIRRTAVDSG IPLLTNFQVT KLFAEAVQKS RKVDSKSLFH YRQYSAGKAA
1500
1501
                                                      
1500
 

Show the unformatted sequence.

Checksums:
CRC64:E53A22D77563961D
MD5:7426404c2bb9be24af08783109b77d25

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
CPSase_L_D2 1088 - 1291 5DOT A 1088 - 1291 Show 3D Structure View in InterPro
B 1088 - 1291 Show 3D Structure View in InterPro
5DOU A 1088 - 1291 Show 3D Structure View in InterPro
B 1088 - 1291 Show 3D Structure View in InterPro
C 1088 - 1291 Show 3D Structure View in InterPro
D 1088 - 1291 Show 3D Structure View in InterPro
6UEL A 1088 - 1291 Show 3D Structure View in InterPro
B 1088 - 1291 Show 3D Structure View in InterPro
546 - 750 5DOT A 546 - 750 Show 3D Structure View in InterPro
B 546 - 750 Show 3D Structure View in InterPro
5DOU A 546 - 750 Show 3D Structure View in InterPro
B 546 - 750 Show 3D Structure View in InterPro
C 546 - 750 Show 3D Structure View in InterPro
D 546 - 750 Show 3D Structure View in InterPro
6UEL A 546 - 750 Show 3D Structure View in InterPro
B 546 - 750 Show 3D Structure View in InterPro
CPSase_L_D3 841 - 921 5DOT A 841 - 921 Show 3D Structure View in InterPro
B 841 - 921 Show 3D Structure View in InterPro
5DOU A 841 - 921 Show 3D Structure View in InterPro
B 841 - 921 Show 3D Structure View in InterPro
C 841 - 921 Show 3D Structure View in InterPro
D 841 - 921 Show 3D Structure View in InterPro
6UEL A 841 - 921 Show 3D Structure View in InterPro
B 841 - 921 Show 3D Structure View in InterPro
CPSase_sm_chain 48 - 183 5DOT A 48 - 183 Show 3D Structure View in InterPro
B 48 - 183 Show 3D Structure View in InterPro
5DOU A 48 - 183 Show 3D Structure View in InterPro
B 48 - 183 Show 3D Structure View in InterPro
C 48 - 183 Show 3D Structure View in InterPro
D 48 - 183 Show 3D Structure View in InterPro
6UEL A 48 - 183 Show 3D Structure View in InterPro
B 48 - 183 Show 3D Structure View in InterPro
GATase 221 - 397 5DOT A 221 - 397 Show 3D Structure View in InterPro
B 221 - 397 Show 3D Structure View in InterPro
5DOU A 221 - 397 Show 3D Structure View in InterPro
B 221 - 397 Show 3D Structure View in InterPro
C 221 - 397 Show 3D Structure View in InterPro
D 221 - 397 Show 3D Structure View in InterPro
6UEL A 221 - 397 Show 3D Structure View in InterPro
B 221 - 397 Show 3D Structure View in InterPro
MGS 1373 - 1465 2YVQ A 1373 - 1465 Show 3D Structure View in InterPro
5DOT A 1373 - 1465 Show 3D Structure View in InterPro
B 1373 - 1465 Show 3D Structure View in InterPro
5DOU A 1373 - 1465 Show 3D Structure View in InterPro
B 1373 - 1465 Show 3D Structure View in InterPro
C 1373 - 1465 Show 3D Structure View in InterPro
D 1373 - 1465 Show 3D Structure View in InterPro
6UEL A 1373 - 1465 Show 3D Structure View in InterPro
B 1373 - 1465 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;