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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: GLYC_HUMAN (P34896)

Summary

This is the summary of UniProt entry GLYC_HUMAN (P34896).

Description: Serine hydroxymethyltransferase, cytosolic
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 483 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 2
Pfam SHMT 26 425
low_complexity n/a 248 257
disorder n/a 395 396

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P34896. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTMPVNGAHK DADLWSSHDK MLAQPLKDSD VEVYNIIKKE SNRQRVGLEL
50
51
IASENFASRA VLEALGSCLN NKYSEGYPGQ RYYGGTEFID ELETLCQKRA
100
101
LQAYKLDPQC WGVNVQPYSG SPANFAVYTA LVEPHGRIMG LDLPDGGHLT
150
151
HGFMTDKKKI SATSIFFESM PYKVNPDTGY INYDQLEENA RLFHPKLIIA
200
201
GTSCYSRNLE YARLRKIADE NGAYLMADMA HISGLVAAGV VPSPFEHCHV
250
251
VTTTTHKTLR GCRAGMIFYR KGVKSVDPKT GKEILYNLES LINSAVFPGL
300
301
QGGPHNHAIA GVAVALKQAM TLEFKVYQHQ VVANCRALSE ALTELGYKIV
350
351
TGGSDNHLIL VDLRSKGTDG GRAEKVLEAC SIACNKNTCP GDRSALRPSG
400
401
LRLGTPALTS RGLLEKDFQK VAHFIHRGIE LTLQIQSDTG VRATLKEFKE
450
451
RLAGDKYQAA VQALREEVES FASLFPLPGL PDF                  
483
 

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Checksums:
CRC64:6CDD6CA06D017C19
MD5:471ae0938520553823fa7f496fcb4014

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
SHMT 26 - 425 1BJ4 A 26 - 425 Jmol OpenAstexViewer
6FL5 A 26 - 425 Jmol OpenAstexViewer
D 26 - 425 Jmol OpenAstexViewer
G 26 - 425 Jmol OpenAstexViewer
J 26 - 425 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.