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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PARP_DROME (P35875)

Summary

This is the summary of UniProt entry PARP_DROME (P35875).

Description: Poly [ADP-ribose] polymerase
Source organism: Drosophila melanogaster (Fruit fly) (NCBI taxonomy ID 7227)
Length: 994 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam zf-PARP 10 94
Pfam zf-PARP 114 196
disorder n/a 183 184
disorder n/a 186 187
disorder n/a 194 223
low_complexity n/a 239 255
Pfam PADR1 270 322
Pfam BRCT 380 455
coiled_coil n/a 392 412
disorder n/a 484 485
disorder n/a 487 489
Pfam WGR 536 616
Pfam PARP_reg 645 776
Pfam PARP 790 990

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P35875. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDIELPYLAE YARTGRATCK GCKSTISKDT LRIAVMVQSA FHDAKVPNWF
50
51
HKTCFFKNQR PSSVGDIQNI GNLRFADQKE LTDLVENIQE VISAQLGKKR
100
101
SKAFNLALKD FGIEYAKSSR STCRGCEQKI NKDLVRLRKT VYDTEVGMKY
150
151
GGQPLWHHLE CFAQLRSELG WFASGEDMPG FQSLADDDQA KVKNAIPPIK
200
201
SEELPDTKRA KMELSDTNEE GEKKQRLKDQ NDAYFRFRDD IKNKMKKKDI
250
251
DILLKFNNQQ PVTGDTEKLF DQTADLLTFG AIESCSECNS CQFIVNKSGY
300
301
ICNGNHSEWT KCNKLLKEPT RSACIVPKEL KALYNFLNTV KEIPSTRIFN
350
351
NFPPNKSTFS RSLLKTNKNN DVLVRPTIPR ISPPLYNLKF SIIGLKNQHK
400
401
ELRKRIENLG GKFEVKISEN TIAIISTELE IQKKSTRMKF AEELGIHIVP
450
451
IEFLDFVEAD TEGAIKYINS TCICSWGTDP KSRIPKETTK SLNSNSIYTK
500
501
SMPVSRTFKV KDGLAVDPDS GLEDIAHVYV DSNNKYSVVL GLTDIQRNKN
550
551
SYYKVQLLKA DKKEKYWIFR SWGRIGTNIG NSKLEEFDTS ESAKRNFKEI
600
601
YADKTGNEYE QRDNFVKRTG RMYPIEIQYD DDQKLVKHES HFFTSKLEIS
650
651
VQNLIKLIFD IDSMNKTLME FHIDMDKMPL GKLSAHQIQS AYRVVKEIYN
700
701
VLECGSNTAK LIDATNRFYT LIPHNFGVQL PTLIETHQQI EDLRQMLDSL
750
751
AEIEVAYSII KSEDVSDACN PLDNHYAQIK TQLVALDKNS EEFSILSQYV
800
801
KNTHASTHKS YDLKIVDVFK VSRQGEARRF KPFKKLHNRK LLWHGSRLTN
850
851
FVGILSHGLR IAPPEAPPTG YMFGKGIYFA DMVSKSANYC CTSQQNSTGL
900
901
MLLSEVALGD MMECTSAKYI NKLSNNKHSC FGRGRTMPDP TKSYIRSDGV
950
951
EIPYGETITD EHLKSSLLYN EYIVYDVAQV NIQYLFRMEF KYSY      
994
 

Show the unformatted sequence.

Checksums:
CRC64:ACA85A270DD29E08
MD5:8bab642f038811a69761f3aabb563d48

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;