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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SCN1A_HUMAN (P35498)

Summary

This is the summary of UniProt entry SCN1A_HUMAN (P35498).

Description: Sodium channel protein type 1 subunit alpha
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 2009 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 4
low_complexity n/a 23 35
disorder n/a 28 53
low_complexity n/a 31 52
transmembrane n/a 124 147
Pfam Ion_trans 127 434
transmembrane n/a 192 211
transmembrane n/a 223 244
transmembrane n/a 250 270
transmembrane n/a 360 379
transmembrane n/a 399 426
coiled_coil n/a 423 468
low_complexity n/a 431 446
disorder n/a 434 439
disorder n/a 445 446
disorder n/a 448 449
low_complexity n/a 449 466
disorder n/a 455 533
low_complexity n/a 479 496
low_complexity n/a 490 519
disorder n/a 542 545
disorder n/a 547 552
Pfam Na_trans_cytopl 555 718
disorder n/a 555 563
disorder n/a 574 578
disorder n/a 585 598
disorder n/a 600 635
disorder n/a 646 647
low_complexity n/a 649 665
disorder n/a 665 667
disorder n/a 669 691
transmembrane n/a 737 755
transmembrane n/a 761 784
Pfam Ion_trans 767 1002
transmembrane n/a 796 817
transmembrane n/a 837 858
low_complexity n/a 855 867
transmembrane n/a 879 907
low_complexity n/a 895 907
transmembrane n/a 937 954
transmembrane n/a 966 992
low_complexity n/a 980 1002
Pfam Na_trans_assoc 1006 1213
low_complexity n/a 1081 1091
disorder n/a 1129 1133
low_complexity n/a 1130 1155
disorder n/a 1135 1174
low_complexity n/a 1162 1178
Pfam Ion_trans 1217 1493
transmembrane n/a 1219 1237
transmembrane n/a 1258 1277
transmembrane n/a 1289 1312
low_complexity n/a 1314 1329
transmembrane n/a 1333 1361
transmembrane n/a 1459 1483
Pfam Ion_trans 1540 1797
transmembrane n/a 1542 1560
transmembrane n/a 1572 1590
transmembrane n/a 1602 1622
transmembrane n/a 1628 1647
low_complexity n/a 1638 1650
transmembrane n/a 1659 1687
disorder n/a 1744 1749
low_complexity n/a 1760 1778
transmembrane n/a 1763 1786
low_complexity n/a 1837 1849
disorder n/a 1904 1907
disorder n/a 1972 1982
disorder n/a 1986 2009

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P35498. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEQTVLVPPG PDSFNFFTRE SLAAIERRIA EEKAKNPKPD KKDDDENGPK
50
51
PNSDLEAGKN LPFIYGDIPP EMVSEPLEDL DPYYINKKTF IVLNKGKAIF
100
101
RFSATSALYI LTPFNPLRKI AIKILVHSLF SMLIMCTILT NCVFMTMSNP
150
151
PDWTKNVEYT FTGIYTFESL IKIIARGFCL EDFTFLRDPW NWLDFTVITF
200
201
AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL IQSVKKLSDV
250
251
MILTVFCLSV FALIGLQLFM GNLRNKCIQW PPTNASLEEH SIEKNITVNY
300
301
NGTLINETVF EFDWKSYIQD SRYHYFLEGF LDALLCGNSS DAGQCPEGYM
350
351
CVKAGRNPNY GYTSFDTFSW AFLSLFRLMT QDFWENLYQL TLRAAGKTYM
400
401
IFFVLVIFLG SFYLINLILA VVAMAYEEQN QATLEEAEQK EAEFQQMIEQ
450
451
LKKQQEAAQQ AATATASEHS REPSAAGRLS DSSSEASKLS SKSAKERRNR
500
501
RKKRKQKEQS GGEEKDEDEF QKSESEDSIR RKGFRFSIEG NRLTYEKRYS
550
551
SPHQSLLSIR GSLFSPRRNS RTSLFSFRGR AKDVGSENDF ADDEHSTFED
600
601
NESRRDSLFV PRRHGERRNS NLSQTSRSSR MLAVFPANGK MHSTVDCNGV
650
651
VSLVGGPSVP TSPVGQLLPE VIIDKPATDD NGTTTETEMR KRRSSSFHVS
700
701
MDFLEDPSQR QRAMSIASIL TNTVEELEES RQKCPPCWYK FSNIFLIWDC
750
751
SPYWLKVKHV VNLVVMDPFV DLAITICIVL NTLFMAMEHY PMTDHFNNVL
800
801
TVGNLVFTGI FTAEMFLKII AMDPYYYFQE GWNIFDGFIV TLSLVELGLA
850
851
NVEGLSVLRS FRLLRVFKLA KSWPTLNMLI KIIGNSVGAL GNLTLVLAII
900
901
VFIFAVVGMQ LFGKSYKDCV CKIASDCQLP RWHMNDFFHS FLIVFRVLCG
950
951
EWIETMWDCM EVAGQAMCLT VFMMVMVIGN LVVLNLFLAL LLSSFSADNL
1000
1001
AATDDDNEMN NLQIAVDRMH KGVAYVKRKI YEFIQQSFIR KQKILDEIKP
1050
1051
LDDLNNKKDS CMSNHTAEIG KDLDYLKDVN GTTSGIGTGS SVEKYIIDES
1100
1101
DYMSFINNPS LTVTVPIAVG ESDFENLNTE DFSSESDLEE SKEKLNESSS
1150
1151
SSEGSTVDIG APVEEQPVVE PEETLEPEAC FTEGCVQRFK CCQINVEEGR
1200
1201
GKQWWNLRRT CFRIVEHNWF ETFIVFMILL SSGALAFEDI YIDQRKTIKT
1250
1251
MLEYADKVFT YIFILEMLLK WVAYGYQTYF TNAWCWLDFL IVDVSLVSLT
1300
1301
ANALGYSELG AIKSLRTLRA LRPLRALSRF EGMRVVVNAL LGAIPSIMNV
1350
1351
LLVCLIFWLI FSIMGVNLFA GKFYHCINTT TGDRFDIEDV NNHTDCLKLI
1400
1401
ERNETARWKN VKVNFDNVGF GYLSLLQVAT FKGWMDIMYA AVDSRNVELQ
1450
1451
PKYEESLYMY LYFVIFIIFG SFFTLNLFIG VIIDNFNQQK KKFGGQDIFM
1500
1501
TEEQKKYYNA MKKLGSKKPQ KPIPRPGNKF QGMVFDFVTR QVFDISIMIL
1550
1551
ICLNMVTMMV ETDDQSEYVT TILSRINLVF IVLFTGECVL KLISLRHYYF
1600
1601
TIGWNIFDFV VVILSIVGMF LAELIEKYFV SPTLFRVIRL ARIGRILRLI
1650
1651
KGAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIYAIFGMS NFAYVKREVG
1700
1701
IDDMFNFETF GNSMICLFQI TTSAGWDGLL APILNSKPPD CDPNKVNPGS
1750
1751
SVKGDCGNPS VGIFFFVSYI IISFLVVVNM YIAVILENFS VATEESAEPL
1800
1801
SEDDFEMFYE VWEKFDPDAT QFMEFEKLSQ FAAALEPPLN LPQPNKLQLI
1850
1851
AMDLPMVSGD RIHCLDILFA FTKRVLGESG EMDALRIQME ERFMASNPSK
1900
1901
VSYQPITTTL KRKQEEVSAV IIQRAYRRHL LKRTVKQASF TYNKNKIKGG
1950
1951
ANLLIKEDMI IDRINENSIT EKTDLTMSTA ACPPSYDRVT KPIVEKHEQE
2000
2001
GKDEKAKGK                                             
2009
 

Show the unformatted sequence.

Checksums:
CRC64:0593A6730F33C9A2
MD5:f85cb3f105a429f003e9cb00398e013a

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.