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27  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SFTPD_HUMAN (P35247)

Summary

This is the summary of UniProt entry SFTPD_HUMAN (P35247).

Description: Pulmonary surfactant-associated protein D
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 375 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 21
low_complexity n/a 2 12
disorder n/a 21 25
disorder n/a 34 35
disorder n/a 37 233
Pfam Collagen 42 105
low_complexity n/a 48 67
low_complexity n/a 64 86
low_complexity n/a 96 122
low_complexity n/a 124 151
Pfam Collagen 163 224
Pfam Surfac_D-trimer 224 269
coiled_coil n/a 224 244
Pfam Lectin_C 271 375
disorder n/a 291 292
disorder n/a 335 340
disorder n/a 345 352

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P35247. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MLLFLLSALV LLTQPLGYLE AEMKTYSHRT MPSACTLVMC SSVESGLPGR
50
51
DGRDGREGPR GEKGDPGLPG AAGQAGMPGQ AGPVGPKGDN GSVGEPGPKG
100
101
DTGPSGPPGP PGVPGPAGRE GPLGKQGNIG PQGKPGPKGE AGPKGEVGAP
150
151
GMQGSAGARG LAGPKGERGV PGERGVPGNT GAAGSAGAMG PQGSPGARGP
200
201
PGLKGDKGIP GDKGAKGESG LPDVASLRQQ VEALQGQVQH LQAAFSQYKK
250
251
VELFPNGQSV GEKIFKTAGF VKPFTEAQLL CTQAGGQLAS PRSAAENAAL
300
301
QQLVVAKNEA AFLSMTDSKT EGKFTYPTGE SLVYSNWAPG EPNDDGGSED
350
351
CVEIFTNGKW NDRACGEKRL VVCEF                           
375
 

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Checksums:
CRC64:298917699FC40F6A
MD5:8baf7ce9f4b8b9ac6882ff80348c772b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Collagen 220 - 224 1M7L A 1 - 5 NGL View in InterPro
B 41 - 45 NGL View in InterPro
C 81 - 85 NGL View in InterPro
223 - 224 2RIC A 203 - 204 NGL View in InterPro
C 203 - 204 NGL View in InterPro
3DBZ B 203 - 204 NGL View in InterPro
5OXS B 203 - 204 NGL View in InterPro
C 203 - 204 NGL View in InterPro
Lectin_C 271 - 375 1B08 A 251 - 355 NGL View in InterPro
B 1251 - 1355 NGL View in InterPro
C 2251 - 2355 NGL View in InterPro
1PW9 A 251 - 355 NGL View in InterPro
B 251 - 355 NGL View in InterPro
C 251 - 355 NGL View in InterPro
1PWB A 251 - 355 NGL View in InterPro
B 251 - 355 NGL View in InterPro
C 251 - 355 NGL View in InterPro
2GGU A 251 - 355 NGL View in InterPro
B 251 - 355 NGL View in InterPro
C 251 - 355 NGL View in InterPro
2GGX A 251 - 355 NGL View in InterPro
B 251 - 355 NGL View in InterPro
C 251 - 355 NGL View in InterPro
2ORJ A 251 - 355 NGL View in InterPro
B 251 - 355 NGL View in InterPro
C 251 - 355 NGL View in InterPro
2ORK A 251 - 355 NGL View in InterPro
B 251 - 355 NGL View in InterPro
C 251 - 355 NGL View in InterPro
2OS9 A 251 - 355 NGL View in InterPro
B 251 - 355 NGL View in InterPro
C 251 - 355 NGL View in InterPro
2RIA A 251 - 355 NGL View in InterPro
B 251 - 355 NGL View in InterPro
C 251 - 355 NGL View in InterPro
2RIB A 251 - 355 NGL View in InterPro
B 251 - 355 NGL View in InterPro
C 251 - 355 NGL View in InterPro
2RIC A 251 - 355 NGL View in InterPro
B 251 - 355 NGL View in InterPro
C 251 - 355 NGL View in InterPro
2RID A 251 - 355 NGL View in InterPro
B 251 - 355 NGL View in InterPro
C 251 - 355 NGL View in InterPro
2RIE A 251 - 355 NGL View in InterPro
B 251 - 355 NGL View in InterPro
C 251 - 355 NGL View in InterPro
3DBZ A 251 - 355 NGL View in InterPro
B 251 - 355 NGL View in InterPro
C 251 - 355 NGL View in InterPro
3G81 A 251 - 355 NGL View in InterPro
B 251 - 355 NGL View in InterPro
C 251 - 355 NGL View in InterPro
3G83 A 251 - 355 NGL View in InterPro
B 251 - 355 NGL View in InterPro
C 251 - 355 NGL View in InterPro
3G84 A 251 - 355 NGL View in InterPro
B 251 - 355 NGL View in InterPro
C 251 - 355 NGL View in InterPro
3IKN A 251 - 355 NGL View in InterPro
B 251 - 355 NGL View in InterPro
C 251 - 355 NGL View in InterPro
3IKP A 251 - 355 NGL View in InterPro
B 251 - 355 NGL View in InterPro
C 251 - 355 NGL View in InterPro
3IKQ A 251 - 355 NGL View in InterPro
B 251 - 355 NGL View in InterPro
C 251 - 355 NGL View in InterPro
3IKR A 251 - 355 NGL View in InterPro
B 251 - 355 NGL View in InterPro
C 251 - 355 NGL View in InterPro
4E52 A 251 - 355 NGL View in InterPro
B 251 - 355 NGL View in InterPro
C 251 - 355 NGL View in InterPro
4M17 A 251 - 355 NGL View in InterPro
B 251 - 355 NGL View in InterPro
C 251 - 355 NGL View in InterPro
D 251 - 355 NGL View in InterPro
E 251 - 355 NGL View in InterPro
F 251 - 355 NGL View in InterPro
G 251 - 355 NGL View in InterPro
H 251 - 355 NGL View in InterPro
I 251 - 355 NGL View in InterPro
J 251 - 355 NGL View in InterPro
K 251 - 355 NGL View in InterPro
L 251 - 355 NGL View in InterPro
4M18 A 251 - 355 NGL View in InterPro
B 251 - 355 NGL View in InterPro
C 251 - 355 NGL View in InterPro
D 251 - 355 NGL View in InterPro
E 251 - 355 NGL View in InterPro
F 251 - 355 NGL View in InterPro
G 251 - 355 NGL View in InterPro
H 251 - 355 NGL View in InterPro
I 251 - 355 NGL View in InterPro
J 251 - 355 NGL View in InterPro
K 251 - 355 NGL View in InterPro
L 251 - 355 NGL View in InterPro
5OXR A 251 - 355 NGL View in InterPro
B 251 - 355 NGL View in InterPro
C 251 - 355 NGL View in InterPro
5OXS A 251 - 355 NGL View in InterPro
B 251 - 355 NGL View in InterPro
C 251 - 355 NGL View in InterPro
Surfac_D-trimer 224 - 257 1M7L A 5 - 38 NGL View in InterPro
B 45 - 78 NGL View in InterPro
C 85 - 118 NGL View in InterPro
224 - 269 1B08 A 204 - 249 NGL View in InterPro
2RIB B 204 - 249 NGL View in InterPro
2RIC A 204 - 249 NGL View in InterPro
B 204 - 249 NGL View in InterPro
C 204 - 249 NGL View in InterPro
3DBZ A 204 - 249 NGL View in InterPro
B 204 - 249 NGL View in InterPro
3IKN A 204 - 249 NGL View in InterPro
B 204 - 249 NGL View in InterPro
C 204 - 249 NGL View in InterPro
3IKP B 204 - 249 NGL View in InterPro
3IKR A 204 - 249 NGL View in InterPro
C 204 - 249 NGL View in InterPro
4E52 A 204 - 249 NGL View in InterPro
B 204 - 249 NGL View in InterPro
C 204 - 249 NGL View in InterPro
5OXR B 204 - 249 NGL View in InterPro
5OXS A 204 - 249 NGL View in InterPro
B 204 - 249 NGL View in InterPro
C 204 - 249 NGL View in InterPro
225 - 269 1B08 B 1205 - 1249 NGL View in InterPro
1PW9 A 205 - 249 NGL View in InterPro
B 205 - 249 NGL View in InterPro
1PWB A 205 - 249 NGL View in InterPro
B 205 - 249 NGL View in InterPro
2GGU A 205 - 249 NGL View in InterPro
B 205 - 249 NGL View in InterPro
C 205 - 249 NGL View in InterPro
2GGX A 205 - 249 NGL View in InterPro
B 205 - 249 NGL View in InterPro
C 205 - 249 NGL View in InterPro
2ORJ A 205 - 249 NGL View in InterPro
B 205 - 249 NGL View in InterPro
C 205 - 249 NGL View in InterPro
2ORK A 205 - 249 NGL View in InterPro
B 205 - 249 NGL View in InterPro
2OS9 A 205 - 249 NGL View in InterPro
B 205 - 249 NGL View in InterPro
2RID B 205 - 249 NGL View in InterPro
3G81 A 205 - 249 NGL View in InterPro
B 205 - 249 NGL View in InterPro
3G83 A 205 - 249 NGL View in InterPro
B 205 - 249 NGL View in InterPro
3G84 A 205 - 249 NGL View in InterPro
B 205 - 249 NGL View in InterPro
C 205 - 249 NGL View in InterPro
3IKP A 205 - 249 NGL View in InterPro
3IKR B 205 - 249 NGL View in InterPro
5OXR A 205 - 249 NGL View in InterPro
C 205 - 249 NGL View in InterPro
226 - 269 1PW9 C 206 - 249 NGL View in InterPro
1PWB C 206 - 249 NGL View in InterPro
2ORK C 206 - 249 NGL View in InterPro
2OS9 C 206 - 249 NGL View in InterPro
2RIB A 206 - 249 NGL View in InterPro
C 206 - 249 NGL View in InterPro
3DBZ C 206 - 249 NGL View in InterPro
3G81 C 206 - 249 NGL View in InterPro
3G83 C 206 - 249 NGL View in InterPro
3IKP C 206 - 249 NGL View in InterPro
227 - 269 2RID C 207 - 249 NGL View in InterPro
228 - 269 1B08 C 2208 - 2249 NGL View in InterPro
2RIE B 208 - 249 NGL View in InterPro
229 - 269 2RID A 209 - 249 NGL View in InterPro
230 - 269 2RIA A 210 - 249 NGL View in InterPro
B 210 - 249 NGL View in InterPro
C 210 - 249 NGL View in InterPro
3IKQ A 210 - 249 NGL View in InterPro
B 210 - 249 NGL View in InterPro
231 - 269 2RIE A 211 - 249 NGL View in InterPro
C 211 - 249 NGL View in InterPro
3IKQ C 211 - 249 NGL View in InterPro
4M18 D 211 - 249 NGL View in InterPro
E 211 - 249 NGL View in InterPro
F 211 - 249 NGL View in InterPro
H 211 - 249 NGL View in InterPro
232 - 269 4M17 C 212 - 249 NGL View in InterPro
4M18 C 212 - 249 NGL View in InterPro
233 - 269 4M18 G 213 - 249 NGL View in InterPro
K 213 - 249 NGL View in InterPro
L 213 - 249 NGL View in InterPro
234 - 269 4M17 B 214 - 249 NGL View in InterPro
H 214 - 249 NGL View in InterPro
4M18 A 214 - 249 NGL View in InterPro
B 214 - 249 NGL View in InterPro
I 214 - 249 NGL View in InterPro
J 214 - 249 NGL View in InterPro
235 - 269 4M17 F 215 - 249 NGL View in InterPro
236 - 269 4M17 A 216 - 249 NGL View in InterPro
D 216 - 249 NGL View in InterPro
E 216 - 249 NGL View in InterPro
G 216 - 249 NGL View in InterPro
I 216 - 249 NGL View in InterPro
J 216 - 249 NGL View in InterPro
237 - 269 4M17 K 217 - 249 NGL View in InterPro
238 - 269 4M17 L 218 - 249 NGL View in InterPro
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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.