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17  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: AKT2_HUMAN (P31751)

Summary

This is the summary of UniProt entry AKT2_HUMAN (P31751).

Description: RAC-beta serine/threonine-protein kinase EC=2.7.11.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 481 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam PH 6 108
disorder n/a 39 43
disorder n/a 47 50
disorder n/a 60 61
disorder n/a 116 129
disorder n/a 133 137
disorder n/a 139 140
Pfam Pkinase 152 409
disorder n/a 394 397
Pfam Pkinase_C 430 475

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P31751. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNEVSVIKEG WLHKRGEYIK TWRPRYFLLK SDGSFIGYKE RPEAPDQTLP
50
51
PLNNFSVAEC QLMKTERPRP NTFVIRCLQW TTVIERTFHV DSPDEREEWM
100
101
RAIQMVANSL KQRAPGEDPM DYKCGSPSDS STTEEMEVAV SKARAKVTMN
150
151
DFDYLKLLGK GTFGKVILVR EKATGRYYAM KILRKEVIIA KDEVAHTVTE
200
201
SRVLQNTRHP FLTALKYAFQ THDRLCFVME YANGGELFFH LSRERVFTEE
250
251
RARFYGAEIV SALEYLHSRD VVYRDIKLEN LMLDKDGHIK ITDFGLCKEG
300
301
ISDGATMKTF CGTPEYLAPE VLEDNDYGRA VDWWGLGVVM YEMMCGRLPF
350
351
YNQDHERLFE LILMEEIRFP RTLSPEAKSL LAGLLKKDPK QRLGGGPSDA
400
401
KEVMEHRFFL SINWQDVVQK KLLPPFKPQV TSEVDTRYFD DEFTAQSITI
450
451
TPPDRYDSLG LLELDQRTHF PQFSYSASIR E                    
481
 

Show the unformatted sequence.

Checksums:
CRC64:B18C87A7246BFB24
MD5:1dd26f451aea463f58467576eff14899

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PH 6 - 108 1P6S A 6 - 108 Jmol OpenAstexViewer
Pkinase 152 - 409 1GZK A 152 - 409 Jmol OpenAstexViewer
1GZN A 152 - 409 Jmol OpenAstexViewer
1GZO A 152 - 409 Jmol OpenAstexViewer
1MRV A 152 - 409 Jmol OpenAstexViewer
1MRY A 152 - 409 Jmol OpenAstexViewer
1O6K A 152 - 409 Jmol OpenAstexViewer
1O6L A 152 - 409 Jmol OpenAstexViewer
2JDO A 152 - 409 Jmol OpenAstexViewer
2JDR A 152 - 409 Jmol OpenAstexViewer
2UW9 A 152 - 409 Jmol OpenAstexViewer
2X39 A 152 - 409 Jmol OpenAstexViewer
2XH5 A 152 - 409 Jmol OpenAstexViewer
3D0E A 152 - 409 Jmol OpenAstexViewer
B 152 - 409 Jmol OpenAstexViewer
3E87 A 152 - 409 Jmol OpenAstexViewer
B 152 - 409 Jmol OpenAstexViewer
3E88 A 152 - 409 Jmol OpenAstexViewer
B 152 - 409 Jmol OpenAstexViewer
3E8D A 152 - 409 Jmol OpenAstexViewer
B 152 - 409 Jmol OpenAstexViewer
Pkinase_C 430 - 440 1MRV A 430 - 440 Jmol OpenAstexViewer
1MRY A 430 - 440 Jmol OpenAstexViewer
430 - 441 1GZK A 430 - 441 Jmol OpenAstexViewer
430 - 442 1GZN A 430 - 442 Jmol OpenAstexViewer
1GZO A 430 - 442 Jmol OpenAstexViewer
430 - 475 1O6K A 430 - 475 Jmol OpenAstexViewer
1O6L A 430 - 475 Jmol OpenAstexViewer
2JDO A 430 - 475 Jmol OpenAstexViewer
2JDR A 430 - 475 Jmol OpenAstexViewer
2UW9 A 430 - 475 Jmol OpenAstexViewer
2X39 A 430 - 475 Jmol OpenAstexViewer
2XH5 A 430 - 475 Jmol OpenAstexViewer
3D0E A 430 - 475 Jmol OpenAstexViewer
B 430 - 475 Jmol OpenAstexViewer
3E87 A 430 - 475 Jmol OpenAstexViewer
B 430 - 475 Jmol OpenAstexViewer
3E88 A 430 - 475 Jmol OpenAstexViewer
B 430 - 475 Jmol OpenAstexViewer
3E8D A 430 - 475 Jmol OpenAstexViewer
B 430 - 475 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.