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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SPB5_HUMAN (P36952)

Summary

This is the summary of UniProt entry SPB5_HUMAN (P36952).

Description: Serpin B5
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 375 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Serpin 6 375
disorder n/a 186 190
disorder n/a 242 243

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P36952. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDALQLANSA FAVDLFKQLC EKEPLGNVLF SPICLSTSLS LAQVGAKGDT
50
51
ANEIGQVLHF ENVKDVPFGF QTVTSDVNKL SSFYSLKLIK RLYVDKSLNL
100
101
STEFISSTKR PYAKELETVD FKDKLEETKG QINNSIKDLT DGHFENILAD
150
151
NSVNDQTKIL VVNAAYFVGK WMKKFSESET KECPFRVNKT DTKPVQMMNM
200
201
EATFCMGNID SINCKIIELP FQNKHLSMFI LLPKDVEDES TGLEKIEKQL
250
251
NSESLSQWTN PSTMANAKVK LSIPKFKVEK MIDPKACLEN LGLKHIFSED
300
301
TSDFSGMSET KGVALSNVIH KVCLEITEDG GDSIEVPGAR ILQHKDELNA
350
351
DHPFIYIIRH NKTRNIIFFG KFCSP                           
375
 

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Checksums:
CRC64:9F24E18505912804
MD5:07d06fd58d1eab7dd89b019edd40cc71

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Serpin 6 - 375 1WZ9 A 6 - 375 Jmol OpenAstexViewer
B 6 - 375 Jmol OpenAstexViewer
1XQG A 6 - 375 Jmol OpenAstexViewer
B 6 - 375 Jmol OpenAstexViewer
1XQJ A 6 - 375 Jmol OpenAstexViewer
1XU8 A 6 - 375 Jmol OpenAstexViewer
B 6 - 375 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.