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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: 1433B_HUMAN (P31946)

Summary

This is the summary of UniProt entry 1433B_HUMAN (P31946).

Description: 14-3-3 protein beta/alpha
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 246 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam 14-3-3 11 231
disorder n/a 25 26
disorder n/a 29 34
disorder n/a 65 84
coiled_coil n/a 67 105
disorder n/a 141 143
disorder n/a 145 147
disorder n/a 155 157
disorder n/a 231 246

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P31946. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTMDKSELVQ KAKLAEQAER YDDMAAAMKA VTEQGHELSN EERNLLSVAY
50
51
KNVVGARRSS WRVISSIEQK TERNEKKQQM GKEYREKIEA ELQDICNDVL
100
101
ELLDKYLIPN ATQPESKVFY LKMKGDYFRY LSEVASGDNK QTTVSNSQQA
150
151
YQEAFEISKK EMQPTHPIRL GLALNFSVFY YEILNSPEKA CSLAKTAFDE
200
201
AIAELDTLNE ESYKDSTLIM QLLRDNLTLW TSENQGDEGD AGEGEN    
246
 

Show the unformatted sequence.

Checksums:
CRC64:6BE1A9BF97468017
MD5:c82f2efd57f939ee3c4e571708dd31a8

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
14-3-3 11 - 231 2BQ0 A 11 - 231 Jmol OpenAstexViewer
B 11 - 231 Jmol OpenAstexViewer
2C23 A 11 - 231 Jmol OpenAstexViewer
4DNK A 11 - 231 Jmol OpenAstexViewer
B 11 - 231 Jmol OpenAstexViewer
5N10 A 11 - 231 Jmol OpenAstexViewer
B 11 - 231 Jmol OpenAstexViewer
6BYK A 11 - 231 Jmol OpenAstexViewer
B 11 - 231 Jmol OpenAstexViewer
C 11 - 231 Jmol OpenAstexViewer
D 11 - 231 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.