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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FUS_HUMAN (P35637)

Summary

This is the summary of UniProt entry FUS_HUMAN (P35637).

Description: RNA-binding protein FUS
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 526 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 292
low_complexity n/a 16 50
low_complexity n/a 41 66
low_complexity n/a 66 103
low_complexity n/a 105 157
low_complexity n/a 152 178
low_complexity n/a 176 237
low_complexity n/a 233 260
Pfam RRM_1 287 365
disorder n/a 309 310
disorder n/a 316 330
disorder n/a 332 355
disorder n/a 362 363
disorder n/a 365 432
low_complexity n/a 370 424
Pfam zf-RanBP 422 453
disorder n/a 439 526
low_complexity n/a 449 468
low_complexity n/a 464 506

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P35637. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MASNDYTQQA TQSYGAYPTQ PGQGYSQQSS QPYGQQSYSG YSQSTDTSGY
50
51
GQSSYSSYGQ SQNTGYGTQS TPQGYGSTGG YGSSQSSQSS YGQQSSYPGY
100
101
GQQPAPSSTS GSYGSSSQSS SYGQPQSGSY SQQPSYGGQQ QSYGQQQSYN
150
151
PPQGYGQQNQ YNSSSGGGGG GGGGGNYGQD QSSMSSGGGS GGGYGNQDQS
200
201
GGGGSGGYGQ QDRGGRGRGG SGGGGGGGGG GYNRSSGGYE PRGRGGGRGG
250
251
RGGMGGSDRG GFNKFGGPRD QGSRHDSEQD NSDNNTIFVQ GLGENVTIES
300
301
VADYFKQIGI IKTNKKTGQP MINLYTDRET GKLKGEATVS FDDPPSAKAA
350
351
IDWFDGKEFS GNPIKVSFAT RRADFNRGGG NGRGGRGRGG PMGRGGYGGG
400
401
GSGGGGRGGF PSGGGGGGGQ QRAGDWKCPN PTCENMNFSW RNECNQCKAP
450
451
KPDGPGGGPG GSHMGGNYGD DRRGGRGGYD RGGYRGRGGD RGGFRGGRGG
500
501
GDRGGFGPGK MDSRGEHRQD RRERPY                          
526
 

Show the unformatted sequence.

Checksums:
CRC64:88C8E263B7905549
MD5:81fef7caae3231906fbe85f45e13269b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
RRM_1 287 - 365 2LA6 A 16 - 94 Jmol OpenAstexViewer
2LCW A 287 - 365 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.