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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HMGCL_HUMAN (P35914)

Summary

This is the summary of UniProt entry HMGCL_HUMAN (P35914).

Description: Hydroxymethylglutaryl-CoA lyase, mitochondrial
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 325 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 27
Pfam HMGL-like 32 306
low_complexity n/a 111 124

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P35914. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAMRKALPR RLVGLASLRA VSTSSMGTLP KRVKIVEVGP RDGLQNEKNI
50
51
VSTPVKIKLI DMLSEAGLSV IETTSFVSPK WVPQMGDHTE VLKGIQKFPG
100
101
INYPVLTPNL KGFEAAVAAG AKEVVIFGAA SELFTKKNIN CSIEESFQRF
150
151
DAILKAAQSA NISVRGYVSC ALGCPYEGKI SPAKVAEVTK KFYSMGCYEI
200
201
SLGDTIGVGT PGIMKDMLSA VMQEVPLAAL AVHCHDTYGQ ALANTLMALQ
250
251
MGVSVVDSSV AGLGGCPYAQ GASGNLATED LVYMLEGLGI HTGVNLQKLL
300
301
EAGNFICQAL NRKTSSKVAQ ATCKL                           
325
 

Show the unformatted sequence.

Checksums:
CRC64:B82B2488A10D6980
MD5:c67e2ccd812257ea627fed3df6811eec

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
HMGL-like 32 - 306 2CW6 A 32 - 306 Show 3D Structure View in InterPro
B 32 - 306 Show 3D Structure View in InterPro
C 32 - 306 Show 3D Structure View in InterPro
D 32 - 306 Show 3D Structure View in InterPro
E 32 - 306 Show 3D Structure View in InterPro
F 32 - 306 Show 3D Structure View in InterPro
3MP3 A 32 - 306 Show 3D Structure View in InterPro
B 32 - 306 Show 3D Structure View in InterPro
C 32 - 306 Show 3D Structure View in InterPro
D 32 - 306 Show 3D Structure View in InterPro
E 32 - 306 Show 3D Structure View in InterPro
F 32 - 306 Show 3D Structure View in InterPro
3MP4 A 32 - 306 Show 3D Structure View in InterPro
B 32 - 306 Show 3D Structure View in InterPro
C 32 - 306 Show 3D Structure View in InterPro
D 32 - 306 Show 3D Structure View in InterPro
E 32 - 306 Show 3D Structure View in InterPro
F 32 - 306 Show 3D Structure View in InterPro
3MP5 A 32 - 306 Show 3D Structure View in InterPro
B 32 - 306 Show 3D Structure View in InterPro
C 32 - 306 Show 3D Structure View in InterPro
D 32 - 306 Show 3D Structure View in InterPro
E 32 - 306 Show 3D Structure View in InterPro
F 32 - 306 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;