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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: LONM_HUMAN (P36776)

Summary

This is the summary of UniProt entry LONM_HUMAN (P36776).

Description: Lon protease homolog, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03120}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 959 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
low_complexity n/a 69 105
disorder n/a 79 103
Pfam LON_substr_bdg 123 368
low_complexity n/a 142 158
disorder n/a 178 181
disorder n/a 218 266
low_complexity n/a 220 229
disorder n/a 270 271
disorder n/a 342 343
low_complexity n/a 360 374
low_complexity n/a 399 410
low_complexity n/a 403 414
Pfam AAA 519 661
Pfam Lon_C 736 949
disorder n/a 784 804
disorder n/a 846 848

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P36776. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAASTGYVRL WGAARCWVLR RPMLAAAGGR VPTAAGAWLL RGQRTCDASP
50
51
PWALWGRGPA IGGQWRGFWE ASSRGGGAFS GGEDASEGGA EEGAGGAGGS
100
101
AGAGEGPVIT ALTPMTIPDV FPHLPLIAIT RNPVFPRFIK IIEVKNKKLV
150
151
ELLRRKVRLA QPYVGVFLKR DDSNESDVVE SLDEIYHTGT FAQIHEMQDL
200
201
GDKLRMIVMG HRRVHISRQL EVEPEEPEAE NKHKPRRKSK RGKKEAEDEL
250
251
SARHPAELAM EPTPELPAEV LMVEVENVVH EDFQVTEEVK ALTAEIVKTI
300
301
RDIIALNPLY RESVLQMMQA GQRVVDNPIY LSDMGAALTG AESHELQDVL
350
351
EETNIPKRLY KALSLLKKEF ELSKLQQRLG REVEEKIKQT HRKYLLQEQL
400
401
KIIKKELGLE KDDKDAIEEK FRERLKELVV PKHVMDVVDE ELSKLGLLDN
450
451
HSSEFNVTRN YLDWLTSIPW GKYSNENLDL ARAQAVLEED HYGMEDVKKR
500
501
ILEFIAVSQL RGSTQGKILC FYGPPGVGKT SIARSIARAL NREYFRFSVG
550
551
GMTDVAEIKG HRRTYVGAMP GKIIQCLKKT KTENPLILID EVDKIGRGYQ
600
601
GDPSSALLEL LDPEQNANFL DHYLDVPVDL SKVLFICTAN VTDTIPEPLR
650
651
DRMEMINVSG YVAQEKLAIA ERYLVPQARA LCGLDESKAK LSSDVLTLLI
700
701
KQYCRESGVR NLQKQVEKVL RKSAYKIVSG EAESVEVTPE NLQDFVGKPV
750
751
FTVERMYDVT PPGVVMGLAW TAMGGSTLFV ETSLRRPQDK DAKGDKDGSL
800
801
EVTGQLGEVM KESARIAYTF ARAFLMQHAP ANDYLVTSHI HLHVPEGATP
850
851
KDGPSAGCTI VTALLSLAMG RPVRQNLAMT GEVSLTGKIL PVGGIKEKTI
900
901
AAKRAGVTCI VLPAENKKDF YDLAAFITEG LEVHFVEHYR EIFDIAFPDE
950
951
QAEALAVER                                             
959
 

Show the unformatted sequence.

Checksums:
CRC64:B5E03D9C27C220FF
MD5:23bbc933c5c6a85b52600d3c16957113

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Lon_C 755 - 949 2X36 C 755 - 949 Jmol OpenAstexViewer
756 - 948 2X36 B 756 - 948 Jmol OpenAstexViewer
756 - 949 2X36 A 756 - 949 Jmol OpenAstexViewer
758 - 948 2X36 E 758 - 948 Jmol OpenAstexViewer
759 - 948 2X36 F 759 - 948 Jmol OpenAstexViewer
760 - 948 2X36 D 760 - 948 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.