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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: GBRA5_HUMAN (P31644)

Summary

This is the summary of UniProt entry GBRA5_HUMAN (P31644).

Description: Gamma-aminobutyric acid receptor subunit alpha-5
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 462 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
transmembrane n/a 6 24
Pfam Neur_chan_LBD 49 257
transmembrane n/a 257 281
Pfam Neur_chan_memb 264 374
transmembrane n/a 322 345
low_complexity n/a 353 364
disorder n/a 380 410
low_complexity n/a 401 417
transmembrane n/a 431 448
disorder n/a 459 462

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P31644. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDNGMFSGFI MIKNLLLFCI SMNLSSHFGF SQMPTSSVKD ETNDNITIFT
50
51
RILDGLLDGY DNRLRPGLGE RITQVRTDIY VTSFGPVSDT EMEYTIDVFF
100
101
RQSWKDERLR FKGPMQRLPL NNLLASKIWT PDTFFHNGKK SIAHNMTTPN
150
151
KLLRLEDDGT LLYTMRLTIS AECPMQLEDF PMDAHACPLK FGSYAYPNSE
200
201
VVYVWTNGST KSVVVAEDGS RLNQYHLMGQ TVGTENISTS TGEYTIMTAH
250
251
FHLKRKIGYF VIQTYLPCIM TVILSQVSFW LNRESVPART VFGVTTVLTM
300
301
TTLSISARNS LPKVAYATAM DWFIAVCYAF VFSALIEFAT VNYFTKRGWA
350
351
WDGKKALEAA KIKKKREVIL NKSTNAFTTG KMSHPPNIPK EQTPAGTSNT
400
401
TSVSVKPSEE KTSESKKTYN SISKIDKMSR IVFPVLFGTF NLVYWATYLN
450
451
REPVIKGAAS PK                                         
462
 

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Checksums:
CRC64:260A8B554113AFF9
MD5:d7a62a7875571778d520f0031609a633

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Neur_chan_memb 264 - 346 5O8F A 233 - 315 Jmol OpenAstexViewer
B 233 - 315 Jmol OpenAstexViewer
C 233 - 315 Jmol OpenAstexViewer
D 233 - 315 Jmol OpenAstexViewer
E 233 - 315 Jmol OpenAstexViewer
5OJM A 233 - 315 Jmol OpenAstexViewer
B 233 - 315 Jmol OpenAstexViewer
C 233 - 315 Jmol OpenAstexViewer
D 233 - 315 Jmol OpenAstexViewer
E 233 - 315 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.