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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HNF1B_HUMAN (P35680)

Summary

This is the summary of UniProt entry HNF1B_HUMAN (P35680).

Description: Hepatocyte nuclear factor 1-beta
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 557 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
low_complexity n/a 4 18
Pfam HNF-1_N 8 174
disorder n/a 41 116
low_complexity n/a 74 84
disorder n/a 121 122
disorder n/a 124 128
disorder n/a 132 133
disorder n/a 135 159
disorder n/a 183 194
disorder n/a 215 235
disorder n/a 247 266
disorder n/a 276 282
disorder n/a 284 285
disorder n/a 310 318
Pfam HNF-1B_C 314 550
disorder n/a 320 369
low_complexity n/a 327 343
disorder n/a 371 410
disorder n/a 413 436
disorder n/a 473 475
disorder n/a 477 495
disorder n/a 497 501
disorder n/a 507 529
low_complexity n/a 536 548
disorder n/a 539 540
disorder n/a 544 545

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P35680. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVSKLTSLQQ ELLSALLSSG VTKEVLVQAL EELLPSPNFG VKLETLPLSP
50
51
GSGAEPDTKP VFHTLTNGHA KGRLSGDEGS EDGDDYDTPP ILKELQALNT
100
101
EEAAEQRAEV DRMLSEDPWR AAKMIKGYMQ QHNIPQREVV DVTGLNQSHL
150
151
SQHLNKGTPM KTQKRAALYT WYVRKQREIL RQFNQTVQSS GNMTDKSSQD
200
201
QLLFLFPEFS QQSHGPGQSD DACSEPTNKK MRRNRFKWGP ASQQILYQAY
250
251
DRQKNPSKEE REALVEECNR AECLQRGVSP SKAHGLGSNL VTEVRVYNWF
300
301
ANRRKEEAFR QKLAMDAYSS NQTHSLNPLL SHGSPHHQPS SSPPNKLSGV
350
351
RYSQQGNNEI TSSSTISHHG NSAMVTSQSV LQQVSPASLD PGHNLLSPDG
400
401
KMISVSGGGL PPVSTLTNIH SLSHHNPQQS QNLIMTPLSG VMAIAQSLNT
450
451
SQAQSVPVIN SVAGSLAALQ PVQFSQQLHS PHQQPLMQQS PGSHMAQQPF
500
501
MAAVTQLQNS HMYAHKQEPP QYSHTSRFPS AMVVTDTSSI STLTNMSSSK
550
551
QCPLQAW                                               
557
 

Show the unformatted sequence.

Checksums:
CRC64:9E1ECC7423B73980
MD5:96376ec07d248fed4afb6fa38c6670e7

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
HNF-1_N 91 - 174 2H8R A 91 - 174 Jmol OpenAstexViewer
B 91 - 174 Jmol OpenAstexViewer
HNF-1B_C 314 - 321 2DA6 A 89 - 96 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.