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11  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: BMR1A_HUMAN (P36894)

Summary

This is the summary of UniProt entry BMR1A_HUMAN (P36894).

Description: Bone morphogenetic protein receptor type-1A EC=2.7.11.30
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 532 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 23
disorder n/a 29 38
disorder n/a 41 47
Pfam Activin_recp 59 134
transmembrane n/a 153 176
Pfam TGF_beta_GS 205 232
low_complexity n/a 211 220
Pfam PK_Tyr_Ser-Thr 234 521

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P36894. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPQLYIYIRL LGAYLFIISR VQGQNLDSML HGTGMKSDSD QKKSENGVTL
50
51
APEDTLPFLK CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLASGC
100
101
MKYEGSDFQC KDSPKAQLRR TIECCRTNLC NQYLQPTLPP VVIGPFFDGS
150
151
IRWLVLLISM AVCIIAMIIF SSCFCYKHYC KSISSRRRYN RDLEQDEAFI
200
201
PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV GKGRYGEVWM
250
251
GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG
300
301
SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY
350
351
GTQGKPAIAH RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDVPLNT
400
401
RVGTKRYMAP EVLDESLNKN HFQPYIMADI YSFGLIIWEM ARRCITGGIV
450
451
EEYQLPYYNM VPSDPSYEDM REVVCVKRLR PIVSNRWNSD ECLRAVLKLM
500
501
SECWAHNPAS RLTALRIKKT LAKMVESQDV KI                   
532
 

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Checksums:
CRC64:00CE2DDDA3A44170
MD5:2384b8303cf754fa1b560afd8a02eeb3

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Activin_recp 59 - 134 1ES7 B 236 - 311 Jmol OpenAstexViewer
D 736 - 811 Jmol OpenAstexViewer
1REW C 36 - 111 Jmol OpenAstexViewer
D 36 - 111 Jmol OpenAstexViewer
2GOO B 36 - 111 Jmol OpenAstexViewer
E 36 - 111 Jmol OpenAstexViewer
2H62 C 36 - 111 Jmol OpenAstexViewer
2H64 B 36 - 111 Jmol OpenAstexViewer
2K3G A 36 - 111 Jmol OpenAstexViewer
2QJ9 C 36 - 111 Jmol OpenAstexViewer
D 36 - 111 Jmol OpenAstexViewer
2QJA C 36 - 111 Jmol OpenAstexViewer
D 36 - 111 Jmol OpenAstexViewer
2QJB C 36 - 111 Jmol OpenAstexViewer
D 36 - 111 Jmol OpenAstexViewer
3NH7 A 36 - 111 Jmol OpenAstexViewer
B 36 - 111 Jmol OpenAstexViewer
C 36 - 111 Jmol OpenAstexViewer
D 36 - 111 Jmol OpenAstexViewer
3QB4 B 36 - 111 Jmol OpenAstexViewer
D 36 - 111 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.