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61  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TTK_HUMAN (P33981)

Summary

This is the summary of UniProt entry TTK_HUMAN (P33981).

Description: Dual specificity protein kinase TTK EC=2.7.12.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 857 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 3 4
disorder n/a 38 40
disorder n/a 51 54
coiled_coil n/a 177 200
low_complexity n/a 185 203
disorder n/a 222 230
disorder n/a 236 243
disorder n/a 251 259
disorder n/a 271 272
disorder n/a 306 312
disorder n/a 317 318
disorder n/a 320 327
disorder n/a 333 338
disorder n/a 341 342
disorder n/a 350 352
disorder n/a 361 362
disorder n/a 365 395
disorder n/a 398 400
disorder n/a 406 418
disorder n/a 424 432
Pfam Pkinase 525 791
disorder n/a 695 710
disorder n/a 797 799
low_complexity n/a 833 846
disorder n/a 836 857

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P33981. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MESEDLSGRE LTIDSIMNKV RDIKNKFKNE DLTDELSLNK ISADTTDNSG
50
51
TVNQIMMMAN NPEDWLSLLL KLEKNSVPLS DALLNKLIGR YSQAIEALPP
100
101
DKYGQNESFA RIQVRFAELK AIQEPDDARD YFQMARANCK KFAFVHISFA
150
151
QFELSQGNVK KSKQLLQKAV ERGAVPLEML EIALRNLNLQ KKQLLSEEEK
200
201
KNLSASTVLT AQESFSGSLG HLQNRNNSCD SRGQTTKARF LYGENMPPQD
250
251
AEIGYRNSLR QTNKTKQSCP FGRVPVNLLN SPDCDVKTDD SVVPCFMKRQ
300
301
TSRSECRDLV VPGSKPSGND SCELRNLKSV QNSHFKEPLV SDEKSSELII
350
351
TDSITLKNKT ESSLLAKLEE TKEYQEPEVP ESNQKQWQSK RKSECINQNP
400
401
AASSNHWQIP ELARKVNTEQ KHTTFEQPVF SVSKQSPPIS TSKWFDPKSI
450
451
CKTPSSNTLD DYMSCFRTPV VKNDFPPACQ LSTPYGQPAC FQQQQHQILA
500
501
TPLQNLQVLA SSSANECISV KGRIYSILKQ IGSGGSSKVF QVLNEKKQIY
550
551
AIKYVNLEEA DNQTLDSYRN EIAYLNKLQQ HSDKIIRLYD YEITDQYIYM
600
601
VMECGNIDLN SWLKKKKSID PWERKSYWKN MLEAVHTIHQ HGIVHSDLKP
650
651
ANFLIVDGML KLIDFGIANQ MQPDTTSVVK DSQVGTVNYM PPEAIKDMSS
700
701
SRENGKSKSK ISPKSDVWSL GCILYYMTYG KTPFQQIINQ ISKLHAIIDP
750
751
NHEIEFPDIP EKDLQDVLKC CLKRDPKQRI SIPELLAHPY VQIQTHPVNQ
800
801
MAKGTTEEMK YVLGQLVGLN SPNSILKAAK TLYEHYSGGE SHNSSSSKTF
850
851
EKKRGKK                                               
857
 

Show the unformatted sequence.

Checksums:
CRC64:51F40A3CD1677AC5
MD5:37651753ac367085eee54832cb277f81

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase 525 - 753 5EI8 A 525 - 753 Jmol OpenAstexViewer
525 - 791 2X9E A 525 - 791 Jmol OpenAstexViewer
2ZMC A 525 - 791 Jmol OpenAstexViewer
2ZMD A 525 - 791 Jmol OpenAstexViewer
3CEK A 525 - 791 Jmol OpenAstexViewer
3DBQ A 525 - 791 Jmol OpenAstexViewer
3GFW A 525 - 791 Jmol OpenAstexViewer
3H9F A 525 - 791 Jmol OpenAstexViewer
3HMN A 525 - 791 Jmol OpenAstexViewer
3HMO A 525 - 791 Jmol OpenAstexViewer
3HMP A 525 - 791 Jmol OpenAstexViewer
3VQU A 525 - 791 Jmol OpenAstexViewer
3W1F A 525 - 791 Jmol OpenAstexViewer
3WYX A 525 - 791 Jmol OpenAstexViewer
3WYY A 525 - 791 Jmol OpenAstexViewer
3WZJ A 525 - 791 Jmol OpenAstexViewer
3WZK A 525 - 791 Jmol OpenAstexViewer
4BHZ A 525 - 791 Jmol OpenAstexViewer
4BI0 A 525 - 791 Jmol OpenAstexViewer
4BI1 A 525 - 791 Jmol OpenAstexViewer
4BI2 A 525 - 791 Jmol OpenAstexViewer
4C4E A 525 - 791 Jmol OpenAstexViewer
4C4F A 525 - 791 Jmol OpenAstexViewer
4C4G A 525 - 791 Jmol OpenAstexViewer
4C4H A 525 - 791 Jmol OpenAstexViewer
4C4I A 525 - 791 Jmol OpenAstexViewer
4C4J A 525 - 791 Jmol OpenAstexViewer
4CV8 A 525 - 791 Jmol OpenAstexViewer
4CV9 A 525 - 791 Jmol OpenAstexViewer
4CVA A 525 - 791 Jmol OpenAstexViewer
4D2S A 525 - 791 Jmol OpenAstexViewer
4JS8 A 525 - 791 Jmol OpenAstexViewer
4JT3 A 525 - 791 Jmol OpenAstexViewer
4O6L A 525 - 791 Jmol OpenAstexViewer
B 525 - 791 Jmol OpenAstexViewer
4ZEG A 525 - 791 Jmol OpenAstexViewer
5AP0 A 525 - 791 Jmol OpenAstexViewer
5AP1 A 525 - 791 Jmol OpenAstexViewer
5AP2 A 525 - 791 Jmol OpenAstexViewer
5AP3 A 525 - 791 Jmol OpenAstexViewer
5AP4 A 525 - 791 Jmol OpenAstexViewer
5AP5 A 525 - 791 Jmol OpenAstexViewer
5AP6 A 525 - 791 Jmol OpenAstexViewer
5AP7 A 525 - 791 Jmol OpenAstexViewer
5EH0 A 525 - 791 Jmol OpenAstexViewer
5EHL A 525 - 791 Jmol OpenAstexViewer
5EHO A 525 - 791 Jmol OpenAstexViewer
5EHY A 525 - 791 Jmol OpenAstexViewer
5EI2 A 525 - 791 Jmol OpenAstexViewer
5EI6 A 525 - 791 Jmol OpenAstexViewer
5LJJ A 525 - 791 Jmol OpenAstexViewer
5MRB A 525 - 791 Jmol OpenAstexViewer
5N7V A 525 - 791 Jmol OpenAstexViewer
5N84 A 525 - 791 Jmol OpenAstexViewer
5N87 A 525 - 791 Jmol OpenAstexViewer
5N93 A 525 - 791 Jmol OpenAstexViewer
5N9S A 525 - 791 Jmol OpenAstexViewer
5NA0 A 525 - 791 Jmol OpenAstexViewer
5NAD A 525 - 791 Jmol OpenAstexViewer
5NTT A 525 - 791 Jmol OpenAstexViewer
5O91 A 525 - 791 Jmol OpenAstexViewer
6B4W A 525 - 791 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.