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38  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TGFR1_HUMAN (P36897)

Summary

This is the summary of UniProt entry TGFR1_HUMAN (P36897).

Description: TGF-beta receptor type-1 EC=2.7.11.30
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 503 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 33
low_complexity n/a 3 34
Pfam Activin_recp 34 110
transmembrane n/a 126 147
Pfam TGF_beta_GS 176 203
Pfam Pkinase 205 492

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P36897. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEAAVAAPRP RLLLLVLAAA AAAAAALLPG ATALQCFCHL CTKDNFTCVT
50
51
DGLCFVSVTE TTDKVIHNSM CIAEIDLIPR DRPFVCAPSS KTGSVTTTYC
100
101
CNQDHCNKIE LPTTVKSSPG LGPVELAAVI AGPVCFVCIS LMLMVYICHN
150
151
RTVIHHRVPN EEDPSLDRPF ISEGTTLKDL IYDMTTSGSG SGLPLLVQRT
200
201
IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER SWFREAEIYQ
250
251
TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE
300
301
GMIKLALSTA SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA
350
351
DLGLAVRHDS ATDTIDIAPN HRVGTKRYMA PEVLDDSINM KHFESFKRAD
400
401
IYAMGLVFWE IARRCSIGGI HEDYQLPYYD LVPSDPSVEE MRKVVCEQKL
450
451
RPNIPNRWQS CEALRVMAKI MRECWYANGA ARLTALRIKK TLSQLSQQEG
500
501
IKM                                                   
503
 

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Checksums:
CRC64:179F11404725DDCB
MD5:2f7226008705915f13913ac61a9faa99

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Activin_recp 34 - 108 3KFD J 10 - 84 NGL View in InterPro
L 10 - 84 NGL View in InterPro
34 - 109 3KFD I 10 - 85 NGL View in InterPro
K 10 - 85 NGL View in InterPro
34 - 110 2L5S A 10 - 86 NGL View in InterPro
2PJY C 10 - 86 NGL View in InterPro
6MAC K 10 - 86 NGL View in InterPro
Pkinase 205 - 492 1B6C B 205 - 492 NGL View in InterPro
D 205 - 492 NGL View in InterPro
F 205 - 492 NGL View in InterPro
H 205 - 492 NGL View in InterPro
1IAS A 205 - 492 NGL View in InterPro
B 205 - 492 NGL View in InterPro
C 205 - 492 NGL View in InterPro
D 205 - 492 NGL View in InterPro
E 205 - 492 NGL View in InterPro
1PY5 A 205 - 492 NGL View in InterPro
1RW8 A 205 - 492 NGL View in InterPro
1VJY A 205 - 492 NGL View in InterPro
2WOT A 205 - 492 NGL View in InterPro
2WOU A 205 - 492 NGL View in InterPro
2X7O A 205 - 492 NGL View in InterPro
B 205 - 492 NGL View in InterPro
C 205 - 492 NGL View in InterPro
D 205 - 492 NGL View in InterPro
E 205 - 492 NGL View in InterPro
3FAA A 205 - 492 NGL View in InterPro
B 205 - 492 NGL View in InterPro
C 205 - 492 NGL View in InterPro
D 205 - 492 NGL View in InterPro
E 205 - 492 NGL View in InterPro
3GXL A 5 - 292 NGL View in InterPro
3HMM A 5 - 292 NGL View in InterPro
3KCF A 205 - 492 NGL View in InterPro
B 205 - 492 NGL View in InterPro
C 205 - 492 NGL View in InterPro
D 205 - 492 NGL View in InterPro
E 205 - 492 NGL View in InterPro
3TZM A 205 - 492 NGL View in InterPro
4X0M A 205 - 492 NGL View in InterPro
4X2F A 205 - 492 NGL View in InterPro
4X2G A 205 - 492 NGL View in InterPro
4X2J A 205 - 492 NGL View in InterPro
4X2K A 205 - 492 NGL View in InterPro
4X2N A 205 - 492 NGL View in InterPro
5E8S A 205 - 492 NGL View in InterPro
5E8T A 205 - 492 NGL View in InterPro
5E8U A 205 - 492 NGL View in InterPro
5E8W A 205 - 492 NGL View in InterPro
5E8X A 205 - 492 NGL View in InterPro
5E8Z A 205 - 492 NGL View in InterPro
5E90 A 205 - 492 NGL View in InterPro
5FRI A 205 - 492 NGL View in InterPro
5QIK A 205 - 492 NGL View in InterPro
5QIL A 205 - 492 NGL View in InterPro
5QIM A 205 - 492 NGL View in InterPro
5QTZ A 205 - 492 NGL View in InterPro
5QU0 A 205 - 492 NGL View in InterPro
5USQ A 205 - 492 NGL View in InterPro
6B8Y A 205 - 492 NGL View in InterPro
TGF_beta_GS 176 - 203 1B6C B 176 - 203 NGL View in InterPro
D 176 - 203 NGL View in InterPro
F 176 - 203 NGL View in InterPro
H 176 - 203 NGL View in InterPro
1IAS A 176 - 203 NGL View in InterPro
B 176 - 203 NGL View in InterPro
C 176 - 203 NGL View in InterPro
D 176 - 203 NGL View in InterPro
E 176 - 203 NGL View in InterPro
2X7O A 176 - 203 NGL View in InterPro
B 176 - 203 NGL View in InterPro
C 176 - 203 NGL View in InterPro
D 176 - 203 NGL View in InterPro
E 176 - 203 NGL View in InterPro
3FAA A 176 - 203 NGL View in InterPro
B 176 - 203 NGL View in InterPro
C 176 - 203 NGL View in InterPro
D 176 - 203 NGL View in InterPro
E 176 - 203 NGL View in InterPro
3KCF A 176 - 203 NGL View in InterPro
B 176 - 203 NGL View in InterPro
C 176 - 203 NGL View in InterPro
D 176 - 203 NGL View in InterPro
E 176 - 203 NGL View in InterPro
200 - 203 1PY5 A 200 - 203 NGL View in InterPro
1RW8 A 200 - 203 NGL View in InterPro
2WOT A 200 - 203 NGL View in InterPro
2WOU A 200 - 203 NGL View in InterPro
3TZM A 200 - 203 NGL View in InterPro
4X0M A 200 - 203 NGL View in InterPro
4X2F A 200 - 203 NGL View in InterPro
4X2G A 200 - 203 NGL View in InterPro
4X2J A 200 - 203 NGL View in InterPro
4X2K A 200 - 203 NGL View in InterPro
4X2N A 200 - 203 NGL View in InterPro
5E8S A 200 - 203 NGL View in InterPro
5E8T A 200 - 203 NGL View in InterPro
5E8U A 200 - 203 NGL View in InterPro
5E8W A 200 - 203 NGL View in InterPro
5E8X A 200 - 203 NGL View in InterPro
5E8Z A 200 - 203 NGL View in InterPro
5E90 A 200 - 203 NGL View in InterPro
5FRI A 200 - 203 NGL View in InterPro
5QIK A 200 - 203 NGL View in InterPro
5QIL A 200 - 203 NGL View in InterPro
5QIM A 200 - 203 NGL View in InterPro
5QTZ A 200 - 203 NGL View in InterPro
5QU0 A 200 - 203 NGL View in InterPro
5USQ A 200 - 203 NGL View in InterPro
6B8Y A 200 - 203 NGL View in InterPro
201 - 203 1VJY A 201 - 203 NGL View in InterPro
3GXL A 1 - 3 NGL View in InterPro
3HMM A 1 - 3 NGL View in InterPro
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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.