Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
7  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ACHA7_HUMAN (P36544)

Summary

This is the summary of UniProt entry ACHA7_HUMAN (P36544).

Description: Neuronal acetylcholine receptor subunit alpha-7
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 502 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
sig_p n/a 1 22
low_complexity n/a 9 16
Pfam Neur_chan_LBD 26 230
transmembrane n/a 231 255
Pfam Neur_chan_memb 237 487
low_complexity n/a 242 255
transmembrane n/a 262 280
transmembrane n/a 292 317
low_complexity n/a 301 313
disorder n/a 419 425
transmembrane n/a 470 490

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P36544. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRCSPGGVWL ALAASLLHVS LQGEFQRKLY KELVKNYNPL ERPVANDSQP
50
51
LTVYFSLSLL QIMDVDEKNQ VLTTNIWLQM SWTDHYLQWN VSEYPGVKTV
100
101
RFPDGQIWKP DILLYNSADE RFDATFHTNV LVNSSGHCQY LPPGIFKSSC
150
151
YIDVRWFPFD VQHCKLKFGS WSYGGWSLDL QMQEADISGY IPNGEWDLVG
200
201
IPGKRSERFY ECCKEPYPDV TFTVTMRRRT LYYGLNLLIP CVLISALALL
250
251
VFLLPADSGE KISLGITVLL SLTVFMLLVA EIMPATSDSV PLIAQYFAST
300
301
MIIVGLSVVV TVIVLQYHHH DPDGGKMPKW TRVILLNWCA WFLRMKRPGE
350
351
DKVRPACQHK QRRCSLASVE MSAVAPPPAS NGNLLYIGFR GLDGVHCVPT
400
401
PDSGVVCGRM ACSPTHDEHL LHGGQPPEGD PDLAKILEEV RYIANRFRCQ
450
451
DESEAVCSEW KFAACVVDRL CLMAFSVFTI ICTIGILMSA PNFVEAVSKD
500
501
FA                                                    
502
 

Show the unformatted sequence.

Checksums:
CRC64:D94B3A482EAA0E42
MD5:486dcc172254ec9941b4ed1c528e2c9b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Neur_chan_LBD 228 - 230 2MAW A 4 - 6 Jmol OpenAstexViewer
26 - 225 5AFH A 3 - 199 Jmol OpenAstexViewer
B 3 - 199 Jmol OpenAstexViewer
C 3 - 199 Jmol OpenAstexViewer
D 3 - 199 Jmol OpenAstexViewer
E 3 - 199 Jmol OpenAstexViewer
5AFJ A 3 - 199 Jmol OpenAstexViewer
B 3 - 199 Jmol OpenAstexViewer
C 3 - 199 Jmol OpenAstexViewer
D 3 - 199 Jmol OpenAstexViewer
E 3 - 199 Jmol OpenAstexViewer
5AFK A 3 - 199 Jmol OpenAstexViewer
B 3 - 199 Jmol OpenAstexViewer
C 3 - 199 Jmol OpenAstexViewer
D 3 - 199 Jmol OpenAstexViewer
E 3 - 199 Jmol OpenAstexViewer
5AFL A 3 - 199 Jmol OpenAstexViewer
B 3 - 199 Jmol OpenAstexViewer
C 3 - 199 Jmol OpenAstexViewer
D 3 - 199 Jmol OpenAstexViewer
E 3 - 199 Jmol OpenAstexViewer
5AFM A 3 - 199 Jmol OpenAstexViewer
B 3 - 199 Jmol OpenAstexViewer
C 3 - 199 Jmol OpenAstexViewer
D 3 - 199 Jmol OpenAstexViewer
E 3 - 199 Jmol OpenAstexViewer
5AFN A 3 - 199 Jmol OpenAstexViewer
B 3 - 199 Jmol OpenAstexViewer
C 3 - 199 Jmol OpenAstexViewer
D 3 - 199 Jmol OpenAstexViewer
E 3 - 199 Jmol OpenAstexViewer
Neur_chan_memb 237 - 326 2MAW A 13 - 102 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.